In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (M...In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg);however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.展开更多
Diabetes mellitus is a major public health problem globally. It is the cause of serious and sometimes life-threatening complications leading to death. It is one of the most common non communicable diseases and leading...Diabetes mellitus is a major public health problem globally. It is the cause of serious and sometimes life-threatening complications leading to death. It is one of the most common non communicable diseases and leading cause of death in most developed countries including Bangladesh. It is associated with the increased risk of microvascular (nephropathy and retinopathy), macrovascular (cardiovascular diseases, stroke) and other mixed (cataract, pulmonary tuberculosis, foot ulcer etc.) complications. The aim of this study was to determine the risk factors related to diabetes complications and to propose competing risk models for analyzing complications of diabetes mellitus. We study 2887 diabetic patients from the BIRDEM registry record books for the period from 1984 to 1997 who have at least two follow-up visits and who are free from complications at the first visit. The data on variables such as 2-hBG, age, sex, family history of diabetes, area of residence, educational level, BMI, SBP, DBP and treatment status are obtained. Also, the time from the diagnosis of type 2 diabetes mellitus (T2DM) to the occurrence of complications was recorded. We use the competing risk hazard model and examined the potential risk factors for determining the development of such complications. This study reveals that increase in blood pressure is a potential risk factor for CHD and nephropathy in T2DM. We also found that male and illiterate patients are more affected by nephropathy. In our study, we also revealed that female and illiterate patients are also more influenced by cataract.展开更多
There have been data showing that central cholecystokinin oetapeptide (CCK-8) could antagonize the analgesia induced by exogenous and endogenoust opioid peptides. Recently, we found that the hypotension produced by op...There have been data showing that central cholecystokinin oetapeptide (CCK-8) could antagonize the analgesia induced by exogenous and endogenoust opioid peptides. Recently, we found that the hypotension produced by opioid peptides could also be reversed by central administration of CCK-8 (Mei Lin et al., unpublished result). The above-mentioned results either in physiology or in pharmacology suggested that CCK-8 appeared to have a potent antagonistic effect against opioid peptides and may be the endogenous anti-opioid substance.展开更多
文摘In this study, we investigated whether increases in hippocampal blood flow (HBF) by tooth pulp stimulation (TPS) are mediated via the activation of cyclooxygenase-2 (COX-2). We measured mean arterial blood pressure (MABP) and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal (i.p.) administration of etodolac (10 mg/kg);however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.
文摘Diabetes mellitus is a major public health problem globally. It is the cause of serious and sometimes life-threatening complications leading to death. It is one of the most common non communicable diseases and leading cause of death in most developed countries including Bangladesh. It is associated with the increased risk of microvascular (nephropathy and retinopathy), macrovascular (cardiovascular diseases, stroke) and other mixed (cataract, pulmonary tuberculosis, foot ulcer etc.) complications. The aim of this study was to determine the risk factors related to diabetes complications and to propose competing risk models for analyzing complications of diabetes mellitus. We study 2887 diabetic patients from the BIRDEM registry record books for the period from 1984 to 1997 who have at least two follow-up visits and who are free from complications at the first visit. The data on variables such as 2-hBG, age, sex, family history of diabetes, area of residence, educational level, BMI, SBP, DBP and treatment status are obtained. Also, the time from the diagnosis of type 2 diabetes mellitus (T2DM) to the occurrence of complications was recorded. We use the competing risk hazard model and examined the potential risk factors for determining the development of such complications. This study reveals that increase in blood pressure is a potential risk factor for CHD and nephropathy in T2DM. We also found that male and illiterate patients are more affected by nephropathy. In our study, we also revealed that female and illiterate patients are also more influenced by cataract.
文摘There have been data showing that central cholecystokinin oetapeptide (CCK-8) could antagonize the analgesia induced by exogenous and endogenoust opioid peptides. Recently, we found that the hypotension produced by opioid peptides could also be reversed by central administration of CCK-8 (Mei Lin et al., unpublished result). The above-mentioned results either in physiology or in pharmacology suggested that CCK-8 appeared to have a potent antagonistic effect against opioid peptides and may be the endogenous anti-opioid substance.
