The expression and clinical significance of relevant cytokines in otitis media (OM) are discussed, and the alterations to the pathological state of the otitis media mucosa are further understood through the study of c...The expression and clinical significance of relevant cytokines in otitis media (OM) are discussed, and the alterations to the pathological state of the otitis media mucosa are further understood through the study of cytokine transduction pathways. More and more studies have shown that relevant cell proliferation and inflammation progression pathways play a role in the development of otitis media, such as the Jun amino-terminal protein kinase (JNK) mitogen-activated protein kinase (MAPK) signaling pathway, the NF-κB signaling pathway, and the PI3K/AKT/PTEN pathway, which are involved in the proliferation of the middle ear mucosa during otitis media, which affects the mucosal cilia, motor function, Eustachian tube function, and the mucosal ciliary function. These studies provide new ideas for the treatment of otitis media and further explore the feasibility of immunotherapy in the future treatment of otitis media. In this paper, we present a review of the latest research progress on the expression of various cytokines in otitis media.展开更多
目的探讨同期与分期行人工听骨链重建术在中耳胆脂瘤的应用。方法选取2018年11月-2021年3月于本院耳鼻喉科收治的49例(49耳)中耳胆脂瘤患者为研究对象,根据胆脂瘤病变情况采取同期和分期行人工听骨植入,随访3~18个月,记录术后干耳和术...目的探讨同期与分期行人工听骨链重建术在中耳胆脂瘤的应用。方法选取2018年11月-2021年3月于本院耳鼻喉科收治的49例(49耳)中耳胆脂瘤患者为研究对象,根据胆脂瘤病变情况采取同期和分期行人工听骨植入,随访3~18个月,记录术后干耳和术腔上皮化时间、鼓膜成活率的差异以及0.5、1、2、4KHz四个频率的纯音听阈平均值,比较术前、术后的气导(AC)、骨导(BC)、气骨导差(ABG)的变化。结果同期组术前平均AC(60.36±15.75)dB HL,ABG(27.86±8.92)dB HL,术后平均AC(48.69±11.51)dB HL,ABG(22.33±7.58)dB HL,术前术后比较P<0.05有统计学意义;分期组术前平均AC (59.61±19.48) dB HL,ABG (35.5±13.75) dB HL,术后平均AC (46.84±19.54) dB HL,术后ABG (26.15±14.61) dB HL,术前术后比较P<0.05有统计学意义。同期组出现1例真菌感染,1例听骨外露,其余鼓膜均成活且无并发症,分期组1例患者在首次手术后出现胆脂瘤的残留与复发合并鼓膜穿孔。结论同期与分期组术后听力均较术前提高,但2组术后听力比较差异无显著意义,我们发现中耳胆脂瘤侵犯中、下、后鼓室等隐蔽部位易造成首次手术无法彻底清除病变且造成鼓室黏膜炎症状态较重时行分期手术。展开更多
文摘The expression and clinical significance of relevant cytokines in otitis media (OM) are discussed, and the alterations to the pathological state of the otitis media mucosa are further understood through the study of cytokine transduction pathways. More and more studies have shown that relevant cell proliferation and inflammation progression pathways play a role in the development of otitis media, such as the Jun amino-terminal protein kinase (JNK) mitogen-activated protein kinase (MAPK) signaling pathway, the NF-κB signaling pathway, and the PI3K/AKT/PTEN pathway, which are involved in the proliferation of the middle ear mucosa during otitis media, which affects the mucosal cilia, motor function, Eustachian tube function, and the mucosal ciliary function. These studies provide new ideas for the treatment of otitis media and further explore the feasibility of immunotherapy in the future treatment of otitis media. In this paper, we present a review of the latest research progress on the expression of various cytokines in otitis media.
文摘目的探讨同期与分期行人工听骨链重建术在中耳胆脂瘤的应用。方法选取2018年11月-2021年3月于本院耳鼻喉科收治的49例(49耳)中耳胆脂瘤患者为研究对象,根据胆脂瘤病变情况采取同期和分期行人工听骨植入,随访3~18个月,记录术后干耳和术腔上皮化时间、鼓膜成活率的差异以及0.5、1、2、4KHz四个频率的纯音听阈平均值,比较术前、术后的气导(AC)、骨导(BC)、气骨导差(ABG)的变化。结果同期组术前平均AC(60.36±15.75)dB HL,ABG(27.86±8.92)dB HL,术后平均AC(48.69±11.51)dB HL,ABG(22.33±7.58)dB HL,术前术后比较P<0.05有统计学意义;分期组术前平均AC (59.61±19.48) dB HL,ABG (35.5±13.75) dB HL,术后平均AC (46.84±19.54) dB HL,术后ABG (26.15±14.61) dB HL,术前术后比较P<0.05有统计学意义。同期组出现1例真菌感染,1例听骨外露,其余鼓膜均成活且无并发症,分期组1例患者在首次手术后出现胆脂瘤的残留与复发合并鼓膜穿孔。结论同期与分期组术后听力均较术前提高,但2组术后听力比较差异无显著意义,我们发现中耳胆脂瘤侵犯中、下、后鼓室等隐蔽部位易造成首次手术无法彻底清除病变且造成鼓室黏膜炎症状态较重时行分期手术。
