The completion of genome sequences and subsequent high-throughput mapping of molecular networks have allowed us to study biology from the network perspective. Experimental, statistical and mathematical modeling approa...The completion of genome sequences and subsequent high-throughput mapping of molecular networks have allowed us to study biology from the network perspective. Experimental, statistical and mathematical modeling approaches have been employed to study the structure, function and dynamics of molecular networks, and begin to reveal important links of various network properties to the functions of the biological systems. In agreement with these functional links, evolutionary selection of a network is apparently based on the function, rather than directly on the structure of the network. Dynamic modularity is one of the prominent features of molecular networks. Taking advantage of such a feature may simplify network-based biological studies through construction of process-specific modular networks and provide functional and mechanistic insights linking genotypic variations to complex traits or diseases, which is likely to be a key approach in the next wave of understanding complex human diseases. With the development of ready-to-use network analysis and modeling tools the networks approaches will be infused into everyday biological research in the near future.展开更多
We ascertain the modularity-like objective function whose optimization is equivalent to the maximum likelihood in annotated networks. We demonstrate that the modularity-like objective function is a lin- ear combinatio...We ascertain the modularity-like objective function whose optimization is equivalent to the maximum likelihood in annotated networks. We demonstrate that the modularity-like objective function is a lin- ear combination of modularity and conditional entropy. In contrast with statistical inference methods, in our method, the influence of the metadata is adjustable; when its influence is strong enough, the metadata can be recovered. Conversely, when it is weak, the detection may correspond to another partition. Between the two, there is a transition. This paper provides a concept for expanding the scope of modularity methods.展开更多
Mass customization(MC)cabinet furniture has rapidly developed into the mainstream mode of furniture manufacturing in the information age with cus-tomized products and services,mass production mode and complete and uni...Mass customization(MC)cabinet furniture has rapidly developed into the mainstream mode of furniture manufacturing in the information age with cus-tomized products and services,mass production mode and complete and unified space joint form through the design system of“standard unit cabinet+nonstan-dardized customized cabinet”.Based on this,taking the design of a standard unit cabinet as the center,the modular design method is used to study the design of functional modules in a standard unit cabinet based on a CAD drawing form.In this paper,the relationship between the function and structure of a standard unit cabinet is analysed according to the principles of serialization,generaliza-tion and combination in the standardized design principles of a custom wardrobe,combined with the modular design method.Finally,the functional and structural design of two standardized series of wardrobes from the Korean furniture brand“Hanssen”is studied in terms of functional and structural dimensions.Conclusion:MC wardrobe can be designed using a combination of configurations of functional modules to achieve a standardized design that reduces the internal diversity of the product and increases the external diversity of the product.In addition,functional modules and structural design have an adaptive relationship in the design of a standard unit cabinet for a custom wardrobe.It is hoped that this study can have some reference value for the practice of MC furniture and the development of functional modules for custom wardrobes.展开更多
文摘The completion of genome sequences and subsequent high-throughput mapping of molecular networks have allowed us to study biology from the network perspective. Experimental, statistical and mathematical modeling approaches have been employed to study the structure, function and dynamics of molecular networks, and begin to reveal important links of various network properties to the functions of the biological systems. In agreement with these functional links, evolutionary selection of a network is apparently based on the function, rather than directly on the structure of the network. Dynamic modularity is one of the prominent features of molecular networks. Taking advantage of such a feature may simplify network-based biological studies through construction of process-specific modular networks and provide functional and mechanistic insights linking genotypic variations to complex traits or diseases, which is likely to be a key approach in the next wave of understanding complex human diseases. With the development of ready-to-use network analysis and modeling tools the networks approaches will be infused into everyday biological research in the near future.
基金This work was funded by the National Natural Science Foundation of China （Grant Nos. 11275186, 91024026, and FOM2014OF001）.
文摘We ascertain the modularity-like objective function whose optimization is equivalent to the maximum likelihood in annotated networks. We demonstrate that the modularity-like objective function is a lin- ear combination of modularity and conditional entropy. In contrast with statistical inference methods, in our method, the influence of the metadata is adjustable; when its influence is strong enough, the metadata can be recovered. Conversely, when it is weak, the detection may correspond to another partition. Between the two, there is a transition. This paper provides a concept for expanding the scope of modularity methods.
文摘Mass customization(MC)cabinet furniture has rapidly developed into the mainstream mode of furniture manufacturing in the information age with cus-tomized products and services,mass production mode and complete and unified space joint form through the design system of“standard unit cabinet+nonstan-dardized customized cabinet”.Based on this,taking the design of a standard unit cabinet as the center,the modular design method is used to study the design of functional modules in a standard unit cabinet based on a CAD drawing form.In this paper,the relationship between the function and structure of a standard unit cabinet is analysed according to the principles of serialization,generaliza-tion and combination in the standardized design principles of a custom wardrobe,combined with the modular design method.Finally,the functional and structural design of two standardized series of wardrobes from the Korean furniture brand“Hanssen”is studied in terms of functional and structural dimensions.Conclusion:MC wardrobe can be designed using a combination of configurations of functional modules to achieve a standardized design that reduces the internal diversity of the product and increases the external diversity of the product.In addition,functional modules and structural design have an adaptive relationship in the design of a standard unit cabinet for a custom wardrobe.It is hoped that this study can have some reference value for the practice of MC furniture and the development of functional modules for custom wardrobes.
