背景:材料生物力学是通过材料学方法探究生物材料的力学微环境,属于可持续发展的前沿学科。目的:探讨材料生物力学当前的研究热点与发展态势,为后续研究提供理论参考。方法:基于CiteSpace文献计量软件以Web of Science核心数据库中2012-...背景:材料生物力学是通过材料学方法探究生物材料的力学微环境,属于可持续发展的前沿学科。目的:探讨材料生物力学当前的研究热点与发展态势,为后续研究提供理论参考。方法:基于CiteSpace文献计量软件以Web of Science核心数据库中2012-2022年间3182篇材料生物力学文献生成关键词共现和聚类、突现词探测等知识图谱,进行可视化分析。结果与结论:近十年材料生物力学研究发文量呈增加趋势,美国、中国、德国是发文量前三的国家,研究主要集中于各大高校和科研机构,具有显著的聚集性。材料生物力学研究主要涉及材料科学、生物医学工程、体育学等学科,有限元分析、材料特性、生物材料的力学表现和分子生物力学是学者关注和研究的重点。目前,材料生物力学领域研究集中于利用有限元分析法计算不同生物医用材料在不同载荷、机械性能等条件下的力学响应,为运动疾病的预防、手术规划、术后康复等提供参考。无机材料的应用和分子信号的运输方式可能是未来研究的前景.展开更多
应用信息可视化软件CiteSpace V及其辅助工具VOSviewer对分子筛领域的27519篇SCI英文文献进行分析,结合Web of Science(WOS)核心集中的SCI-E,SSCI,CPCI-S数据源,时间跨度为2000-2019年,研究了全球范围内相应文献的时空分布。基于文献计...应用信息可视化软件CiteSpace V及其辅助工具VOSviewer对分子筛领域的27519篇SCI英文文献进行分析,结合Web of Science(WOS)核心集中的SCI-E,SSCI,CPCI-S数据源,时间跨度为2000-2019年,研究了全球范围内相应文献的时空分布。基于文献计量和统计分析,生成了相应的期刊共被引知识图谱、作者合作知识图谱、作者共被引知识图谱、关键词共现知识图谱以及参考文献共被引知识图谱,分析并得出分子筛领域的研究现状与新兴趋势。结果表明:在世界范围内,该领域近9 a来的研究热度逐年攀升,高产期刊和高被引期刊均为Microporous and Mesoporous Materials,中美2国是开展分子筛研究的主要国家,分子筛领域的高产研究机构为中国科学院。同时,还总结了分子筛领域的主要研究团队和高影响力学者。通过对近10 a文献关键词的共现分析和参考文献的共被引分析,结果发现:纳米微孔沸石的催化机理与应用和分子筛对气体吸附分离性能的分析是当今国际上该领域的研究热点,分子筛金属骨架的改性对催化性能的影响和分子筛在生物质研究领域中的应用是目前国际研究的新兴趋势。展开更多
Polyvinyl alcohol(PVA) embolization particles, currently used in clinical practice, have good expansibility and are capable of permanent embolization. However, the lack of adhesion of embolization particles contribute...Polyvinyl alcohol(PVA) embolization particles, currently used in clinical practice, have good expansibility and are capable of permanent embolization. However, the lack of adhesion of embolization particles contributes to facilitated recanalization after embolization, while the lack of visualization facilitates misembolization. At present, embolization materials with good expansion, adhesion, and visualization potential are urgently required in clinical practice. Here, we report the development of PVA/gelatin/iohexol(I) fiber blocks as a novel embolization material for liver embolization in rats. In our work, electrospun PVA/gelatin/I nanofibrous mats were first prepared, homogenized, centrifuged in a gradient manner, and freeze-dried to obtain fiber blocks(fiber diameter =296.2 ± 74.23 nm, length 99.6 ± 17.0 μm × width 46.9 ± 13.3 μm). The fiber blocks exhibited excellent cytocompatibility and hemocompatibility. Fiber blocks with a PVA/gelatin/I mass ratio of 8:2:10 were selected due to their excellent expansibility and adhesive properties. The PVA/gelatin/I fiber blocks display excellent liver embolic effects and computed tomography(CT) imaging potential due to a combination of the following characteristics: expansibility of PVA and gelatin, adhesive property of gelatin, and CT imaging potential of I. The developed fiber block material is an embolic material that may potentially be used in interventional medicine.展开更多
文摘背景:材料生物力学是通过材料学方法探究生物材料的力学微环境,属于可持续发展的前沿学科。目的:探讨材料生物力学当前的研究热点与发展态势,为后续研究提供理论参考。方法:基于CiteSpace文献计量软件以Web of Science核心数据库中2012-2022年间3182篇材料生物力学文献生成关键词共现和聚类、突现词探测等知识图谱,进行可视化分析。结果与结论:近十年材料生物力学研究发文量呈增加趋势,美国、中国、德国是发文量前三的国家,研究主要集中于各大高校和科研机构,具有显著的聚集性。材料生物力学研究主要涉及材料科学、生物医学工程、体育学等学科,有限元分析、材料特性、生物材料的力学表现和分子生物力学是学者关注和研究的重点。目前,材料生物力学领域研究集中于利用有限元分析法计算不同生物医用材料在不同载荷、机械性能等条件下的力学响应,为运动疾病的预防、手术规划、术后康复等提供参考。无机材料的应用和分子信号的运输方式可能是未来研究的前景.
文摘应用信息可视化软件CiteSpace V及其辅助工具VOSviewer对分子筛领域的27519篇SCI英文文献进行分析,结合Web of Science(WOS)核心集中的SCI-E,SSCI,CPCI-S数据源,时间跨度为2000-2019年,研究了全球范围内相应文献的时空分布。基于文献计量和统计分析,生成了相应的期刊共被引知识图谱、作者合作知识图谱、作者共被引知识图谱、关键词共现知识图谱以及参考文献共被引知识图谱,分析并得出分子筛领域的研究现状与新兴趋势。结果表明:在世界范围内,该领域近9 a来的研究热度逐年攀升,高产期刊和高被引期刊均为Microporous and Mesoporous Materials,中美2国是开展分子筛研究的主要国家,分子筛领域的高产研究机构为中国科学院。同时,还总结了分子筛领域的主要研究团队和高影响力学者。通过对近10 a文献关键词的共现分析和参考文献的共被引分析,结果发现:纳米微孔沸石的催化机理与应用和分子筛对气体吸附分离性能的分析是当今国际上该领域的研究热点,分子筛金属骨架的改性对催化性能的影响和分子筛在生物质研究领域中的应用是目前国际研究的新兴趋势。
基金the State Key Laboratory forModification of Chemical Fibers and Polymer Materials,Donghua Universitythe Science and Technology Commission of Shanghai Municipality(19XD1400100 and 20520710300)+1 种基金the 2019th Shanghai Medical Guide Science and Technology Supporting Project(19411971000)the Science and Technology Research Project from the Science and Technology Department of Henan Province in 2020(202102310539)。
文摘Polyvinyl alcohol(PVA) embolization particles, currently used in clinical practice, have good expansibility and are capable of permanent embolization. However, the lack of adhesion of embolization particles contributes to facilitated recanalization after embolization, while the lack of visualization facilitates misembolization. At present, embolization materials with good expansion, adhesion, and visualization potential are urgently required in clinical practice. Here, we report the development of PVA/gelatin/iohexol(I) fiber blocks as a novel embolization material for liver embolization in rats. In our work, electrospun PVA/gelatin/I nanofibrous mats were first prepared, homogenized, centrifuged in a gradient manner, and freeze-dried to obtain fiber blocks(fiber diameter =296.2 ± 74.23 nm, length 99.6 ± 17.0 μm × width 46.9 ± 13.3 μm). The fiber blocks exhibited excellent cytocompatibility and hemocompatibility. Fiber blocks with a PVA/gelatin/I mass ratio of 8:2:10 were selected due to their excellent expansibility and adhesive properties. The PVA/gelatin/I fiber blocks display excellent liver embolic effects and computed tomography(CT) imaging potential due to a combination of the following characteristics: expansibility of PVA and gelatin, adhesive property of gelatin, and CT imaging potential of I. The developed fiber block material is an embolic material that may potentially be used in interventional medicine.
