Objective To investigate the changes of cerebral oxygen supply and demand during coronary artery bypass grafting (CABG) with the mild hypothermic cardiopulmonary bypass (CPB).Methods: Adult(n=17) free of diabetes mell...Objective To investigate the changes of cerebral oxygen supply and demand during coronary artery bypass grafting (CABG) with the mild hypothermic cardiopulmonary bypass (CPB).Methods: Adult(n=17) free of diabetes mellitas, cerebral vascular diseases undergoing coronary artery bypass grafting(CABG) were selected. Jugular bulb oxygen saturation (SjO2),arterial-venous oxygen content difference (Da-VO2),and arterial-venous lactate difference (Da-VL),oxygen extract rate(O2ER)were measured at various times: before CPB, during cooling at nasopharyngeal temperature (NPT) 33℃,during stable hypothermia, during rewarming at NPT 37℃, and 20 minutes after CPB as well as the end of operation.Result: During rewarming, SjO2 decreased and O2ER increased significantly compared with that of pre-CPB that of stage. but Da-vL and GER did not change significantly during anesthesia in all patients. SjO2 was negatively correlated to NPT(r=-0.6423,P<0.05). Conclusion: Rewarming period is still critical for O2 desaturation of the brain. The changes of body tempera ture is an important factor affecting cerebral oxygen balance, but the critical level of SjO2 as an predictor of neurologic injure in mild hypothermic CPB is not known.展开更多
文摘Objective To investigate the changes of cerebral oxygen supply and demand during coronary artery bypass grafting (CABG) with the mild hypothermic cardiopulmonary bypass (CPB).Methods: Adult(n=17) free of diabetes mellitas, cerebral vascular diseases undergoing coronary artery bypass grafting(CABG) were selected. Jugular bulb oxygen saturation (SjO2),arterial-venous oxygen content difference (Da-VO2),and arterial-venous lactate difference (Da-VL),oxygen extract rate(O2ER)were measured at various times: before CPB, during cooling at nasopharyngeal temperature (NPT) 33℃,during stable hypothermia, during rewarming at NPT 37℃, and 20 minutes after CPB as well as the end of operation.Result: During rewarming, SjO2 decreased and O2ER increased significantly compared with that of pre-CPB that of stage. but Da-vL and GER did not change significantly during anesthesia in all patients. SjO2 was negatively correlated to NPT(r=-0.6423,P<0.05). Conclusion: Rewarming period is still critical for O2 desaturation of the brain. The changes of body tempera ture is an important factor affecting cerebral oxygen balance, but the critical level of SjO2 as an predictor of neurologic injure in mild hypothermic CPB is not known.
