多功能含能结构材料是化学能和动能综合利用的用于提高战斗部毁伤效能的新型功能材料。本研究着重介绍了多功能含能结构材料及其应用的国内外研究现状。对多功能含能结构材料作用特性的实验测试方法、作用机理和理论模型进行了简要的评...多功能含能结构材料是化学能和动能综合利用的用于提高战斗部毁伤效能的新型功能材料。本研究着重介绍了多功能含能结构材料及其应用的国内外研究现状。对多功能含能结构材料作用特性的实验测试方法、作用机理和理论模型进行了简要的评述;阐述了冲击诱发化学反应(shock induced chemical reactions,SICR)方法理论基础和数值仿真方法,并对多功能含能材料的应用现状和前景进行了展望,并给出了近期开展工作的建议。展开更多
The recent pandemic of coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 has raised global health concerns.The viral 3-chymotrypsin-like cysteine protease(3CL^pro)enzyme controls coronavirus replication and is es...The recent pandemic of coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 has raised global health concerns.The viral 3-chymotrypsin-like cysteine protease(3CL^pro)enzyme controls coronavirus replication and is essential for its life cycle.3CL^pro is a proven drug discovery target in the case of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV).Recent studies revealed that the genome sequence of SARS-CoV-2 is very similar to that of SARS-CoV.Therefore,herein,we analysed the 3CL^pro sequence,constructed its 3D homology model,and screened it against a medicinal plant library containing 32,297 potential anti-viral phytochemicals/traditional Chinese medicinal compounds.Our analyses revealed that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules for further optimisation and drug development process to combat COVID-19.展开更多
文摘多功能含能结构材料是化学能和动能综合利用的用于提高战斗部毁伤效能的新型功能材料。本研究着重介绍了多功能含能结构材料及其应用的国内外研究现状。对多功能含能结构材料作用特性的实验测试方法、作用机理和理论模型进行了简要的评述;阐述了冲击诱发化学反应(shock induced chemical reactions,SICR)方法理论基础和数值仿真方法,并对多功能含能材料的应用现状和前景进行了展望,并给出了近期开展工作的建议。
基金This work was supported by the National Key Research and Development Program of China(2020YFC0845600)the Hubei Provincial Natural Science Foundation of China(2019CFA014)+1 种基金the Starting Research Grant for High-level Talents from Guangxi University,Nanning,ChinaPostdoctoral Research Platform Grant of Guangxi University,Nanning,China.
文摘The recent pandemic of coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 has raised global health concerns.The viral 3-chymotrypsin-like cysteine protease(3CL^pro)enzyme controls coronavirus replication and is essential for its life cycle.3CL^pro is a proven drug discovery target in the case of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV).Recent studies revealed that the genome sequence of SARS-CoV-2 is very similar to that of SARS-CoV.Therefore,herein,we analysed the 3CL^pro sequence,constructed its 3D homology model,and screened it against a medicinal plant library containing 32,297 potential anti-viral phytochemicals/traditional Chinese medicinal compounds.Our analyses revealed that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules for further optimisation and drug development process to combat COVID-19.
