Background Abdominal pain is a common symptom among patients with acute appendicitis, yet these patients have long been denied relief from suffering because of widespread misconceptions associated with the use of opio...Background Abdominal pain is a common symptom among patients with acute appendicitis, yet these patients have long been denied relief from suffering because of widespread misconceptions associated with the use of opioids. We determined whether morphine hydrochloride masked the physical signs in adults with acute appendicitis and assessed the efficacy of morphine in relieving abdominal pain. Methods A prospective, double-blind, placebo controlled, clinical trial was conducted with 106 adult patients between 16 and 70 years old with acute appendicitis. Patients were randomly divided into a morphine group （n=-54） or a normal saline group （n=52）. All patients presented with acute abdominal pain with onset within 3 days. The morphine group received hypodermic injection of morphine （0.15 mg/kg; maximum 20 mg） and the control group members were given an equivalent volume of normal saline solution. The clinical symptoms, physical signs, and patients＇ cooperation during physical examination were assessed before and after 30 minutes of morphine or normal saline administration. Results Abdominal pain was significantly relieved and the patients＇ cooperation was improved in the morphine group after 30 minutes treatment compared with the control group and before morphine administration （P 〈0.05）. The physical signs were unaffected by either treatment （P 〉0.05）. Conclusions Morphine relieved abdominal pain and improved the patients＇ cooperation for treatment and care. Furthermore, the morphine did not mask the physical signs of acute appendicitis.展开更多
目的评价盐酸氢吗啡酮与盐酸吗啡应用于前列腺电切术后硬膜外镇痛的效果及其对Ramsay评分、VAS评分的影响。方法研究时段:2017年5月-2018年6月,研究对象:研究时段内本院收治的62例行前列腺电切术的患者,以入院时间的单双数为分组原则,...目的评价盐酸氢吗啡酮与盐酸吗啡应用于前列腺电切术后硬膜外镇痛的效果及其对Ramsay评分、VAS评分的影响。方法研究时段:2017年5月-2018年6月,研究对象:研究时段内本院收治的62例行前列腺电切术的患者,以入院时间的单双数为分组原则,将研究对象分为对照组、实验组,每组病例均31例。对照组用盐酸吗啡麻醉,实验组用盐酸氢吗啡酮麻醉,对比两组Ramsay评分、VAS评分及不良反应发生概率。结果术后2 h至术后4 hVAS评分对比,实验组低于对照组(P<0.05);术后、术后6 h至24 h VAS评分对比,两组不具有统计学意义(P>0.05)。术后2 h至术后4 h Ramsay评分对比,实验组高于对照组(P<0.05);术后、术后6 h至24 h Ramsay评分对比,两组不具有统计学意义(P>0.05)。不良反应发生概率对比,实验组与对照组不具有明显差异(P>0.05)。结论在前列腺电切术后硬膜外镇痛中,盐酸氢吗啡酮与盐酸吗啡均具有一定的效果,但前者在术后(2～6)h内疼痛程度、镇痛效果均优于后者,临床认可度较高,值得临床推广采用。展开更多
文摘Background Abdominal pain is a common symptom among patients with acute appendicitis, yet these patients have long been denied relief from suffering because of widespread misconceptions associated with the use of opioids. We determined whether morphine hydrochloride masked the physical signs in adults with acute appendicitis and assessed the efficacy of morphine in relieving abdominal pain. Methods A prospective, double-blind, placebo controlled, clinical trial was conducted with 106 adult patients between 16 and 70 years old with acute appendicitis. Patients were randomly divided into a morphine group （n=-54） or a normal saline group （n=52）. All patients presented with acute abdominal pain with onset within 3 days. The morphine group received hypodermic injection of morphine （0.15 mg/kg; maximum 20 mg） and the control group members were given an equivalent volume of normal saline solution. The clinical symptoms, physical signs, and patients＇ cooperation during physical examination were assessed before and after 30 minutes of morphine or normal saline administration. Results Abdominal pain was significantly relieved and the patients＇ cooperation was improved in the morphine group after 30 minutes treatment compared with the control group and before morphine administration （P 〈0.05）. The physical signs were unaffected by either treatment （P 〉0.05）. Conclusions Morphine relieved abdominal pain and improved the patients＇ cooperation for treatment and care. Furthermore, the morphine did not mask the physical signs of acute appendicitis.
文摘目的评价盐酸氢吗啡酮与盐酸吗啡应用于前列腺电切术后硬膜外镇痛的效果及其对Ramsay评分、VAS评分的影响。方法研究时段:2017年5月-2018年6月,研究对象:研究时段内本院收治的62例行前列腺电切术的患者,以入院时间的单双数为分组原则,将研究对象分为对照组、实验组,每组病例均31例。对照组用盐酸吗啡麻醉,实验组用盐酸氢吗啡酮麻醉,对比两组Ramsay评分、VAS评分及不良反应发生概率。结果术后2 h至术后4 hVAS评分对比,实验组低于对照组(P<0.05);术后、术后6 h至24 h VAS评分对比,两组不具有统计学意义(P>0.05)。术后2 h至术后4 h Ramsay评分对比,实验组高于对照组(P<0.05);术后、术后6 h至24 h Ramsay评分对比,两组不具有统计学意义(P>0.05)。不良反应发生概率对比,实验组与对照组不具有明显差异(P>0.05)。结论在前列腺电切术后硬膜外镇痛中,盐酸氢吗啡酮与盐酸吗啡均具有一定的效果,但前者在术后(2～6)h内疼痛程度、镇痛效果均优于后者,临床认可度较高,值得临床推广采用。
