The Mesozoic–Cenozoic tectonic movement largely controls the northwest region of the Junggar Basin（NWJB）, which is a significant area for the exploration of petroleum and sandstone-type uranium deposits in China. T...The Mesozoic–Cenozoic tectonic movement largely controls the northwest region of the Junggar Basin（NWJB）, which is a significant area for the exploration of petroleum and sandstone-type uranium deposits in China. This work collected six samples from this sedimentary basin and surrounding mountains to conduct apatite fission track（AFT） dating, and utilized the dating results for thermochronological modeling to reconstruct the uplift history of the NWJB and its response to hydrocarbon migration and uranium mineralization. The results indicate that a single continuous uplift event has occurred since the Early Cretaceous, showing spatiotemporal variation in the uplift and exhumation patterns throughout the NWJB. Uplift and exhumation initiated in the northwest and then proceeded to the southeast, suggesting that the fault system induced a post spread-thrust nappe into the basin during the Late Yanshanian. Modeling results indicate that the NWJB mountains have undergone three distinct stages of rapid cooling： Early Cretaceous（ca. 140–115 Ma）, Late Cretaceous（ca. 80–60 Ma）, and Miocene–present（since ca. 20 Ma）. These three stages regionally correspond to the LhasaEurasian collision during the Late Jurassic–Early Cretaceous（ca. 140–125 Ma）, the Lhasa-Gandise collision during the Late Cretaceous（ca. 80–70 Ma）, and a remote response to the India-Asian collision since ca. 55 Ma, respectively. These tectonic events also resulted in several regional unconformities between the J3/K1, K2/E, and E/N, and three large-scale hydrocarbon injection events in the Piedmont Thrust Belt（PTB）. Particularly, the hydrocarbon charge event during the Early Cretaceous resulted in the initial inundation and protection of paleo-uranium ore bodies that were formed during the Middle–Late Jurassic. The uplift and denudation of the PTB was extremely slow from 40 Ma onward due to a slight influence from the Himalayan orogeny. However, the uplift of the PTB was faster after the Miocene, which led to r展开更多
Although the factors affecting rural-to-urban migration have been discussed and analyzed in detail, few studies have examined the spatiotemporal dynamic characteristics of rural migrants’ employment and working-citie...Although the factors affecting rural-to-urban migration have been discussed and analyzed in detail, few studies have examined the spatiotemporal dynamic characteristics of rural migrants’ employment and working-cities in the post-immigrate era, which is essential for the citizenization and social integration of new-type urbanization in China. This study uses survey data from rural migration laborers across the eastern, central, and western China to construct a comprehensive labor migration stability index, and compares the determinants of the migration stability of rural labor among cities and industries using Geodetector. The results are as follows: 1) Compared with the midwestern cities, eastern cities have attracted younger and more skilled rural labor, and industries with higher technical content have higher migration stability among rural laborers. 2) Rural laborers more often adapt to changes by changing employment instead of changing working-cities. 3) The individual experiences of rural laborers and urban characteristics have significant impacts on the stability of migration, and family and societal guanxi(Chinese interpersonal relationships) enhance migration stability. 4) A unified labor market and convenient transportation have somewhat slowed industrial transfers and labor backflow. This study enhances our understanding of the roles of industrial transfer and new-type urbanization in shaping the labor geography landscape and provides policy implications for the promotion of people-oriented urbanization.展开更多
A close relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility,and protein tyrosine phosphatase 1B(PTP1B)may be involved in maintaining this homeostasi...A close relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility,and protein tyrosine phosphatase 1B(PTP1B)may be involved in maintaining this homeostasis.The stable residence of mesenchymal stem cells(MSCs)and endothelial cells(ECs)in their niches is closely related to the regulation of PTP1B.However,the exact role of the departure of MSCs and ECs from their niches during bone regeneration is largely unknown.Here,we show that the phosphorylation state of PTP1B tyrosine-152(Y152)plays a central role in initiating the departure of these cells from their niches and their subsequent recruitment to bone defects.Based on our previous design of a PTP1B Y152 region-mimicking peptide(152RM)that significantly inhibits the phosphorylation of PTP1B Y152,further investigations revealed that 152RM enhanced cell migration partly via integrinαvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ATF3.Moreover,152RM induced type H vessels formation by activating Notch signaling.Demineralized bone matrix(DBM)scaffolds were fabricated with mesoporous silica nanoparticles(MSNs),and 152RM was then loaded onto them by electrostatic adsorption.The DBM-MSN/152RM scaffolds were demonstrated to induce bone formation and type H vessels expansion in vivo.In conclusion,our data reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis,which may offer a potential therapeutic strategy for bone defects.展开更多
基金jointly conjugal supported by the Nuclear energy development project(grant No.H1142)Nation Pre-research Project(grant No.3210402)
文摘The Mesozoic–Cenozoic tectonic movement largely controls the northwest region of the Junggar Basin（NWJB）, which is a significant area for the exploration of petroleum and sandstone-type uranium deposits in China. This work collected six samples from this sedimentary basin and surrounding mountains to conduct apatite fission track（AFT） dating, and utilized the dating results for thermochronological modeling to reconstruct the uplift history of the NWJB and its response to hydrocarbon migration and uranium mineralization. The results indicate that a single continuous uplift event has occurred since the Early Cretaceous, showing spatiotemporal variation in the uplift and exhumation patterns throughout the NWJB. Uplift and exhumation initiated in the northwest and then proceeded to the southeast, suggesting that the fault system induced a post spread-thrust nappe into the basin during the Late Yanshanian. Modeling results indicate that the NWJB mountains have undergone three distinct stages of rapid cooling： Early Cretaceous（ca. 140–115 Ma）, Late Cretaceous（ca. 80–60 Ma）, and Miocene–present（since ca. 20 Ma）. These three stages regionally correspond to the LhasaEurasian collision during the Late Jurassic–Early Cretaceous（ca. 140–125 Ma）, the Lhasa-Gandise collision during the Late Cretaceous（ca. 80–70 Ma）, and a remote response to the India-Asian collision since ca. 55 Ma, respectively. These tectonic events also resulted in several regional unconformities between the J3/K1, K2/E, and E/N, and three large-scale hydrocarbon injection events in the Piedmont Thrust Belt（PTB）. Particularly, the hydrocarbon charge event during the Early Cretaceous resulted in the initial inundation and protection of paleo-uranium ore bodies that were formed during the Middle–Late Jurassic. The uplift and denudation of the PTB was extremely slow from 40 Ma onward due to a slight influence from the Himalayan orogeny. However, the uplift of the PTB was faster after the Miocene, which led to r
基金the auspices of the National Natural Science Foundation of China(No.41471469)the Key Project of National Natural Science Found of China(No.41930651)Sichuan Provincial Research Center for Philosophy and Social Sciences-Sichuan Rural Development Research Center(No.CR1908)。
文摘Although the factors affecting rural-to-urban migration have been discussed and analyzed in detail, few studies have examined the spatiotemporal dynamic characteristics of rural migrants’ employment and working-cities in the post-immigrate era, which is essential for the citizenization and social integration of new-type urbanization in China. This study uses survey data from rural migration laborers across the eastern, central, and western China to construct a comprehensive labor migration stability index, and compares the determinants of the migration stability of rural labor among cities and industries using Geodetector. The results are as follows: 1) Compared with the midwestern cities, eastern cities have attracted younger and more skilled rural labor, and industries with higher technical content have higher migration stability among rural laborers. 2) Rural laborers more often adapt to changes by changing employment instead of changing working-cities. 3) The individual experiences of rural laborers and urban characteristics have significant impacts on the stability of migration, and family and societal guanxi(Chinese interpersonal relationships) enhance migration stability. 4) A unified labor market and convenient transportation have somewhat slowed industrial transfers and labor backflow. This study enhances our understanding of the roles of industrial transfer and new-type urbanization in shaping the labor geography landscape and provides policy implications for the promotion of people-oriented urbanization.
基金This work was supported by grants from the National Natural Science Foundation of China(81974336 and 82002308).
文摘A close relationship has been reported to exist between cadherin-mediated cell-cell adhesion and integrin-mediated cell mobility,and protein tyrosine phosphatase 1B(PTP1B)may be involved in maintaining this homeostasis.The stable residence of mesenchymal stem cells(MSCs)and endothelial cells(ECs)in their niches is closely related to the regulation of PTP1B.However,the exact role of the departure of MSCs and ECs from their niches during bone regeneration is largely unknown.Here,we show that the phosphorylation state of PTP1B tyrosine-152(Y152)plays a central role in initiating the departure of these cells from their niches and their subsequent recruitment to bone defects.Based on our previous design of a PTP1B Y152 region-mimicking peptide(152RM)that significantly inhibits the phosphorylation of PTP1B Y152,further investigations revealed that 152RM enhanced cell migration partly via integrinαvβ3 and promoted MSCs osteogenic differentiation partly by inhibiting ATF3.Moreover,152RM induced type H vessels formation by activating Notch signaling.Demineralized bone matrix(DBM)scaffolds were fabricated with mesoporous silica nanoparticles(MSNs),and 152RM was then loaded onto them by electrostatic adsorption.The DBM-MSN/152RM scaffolds were demonstrated to induce bone formation and type H vessels expansion in vivo.In conclusion,our data reveal that 152RM contributes to bone formation by coupling osteogenesis with angiogenesis,which may offer a potential therapeutic strategy for bone defects.
