Huperzine A(Hup-A) is a poorly water-soluble drug with low oral bioavailability. A selfmicroemulsifying drug delivery system(SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of H...Huperzine A(Hup-A) is a poorly water-soluble drug with low oral bioavailability. A selfmicroemulsifying drug delivery system(SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion(SPIP) technique and a chylomicron flow-blocking approach were used to study its intestinal absorption, mesenteric lymph node distribution and intestinal lymphatic uptake. The value of the area under the plasma concentration–time curve(AUC) of Hup-A SMEDDS was significantly higher than that of a Hup-A suspension(P <0.01).The absorption rate constant(K_a) and the apparent permeability coefficient(P_(app)) for Hup-A in different parts of the intestine suggested a passive transport mechanism, and the values of K_a and P_(app) of Hup-A SMEDDS in the ileum were much higher than those in other intestinal segments. The determination of Hup-A concentration in mesenteric lymph nodes can be used to explain the intestinal lymphatic absorption of Hup-A SMEDDS. For Hup-A SMEDDS, the values of AUC and maximum plasma concentration(C_(max)) of the blocking model were significantly lower than those of the control model(P<0.05). The proportion of lymphatic transport of Hup-A SMEDDS and Hup-A suspension were about 40% and 5%,respectively, suggesting that SMEDDS can significantly improve the intestinal lymphatic uptake and transport of Hup-A.展开更多
The ultrafine nickel particles/polyaniline nanocomposite materials were synthesized in situ polymerization by two step series W/O inverse microemulsion systems. As the first step, the ultrafine nickel nanoparticles wh...The ultrafine nickel particles/polyaniline nanocomposite materials were synthesized in situ polymerization by two step series W/O inverse microemulsion systems. As the first step, the ultrafine nickel nanoparticles whose diameter is 10～30 nm were prepared by the W/O inverse microemulsion systems and by the reduction. As the second step, the monomer aniline salt (AnH +Cl -)entered into the polar waterpools where contained nickel nanoparticles and the ultrafine nickel particles/Polyaniline nanocomposite materials whose diameter is 50～100 nm had been obtained by in situ polymerization. These nanocomposite materials were measured to characterize and the micromorphology, microstructure and physical interaction of the both ultrafine nickel particles and polyanilines were studied by transmission electron microscopy (TEM), XRD, infraed spectrum (IR).展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.8127410081573615)+2 种基金Natural Science Foundation of Anhui Province of China(Grant No.1408085QH189)Key Project for the Excellent Higher Education of Anhui Province of China(Grant No.2013SQRL019ZD)Research Project for the Science and Technology of Bozhou city of China(Grant No.BK2015005)
文摘Huperzine A(Hup-A) is a poorly water-soluble drug with low oral bioavailability. A selfmicroemulsifying drug delivery system(SMEDDS) was used to enhance the oral bioavailability and lymphatic uptake and transport of Hup-A. A single-pass intestinal perfusion(SPIP) technique and a chylomicron flow-blocking approach were used to study its intestinal absorption, mesenteric lymph node distribution and intestinal lymphatic uptake. The value of the area under the plasma concentration–time curve(AUC) of Hup-A SMEDDS was significantly higher than that of a Hup-A suspension(P <0.01).The absorption rate constant(K_a) and the apparent permeability coefficient(P_(app)) for Hup-A in different parts of the intestine suggested a passive transport mechanism, and the values of K_a and P_(app) of Hup-A SMEDDS in the ileum were much higher than those in other intestinal segments. The determination of Hup-A concentration in mesenteric lymph nodes can be used to explain the intestinal lymphatic absorption of Hup-A SMEDDS. For Hup-A SMEDDS, the values of AUC and maximum plasma concentration(C_(max)) of the blocking model were significantly lower than those of the control model(P<0.05). The proportion of lymphatic transport of Hup-A SMEDDS and Hup-A suspension were about 40% and 5%,respectively, suggesting that SMEDDS can significantly improve the intestinal lymphatic uptake and transport of Hup-A.
文摘The ultrafine nickel particles/polyaniline nanocomposite materials were synthesized in situ polymerization by two step series W/O inverse microemulsion systems. As the first step, the ultrafine nickel nanoparticles whose diameter is 10～30 nm were prepared by the W/O inverse microemulsion systems and by the reduction. As the second step, the monomer aniline salt (AnH +Cl -)entered into the polar waterpools where contained nickel nanoparticles and the ultrafine nickel particles/Polyaniline nanocomposite materials whose diameter is 50～100 nm had been obtained by in situ polymerization. These nanocomposite materials were measured to characterize and the micromorphology, microstructure and physical interaction of the both ultrafine nickel particles and polyanilines were studied by transmission electron microscopy (TEM), XRD, infraed spectrum (IR).
