目的:观察特定电磁波灸疗贴联合康复训练治疗腰椎间盘突出症的临床疗效。方法:将120例患者随机分为两组,每组60例。两组均行特定电磁波灸疗贴治疗,观察组同时给予康复训练治疗,观察两组临床疗效及治疗前后疼痛视觉模拟评分(visual analo...目的:观察特定电磁波灸疗贴联合康复训练治疗腰椎间盘突出症的临床疗效。方法:将120例患者随机分为两组,每组60例。两组均行特定电磁波灸疗贴治疗,观察组同时给予康复训练治疗,观察两组临床疗效及治疗前后疼痛视觉模拟评分(visual analog scale,VAS)、Oswestry残疾指数(the Oswestry disability index,ODI)评分、日本骨科协会评估治疗(Japanese orthopaedic association scores,JOA)评分的变化情况。结果:总有效率观察组为93.3%(56/60),对照组为78.3%(47/60),两组比较差异有统计学意义(P<0.05)。VAS评分两组治疗前比较,差异无统计学意义(P>0.05);治疗后相同时间点两组比较,差异有统计学意义(P<0.05)。腰椎活动度及ODI、JOA评分治疗前两组比较,差异无统计学意义(P>0.05);治疗前后两组组内比较,差异有统计学意义(P<0.05);治疗后两组组间比较,差异有统计学意义(P<0.05)。结论:特定电磁波灸疗联合康复训练治疗腰椎间盘突出症有助于提高患者临床疗效,减轻临床症状,改善腰椎功能。展开更多
Objective To observe the changes in hepatic histomorphology and the differences in the expression of PD-1 after different moxibustion interventions in the immunosuppressed rabbits caused by cyclophosphamide and analyz...Objective To observe the changes in hepatic histomorphology and the differences in the expression of PD-1 after different moxibustion interventions in the immunosuppressed rabbits caused by cyclophosphamide and analyze the intervention effects of different moxibustion therapies.Methods A total of 40 big-ear white rabbits were randomized into 4 groups,i.e.a blank group,an immunosuppressed model group,a moxibustion group and a herbal-paste isolated moxibustion group,10 rabbits in each one.In the immunosuppressed model group,the moxibustion group and the herbal-paste isolated moxibustion group,the intraperitoneal injection with cyclophosphamide was administered consecutively for 7 days,60 mg/kg,and then,the immunosuppressed models were prepared.After the models were established successfully,in the moxibustion group and the herbal-paste isolated moxibustion group,moxibustion was administer at"Shénquè(神阙CV 8)""Guānyuán(关元CV 4)""Zúsānlĭ(足三里ST 36)""Píshū(脾俞BL20)"and"Shènshū(肾俞BL23)",once every other day,10 times in total.In the blank group and the immunosuppressed model group,the rabbits were restricted on the rabbit platform at the same time periods,without intervention.On the second day after the end of intervention,the animals were weighed and anesthetized,and the livers were extracted.After routine HE staining,the changes of hepatic histomorphology were observed under the microscope and the morphometric analysis was conducted in each group.Besides,PD-1 expression was observed with immunohistochemical method.Result Compared with the blank group,after modeling of each animal in three groups,the body mass decreased obviously(all P<0.01),the hepatocyte count decreased(all P<0.01),the inflammatory cellular infiltration area was increased obviously(all P<0.01),necrosis appeared in hepatic tissue and the positive expression of PD-1 in hepatic tissue was significantly increased(all P<0.01).After moxibustion intervention,compared with the immunosuppressed model group,the body masses of the an展开更多
文摘目的:观察特定电磁波灸疗贴联合康复训练治疗腰椎间盘突出症的临床疗效。方法:将120例患者随机分为两组,每组60例。两组均行特定电磁波灸疗贴治疗,观察组同时给予康复训练治疗,观察两组临床疗效及治疗前后疼痛视觉模拟评分(visual analog scale,VAS)、Oswestry残疾指数(the Oswestry disability index,ODI)评分、日本骨科协会评估治疗(Japanese orthopaedic association scores,JOA)评分的变化情况。结果:总有效率观察组为93.3%(56/60),对照组为78.3%(47/60),两组比较差异有统计学意义(P<0.05)。VAS评分两组治疗前比较,差异无统计学意义(P>0.05);治疗后相同时间点两组比较,差异有统计学意义(P<0.05)。腰椎活动度及ODI、JOA评分治疗前两组比较,差异无统计学意义(P>0.05);治疗前后两组组内比较,差异有统计学意义(P<0.05);治疗后两组组间比较,差异有统计学意义(P<0.05)。结论:特定电磁波灸疗联合康复训练治疗腰椎间盘突出症有助于提高患者临床疗效,减轻临床症状,改善腰椎功能。
基金Supported by National Natural Science Foundation of China:81674062。
文摘Objective To observe the changes in hepatic histomorphology and the differences in the expression of PD-1 after different moxibustion interventions in the immunosuppressed rabbits caused by cyclophosphamide and analyze the intervention effects of different moxibustion therapies.Methods A total of 40 big-ear white rabbits were randomized into 4 groups,i.e.a blank group,an immunosuppressed model group,a moxibustion group and a herbal-paste isolated moxibustion group,10 rabbits in each one.In the immunosuppressed model group,the moxibustion group and the herbal-paste isolated moxibustion group,the intraperitoneal injection with cyclophosphamide was administered consecutively for 7 days,60 mg/kg,and then,the immunosuppressed models were prepared.After the models were established successfully,in the moxibustion group and the herbal-paste isolated moxibustion group,moxibustion was administer at"Shénquè(神阙CV 8)""Guānyuán(关元CV 4)""Zúsānlĭ(足三里ST 36)""Píshū(脾俞BL20)"and"Shènshū(肾俞BL23)",once every other day,10 times in total.In the blank group and the immunosuppressed model group,the rabbits were restricted on the rabbit platform at the same time periods,without intervention.On the second day after the end of intervention,the animals were weighed and anesthetized,and the livers were extracted.After routine HE staining,the changes of hepatic histomorphology were observed under the microscope and the morphometric analysis was conducted in each group.Besides,PD-1 expression was observed with immunohistochemical method.Result Compared with the blank group,after modeling of each animal in three groups,the body mass decreased obviously(all P<0.01),the hepatocyte count decreased(all P<0.01),the inflammatory cellular infiltration area was increased obviously(all P<0.01),necrosis appeared in hepatic tissue and the positive expression of PD-1 in hepatic tissue was significantly increased(all P<0.01).After moxibustion intervention,compared with the immunosuppressed model group,the body masses of the an
