生物力学信号传递机制是从生物力学角度探讨其调控肿瘤恶性特征的关键,也是力学信号源头干预的理论实践基础.近期新型机械敏感离子通道蛋白Piezo1(piezo type mechanosensitive ion channel component 1,Piezo1)感应力学信号新途径的出...生物力学信号传递机制是从生物力学角度探讨其调控肿瘤恶性特征的关键,也是力学信号源头干预的理论实践基础.近期新型机械敏感离子通道蛋白Piezo1(piezo type mechanosensitive ion channel component 1,Piezo1)感应力学信号新途径的出现,为肿瘤细胞力学传递机制研究提供了新的视角.本文归纳总结了Piezo1介导力学信号参与肿瘤发生进展调控的新进展,包括诱导细胞癌变,调控细胞周期、增殖和侵袭转移,影响肿瘤细胞干性,血管新生,调控肿瘤免疫微环境等.展开更多
Colorectal cancer(CRC) development represents a multistep process starting with specific mutations that affect proto-oncogenes and tumour suppressor genes.These mutations confer a selective growth advantage to colonic...Colorectal cancer(CRC) development represents a multistep process starting with specific mutations that affect proto-oncogenes and tumour suppressor genes.These mutations confer a selective growth advantage to colonic epithelial cells that form first dysplastic crypts, and then malignant tumours and metastases. All these steps are accompanied by deep mechanical changes at the cellular and the tissue level. A growing consensus is emerging that such modifications are not merely a byproduct of the malignant progression, but they could play a relevant role in the cancer onset and accelerate its progression. In this review, we focus on recent studies investigating the role of the biomechanical signals in the initiation and the development of CRC. We show that mechanical cues might contribute to early phases of the tumour initiation by controlling the Wnt pathway, one of most important regulators of cell proliferation in various systems. We highlight how physical stimuli may be involved in the differentiation of non-invasive cells into metastatic variants and how metastatic cells modify their mechanical properties, both stiffness and adhesion, to survive the mechanical stress associated with intravasation, circulation and extravasation. A deep comprehension of these mechanical modifications may help scientist to define novel molecular targets for the cure of CRC.展开更多
文摘生物力学信号传递机制是从生物力学角度探讨其调控肿瘤恶性特征的关键,也是力学信号源头干预的理论实践基础.近期新型机械敏感离子通道蛋白Piezo1(piezo type mechanosensitive ion channel component 1,Piezo1)感应力学信号新途径的出现,为肿瘤细胞力学传递机制研究提供了新的视角.本文归纳总结了Piezo1介导力学信号参与肿瘤发生进展调控的新进展,包括诱导细胞癌变,调控细胞周期、增殖和侵袭转移,影响肿瘤细胞干性,血管新生,调控肿瘤免疫微环境等.
文摘Colorectal cancer(CRC) development represents a multistep process starting with specific mutations that affect proto-oncogenes and tumour suppressor genes.These mutations confer a selective growth advantage to colonic epithelial cells that form first dysplastic crypts, and then malignant tumours and metastases. All these steps are accompanied by deep mechanical changes at the cellular and the tissue level. A growing consensus is emerging that such modifications are not merely a byproduct of the malignant progression, but they could play a relevant role in the cancer onset and accelerate its progression. In this review, we focus on recent studies investigating the role of the biomechanical signals in the initiation and the development of CRC. We show that mechanical cues might contribute to early phases of the tumour initiation by controlling the Wnt pathway, one of most important regulators of cell proliferation in various systems. We highlight how physical stimuli may be involved in the differentiation of non-invasive cells into metastatic variants and how metastatic cells modify their mechanical properties, both stiffness and adhesion, to survive the mechanical stress associated with intravasation, circulation and extravasation. A deep comprehension of these mechanical modifications may help scientist to define novel molecular targets for the cure of CRC.
