Background DI-3-n-butylphthalide （NBP）, first isolated from the seeds of celery, showed efficacy in animal models of stroke. This study was a clinical trial to assess the efficacy and safety of NBP with a continuous...Background DI-3-n-butylphthalide （NBP）, first isolated from the seeds of celery, showed efficacy in animal models of stroke. This study was a clinical trial to assess the efficacy and safety of NBP with a continuous dose regimen among patients with acute ischemic stroke. Methods A randomized, double-blind, double-dummy trial enrolled 573 patients within 48 hours of onset of ischemic stroke in China. Patients were randomly assigned to receive a 14-day infusion of NBP followed by an NBP capsule, a 14- day infusion of NBP followed by aspirin, or a 14-day infusion of ozagrel followed by aspirin. The efficacy measures were Barthel index score and the modified Rankin scale （mRS） at day 90. Differences among the three groups on mRS were compared using X2 test of proportions （with two-sided e=0.05） and Logistic regression analysis was conducted to take the baseline National Institutes of Health Stroke Scale （NIHSS） score into consideration. Results Among the 535 subjects included in the efficacy analysis, 90-day treatment with NBP was associated with a significantly favorable outcome than 14-day treatment with ozagrel as measured by mRS （P 〈0.001）. No significant difference was found among the three groups on Barthel index at day 90. The rate of adverse events was similar among the three groups. Conclusions The 90-day treatment with NBP could improve outcomes at the third month after stroke. The NBP treatment （both intravenous and oral） is safe （ChiCTR-TRC-09000483）.展开更多
In a telemedicine diagnosis system,the emergence of 3D imaging enables doctors to make clearer judgments,and its accuracy also directly affects doctors’diagnosis of the disease.In order to ensure the safe transmissio...In a telemedicine diagnosis system,the emergence of 3D imaging enables doctors to make clearer judgments,and its accuracy also directly affects doctors’diagnosis of the disease.In order to ensure the safe transmission and storage of medical data,a 3D medical watermarking algorithm based on wavelet transform is proposed in this paper.The proposed algorithm employs the principal component analysis(PCA)transform to reduce the data dimension,which can minimize the error between the extracted components and the original data in the mean square sense.Especially,this algorithm helps to create a bacterial foraging model based on particle swarm optimization(BF-PSO),by which the optimal wavelet coefficient is found for embedding and is used as the absolute feature of watermark embedding,thereby achieving the optimal balance between embedding capacity and imperceptibility.A series of experimental results from MATLAB software based on the standard MRI brain volume dataset demonstrate that the proposed algorithm has strong robustness and make the 3D model have small deformation after embedding the watermark.展开更多
案例为基础的教学(case based learning,CBL)是一种以病例为核心,以问题为基础、以学生为主体、以教师为主导的讨论式教学方法,不仅具有PBL(problem based learning)的优点,又符合临床医学教育的特点。CBL教学方法在培养专业硕士及住院...案例为基础的教学(case based learning,CBL)是一种以病例为核心,以问题为基础、以学生为主体、以教师为主导的讨论式教学方法,不仅具有PBL(problem based learning)的优点,又符合临床医学教育的特点。CBL教学方法在培养专业硕士及住院医师的临床诊疗思维,继而转化为临床科研思维上具有重要作用,对于培养住院医师开展临床研究具有重要意义。目前,CBL教学法已成为医学教育教学的最实用、高效的方法之一。作者结合自身临床实践和带教的经历,浅谈CBL教学法在耳鼻咽喉头颈外科住院医师培训中的应用。展开更多
文摘Background DI-3-n-butylphthalide （NBP）, first isolated from the seeds of celery, showed efficacy in animal models of stroke. This study was a clinical trial to assess the efficacy and safety of NBP with a continuous dose regimen among patients with acute ischemic stroke. Methods A randomized, double-blind, double-dummy trial enrolled 573 patients within 48 hours of onset of ischemic stroke in China. Patients were randomly assigned to receive a 14-day infusion of NBP followed by an NBP capsule, a 14- day infusion of NBP followed by aspirin, or a 14-day infusion of ozagrel followed by aspirin. The efficacy measures were Barthel index score and the modified Rankin scale （mRS） at day 90. Differences among the three groups on mRS were compared using X2 test of proportions （with two-sided e=0.05） and Logistic regression analysis was conducted to take the baseline National Institutes of Health Stroke Scale （NIHSS） score into consideration. Results Among the 535 subjects included in the efficacy analysis, 90-day treatment with NBP was associated with a significantly favorable outcome than 14-day treatment with ozagrel as measured by mRS （P 〈0.001）. No significant difference was found among the three groups on Barthel index at day 90. The rate of adverse events was similar among the three groups. Conclusions The 90-day treatment with NBP could improve outcomes at the third month after stroke. The NBP treatment （both intravenous and oral） is safe （ChiCTR-TRC-09000483）.
基金supported,in part,by the Natural Science Foundation of Jiangsu Province under grant numbers BK20201136,BK20191401in part,by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)fund.
文摘In a telemedicine diagnosis system,the emergence of 3D imaging enables doctors to make clearer judgments,and its accuracy also directly affects doctors’diagnosis of the disease.In order to ensure the safe transmission and storage of medical data,a 3D medical watermarking algorithm based on wavelet transform is proposed in this paper.The proposed algorithm employs the principal component analysis(PCA)transform to reduce the data dimension,which can minimize the error between the extracted components and the original data in the mean square sense.Especially,this algorithm helps to create a bacterial foraging model based on particle swarm optimization(BF-PSO),by which the optimal wavelet coefficient is found for embedding and is used as the absolute feature of watermark embedding,thereby achieving the optimal balance between embedding capacity and imperceptibility.A series of experimental results from MATLAB software based on the standard MRI brain volume dataset demonstrate that the proposed algorithm has strong robustness and make the 3D model have small deformation after embedding the watermark.
文摘案例为基础的教学(case based learning,CBL)是一种以病例为核心,以问题为基础、以学生为主体、以教师为主导的讨论式教学方法,不仅具有PBL(problem based learning)的优点,又符合临床医学教育的特点。CBL教学方法在培养专业硕士及住院医师的临床诊疗思维,继而转化为临床科研思维上具有重要作用,对于培养住院医师开展临床研究具有重要意义。目前,CBL教学法已成为医学教育教学的最实用、高效的方法之一。作者结合自身临床实践和带教的经历,浅谈CBL教学法在耳鼻咽喉头颈外科住院医师培训中的应用。
