In order to understand the role of Le+Y oligosaccharide antigen (Le+Y) during implantation, the relationship of Le+Y on the cell surface with matrix metalloproteinase (MMPs) secreted by blastocysts and monolayer epith...In order to understand the role of Le+Y oligosaccharide antigen (Le+Y) during implantation, the relationship of Le+Y on the cell surface with matrix metalloproteinase (MMPs) secreted by blastocysts and monolayer epithelial cells during implantation in the mouse %in vitro% was studied by monoclonal antibody (mAb) AH-6, directed to Le+Y[Fuc α1-2 Gal β1-4 (Fuc α1-3) GlcNAc-], and gelatin zymography. The results showed that MMPs secretion was reduced after Le+Y on the cell surface of either epithelial cells or trophoblasts was blocked. It indicated that MMPs expression which played an important function during the process of implantation were regulated by Le+Y. Therefore, it was considered that Le+Y could regulate embryos invasion by some mechanism.展开更多
Asphalt mow strips are typically used as vegetation barriers around guardrail posts in the design of roadside safety structures. Asphalt mow strips have historically been modeled as a rigid layer in simulations;this a...Asphalt mow strips are typically used as vegetation barriers around guardrail posts in the design of roadside safety structures. Asphalt mow strips have historically been modeled as a rigid layer in simulations;this assumption results in significant ground level restraint on the guardrail post. However, experiments have shown that asphalt rupture should be considered in the analysis of the response of guardrail posts embedded in mow strips. The present study investigates the effect of asphalt material properties and mow strip geometry on guardrail post performance using finite element simulations. Numerical simulations are performed and correlated with results from static experiments and material testing. The test simulations and experimental results are used to evaluate the response of guardrail posts with various mow strip designs to predict the level of restraint from the asphalt layer. The model is then used to investigate the effects of asphalt material properties and mow strip geometry on the overall performance of the system. The results demonstrate that including asphalt rupture in numerical simulations is essential in accurately predicting the behavior of guardrail posts installed in asphalt mow strips. In addition, mow strip geometry along with asphalt material properties significantly affect the guardrail post response.展开更多
文摘In order to understand the role of Le+Y oligosaccharide antigen (Le+Y) during implantation, the relationship of Le+Y on the cell surface with matrix metalloproteinase (MMPs) secreted by blastocysts and monolayer epithelial cells during implantation in the mouse %in vitro% was studied by monoclonal antibody (mAb) AH-6, directed to Le+Y[Fuc α1-2 Gal β1-4 (Fuc α1-3) GlcNAc-], and gelatin zymography. The results showed that MMPs secretion was reduced after Le+Y on the cell surface of either epithelial cells or trophoblasts was blocked. It indicated that MMPs expression which played an important function during the process of implantation were regulated by Le+Y. Therefore, it was considered that Le+Y could regulate embryos invasion by some mechanism.
文摘Asphalt mow strips are typically used as vegetation barriers around guardrail posts in the design of roadside safety structures. Asphalt mow strips have historically been modeled as a rigid layer in simulations;this assumption results in significant ground level restraint on the guardrail post. However, experiments have shown that asphalt rupture should be considered in the analysis of the response of guardrail posts embedded in mow strips. The present study investigates the effect of asphalt material properties and mow strip geometry on guardrail post performance using finite element simulations. Numerical simulations are performed and correlated with results from static experiments and material testing. The test simulations and experimental results are used to evaluate the response of guardrail posts with various mow strip designs to predict the level of restraint from the asphalt layer. The model is then used to investigate the effects of asphalt material properties and mow strip geometry on the overall performance of the system. The results demonstrate that including asphalt rupture in numerical simulations is essential in accurately predicting the behavior of guardrail posts installed in asphalt mow strips. In addition, mow strip geometry along with asphalt material properties significantly affect the guardrail post response.
