Background There has been an increase in the incidence of breast cancer in China, but no definite risk and protective factors for breast cancer have been identified in Chinese females. This study was designed to ident...Background There has been an increase in the incidence of breast cancer in China, but no definite risk and protective factors for breast cancer have been identified in Chinese females. This study was designed to identify the risk factors for female breast cancer in North and East China.展开更多
We performed a long range acoustic propagation experiment in the South China Sea(SCS) in November 2004.The environment of the experiment was with an isothermal sound speed profile,where influence of water volume fluct...We performed a long range acoustic propagation experiment in the South China Sea(SCS) in November 2004.The environment of the experiment was with an isothermal sound speed profile,where influence of water volume fluctuation was small,meaning that bottom parameters can be well estimated from acoustic signals.We inverted the acoustic parameters of sediment by using a hybrid inversion scheme that combines the matched field processing inversion with Hamilton sediment empirical relationship and transmission loss data.The numerical results show excellent agreement with the experiment data,indicating validity of the inverted parameters.展开更多
In this paper,the internal flow field in a centrifugal pump working at the design flow rate operating condition has been measured using the particle image velocimetry(PIV)technique with the fluorescent particles and t...In this paper,the internal flow field in a centrifugal pump working at the design flow rate operating condition has been measured using the particle image velocimetry(PIV)technique with the fluorescent particles and the index-matched fluid technology.The index-marching fluid with the same refractive index as the transparent material has been prepared and applied in the present test of pump with geometrical complex walls.The comparison between velocity distributions of PIV results both with and without fluorescent particles,as well as with and without index-marching fluid are conducted to find the differences.The DES(Detached Eddy Simulation)has been employed to calculate the three-dimensional unsteady turbulent flow in the pump to examine and to certify the PIV measurement results.The DES results of instantaneous flow velocity fields agree with PIV test results with fluorescent particles and index-marching fluid.It is necessary to perform the PIV measurement of pumps with fluorescent seeds and index-marching fluid in order to get exact results.The experimental results show the distributions of velocity,steamlines,and the principal Reynolds normal stress(PRNS)and the principal Reynolds shear stress(PRSS).展开更多
AIM: To compare shortand long-term outcomes of laparoscopy-assisted and open distal gastrectomy for gastric cancer. METHODS: A retrospective study was performed by comparing the outcomes of 54 patients who underwent l...AIM: To compare shortand long-term outcomes of laparoscopy-assisted and open distal gastrectomy for gastric cancer. METHODS: A retrospective study was performed by comparing the outcomes of 54 patients who underwent laparoscopy-assisted distal gastrectomy (LADG) with those of 54 patients who underwent open distal gastrectomy (ODG) between October 2004 and October 2007. The patients' demographic data (age and gender), date of surgery, extent of lymphadenectomy, and differentiation and tumor-node-metastasis stage of the tumor were examined. The operative time, intraoperative blood loss, postoperative recovery, complications, pathological findings, and follow-up data were compared between the two groups.RESULTS: The mean operative time was significantly longer in the LADG group than in the ODG group (259.3 ± 46.2 min vs 199.8 ± 40.85 min; P < 0.05), whereas intraoperative blood loss and postoperative complications were significantly lower (160.2 ± 85.9 mL vs 257.8 ± 151.0 mL; 13.0% vs 24.1%, respectively, P < 0.05). In addition, the time to first flatus, time to initiate oral intake, and postoperative hospital stay were significantly shorter in the LADG group than in the ODG group (3.9 ± 1.4 d vs 4.4 ± 1.5 d; 4.6 ± 1.2 d vs 5.6 ± 2.1 d; and 9.5 ± 2.7 d vs 11.1 ± 4.1 d, respectively; P < 0.05). There was no significant difference between the LADG group and ODG group with regard to the number of harvested lymph nodes. The median followup was 60 mo (range, 5-97 mo). The 1-, 3-, and 5-year disease-free survival rates were 94.3%, 90.2%, and 76.7%, respectively, in the LADG group and 89.5%, 84.7%, and 82.3%, respectively, in the ODG group. The 1-, 3-, and 5-year overall survival rates were 98.0%, 91.9%, and 81.1%, respectively, in the LADG group and 91.5%, 86.9%, and 82.1%, respectively, in the ODG group. There was no significant difference between the two groups with regard to the survival rate. CONCLUSION: LADG is suitable and minimally invasive for treating distal gastric cancer and can achieve similar long-t展开更多
In this paper,we investigate the matched filter based spectrum sensing in a more reasonable cognitive radio(CR) scenario when the primary user(PU) has more than one transmit power levels,as regulated in most standards...In this paper,we investigate the matched filter based spectrum sensing in a more reasonable cognitive radio(CR) scenario when the primary user(PU) has more than one transmit power levels,as regulated in most standards,i.e.,IEEE 802.11 Series,GSM,LTE,LTE-A,etc.This new multiple primary transmit power(MPTP) scenario is specialized by two different targets:detecting the presence of PU and identifying the power level.Compared to the traditional binary sensing where only the presence of PU is checked,SU may attain more information about the primary network(making CR more "intelligent") and design the subsequent optimization strategy.The key technology is the multiple hypothesis testing as opposed to the traditional binary hypothesis testing.We discuss two situations under whether the channel phase is known or not,and we derive the closed form solutions for decision regions and several performance metrics,from which some interesting phenomenons are observed and the related discussions are presented.Numerical examples are provided to corroborate the proposed studies.展开更多
Background Little is known about the feasibility and safety of laparoscopy-assisted total gastrectomy （LATG） with extended lymphadenectomy in patients with advanced gastric cancer （AGC）.This study compared the tec...Background Little is known about the feasibility and safety of laparoscopy-assisted total gastrectomy （LATG） with extended lymphadenectomy in patients with advanced gastric cancer （AGC）.This study compared the technical feasibility,safety,and oncologic efficacy of LATG with open total gastrectomy （OTG） for AGC without serosa invasion.Methods From January 2009 to December 2011,235 patients underwent LATG and 153 patients underwent OTG for AGC without serosa invasion.Age,gender,and depth of invasion （pT2 and pT3） were matched by propensity scoring,and 116 patients （58 LATG and 58 OTG） were selected for analysis.Their clinicopathologic characteristics,postoperative outcomes,and survival were compared.Results There was no significant difference in clinicopathologic characteristics between the two propensity-matched groups.Median number of lymph nodes per patient was 29,and the mean number of retrieved lymph nodes was similar in the LATG and OTG groups （30.8±10.2 vs.29.0±8.3）.Peri-operative characteristics,operation time,number of transfused units per patient,and time to resumption of activities were similar in the two groups; while blood loss,times to first flatus and resumption of soft diet,and post-operative stay were significantly lower in the LATG group （P ＜0.05,respectively）.Rates of post-operative complications （12.1％ vs.15.5％） and postoperative mortality （0％ vs.1.7％）,as well as cumulative survival rates,were similar.Conclusions LATG with D2 lymphadenectomy is a safe and feasible procedure for AGC patients without serosa invasion.ProsPective.multicenter,randomized trials are needed to confirm the efficacy of LATG in this patient population.展开更多
In order to compare the effect between haploidentical(HID) stem cell transplantation(HSCT) and matched sibling donor(MSD)stem cell transplantation for high-risk acute myeloid leukemia(AML) in first complete remission ...In order to compare the effect between haploidentical(HID) stem cell transplantation(HSCT) and matched sibling donor(MSD)stem cell transplantation for high-risk acute myeloid leukemia(AML) in first complete remission status(CR1), we retrospectively studied 170 cases who received stem cell transplantation from Jan 2008 to Jul 2015 in Peking University People's Hospital. We divided all cases into MSD group(43 cases) and HID(127 cases) group. Patients in HID and MSD group displayed similar baseline characteristics except for age distribution. There were no statistic differences for overall survival(OS), cumulative incidence of relapse, leukemia free survival(LFS), transplantation related mortality(TRM) between HID and MSD group. The 3-year OS, LFS for all patients was 63.9% and 59.7% respectively. Multivariate analysis showed that grade III-IV acute graft versus host disease(aGVHD) was an independent risk factor for treatment related mortality(HR=8.134, 95% CI:3.210–20.611, P<0.001), monosomy/complex chromosomal karyotype and white blood cell count more than 50×109 L-1 were two independent factors for relapse(HR=1.533, 95% CI: 1.040–2.260, P=0.031)(HR=1.004, 95% CI: 1.001–1.008, P=0.015).Grade III-IV aGVHD was an independent factor for mortality(HR=3.184, 95% CI: 1.718–5.902, P<0.001). These results demonstrated some risk factors for high-risk AML leukemia transplantation and indicated for AML patients in CR1 status, haplo stem cell transplantation could have the same therapeutic effect as MSD transplantation.展开更多
We present a high-resolution seismic catalog for the 2021 M_(S)6.4/M_(W)6.1 Yangbi sequence.The catalog has a time range of 2021-05-01 to 2021-05-28,and contains~8,000 well located events.It captures the features of t...We present a high-resolution seismic catalog for the 2021 M_(S)6.4/M_(W)6.1 Yangbi sequence.The catalog has a time range of 2021-05-01 to 2021-05-28,and contains~8,000 well located events.It captures the features of the whole foreshock sequence and the early aftershocks.We designed a detection strategy incorporating both an artificial intelligent(AI)picker and a matched filter algorithm.Here,we adopt a hybrid AI method incorporating convolutional and recurrent neural network(CNN&RNN)for event detection and phase picking respectively(i.e.CERP),a light-weight AI picker that can be trained with small volume of data.CERP is first trained with detections from a STA/LTA and Kurtosis-based method called PAL,and then construct a rather complete template set of~4,000 events.Finally,the matched filter algorithm MESS augments the initial detections and measures differential travel times with cross-correlation,which finally results in precise relocation.This process gives 9,026 detections,among which 7,943 events can be well relocated.The catalog shows as expected power-law distribution of frequency magnitude and reveals detailed pattern of seismicity evolution.The main features are:(1)the foreshock sequence images simple fault geometry with consistent strike,but also show a variable event depth along strike;(2)the mainshock ruptures the same fault of the foreshock sequence and activate conjugate faults further to the southeast;(3)complex seismicity are developed in the post-seismic period,indicating complex triggering mechanisms.Thus,our catalog provides a reliable basis for further investigations,such as b-value studies,rupture process,and triggering relations.展开更多
Wnt signaling plays an important role in the bone development and remodeling. The Wnt antagonist Dkk-1 is a potent inhibitor of bone formation. The aims of this study were firstly to compare the serum Dkk-1 levels in ...Wnt signaling plays an important role in the bone development and remodeling. The Wnt antagonist Dkk-1 is a potent inhibitor of bone formation. The aims of this study were firstly to compare the serum Dkk-1 levels in postmenopausal osteoporosis patients with age-matched healthy controls, and secondly, to assess the possible relationship between Dkk-1 and β-catenin, sclerostin, or bone turnover markers [CTX, PINP, N-MID-OT and 25（OH）D] in the setting of postmenopausal osteoporosis. A total of 350 patients with postmenopausal osteoporosis and 150 age-matched healthy controls were enrolled, and the serum levels of Dkk-1, β-catenin, sclerostin, OPG, and RANKL were detected by ELISA, and bone turnover markers [CTX, PINP, N-MID-OT and 25（OH）D] were measured by Roche electrochemiluminescence system in two groups. Serum Dkk-1 levels were significantly higher in postmenopausal osteoporosis group than in control group（P〈0.001）. Univariate analyses revealed that serum Dkk-1 levels were weakly negatively correlated to β-catenin（r=–0.161, P=0.003） and OPG（r=–0.106, P=0.047）, while multiple regression analysis showed a negative correlation between serum Dkk-1 levels with β-catenin（β=–0.165, P=0.009） and BMD（β=–0.139, P=0.027）, and a positive correlation between serum Dkk-1 levels and CTX（β=0.122, P=0.040） in postmenopausal osteoporosis group. No similar correlations ware observed in control group. The results provided evidence for the role of Dkk-1 in bone metabolism and demonstrated the link of Dkk-1 and Wnt/β-catenin in some ways.展开更多
Multi-angle synthetic aperture radar（SAR） image matching is very challenging, because the same object may cause different backscattering patterns, heavily depending on the radar incident angle. A technique based on ...Multi-angle synthetic aperture radar（SAR） image matching is very challenging, because the same object may cause different backscattering patterns, heavily depending on the radar incident angle. A technique based on the relations between the invariant positions of ground targets among the reference and sensed images is proposed to accommodate the nonmatching patterns. It involves a target extraction using wavelet coefficient fusion, as well as a geometric voting matching routine for searching the matched control points（CPs） in the reference and sensed images, respectively. To accelerate the speed of the search, a robust, rapidly corresponding CPs determination strategy is exploited by utilizing the global spatial transformation model, as well as a procedure of outlier removal to ensure the desired accuracy. Meanwhile, the positions of the matched point pairs are relocated using mutual information. The final warping of the images according to the CPs is performed by using a polynomial function. The results show the possibility of matching multi-angle SAR images in general cases.展开更多
In order to improve the ability to localize a source in an uncertain acoustic environment,a Bayesian approach,referred to here as Bayesian localization is used by including the environment in the parameter search spac...In order to improve the ability to localize a source in an uncertain acoustic environment,a Bayesian approach,referred to here as Bayesian localization is used by including the environment in the parameter search space.Genetic algorithms are used for the parameter optimization.This method integrates the a posterior probability density（PPD） over environmental parameters to obtain a sequence of marginal probability distributions over source range and depth,from which the most-probable source location and localization uncertainties can be extracted.Considering that the seabed density and attenuation are less sensitive to the objective function of matched field processing,we utilize the empirical relationship to invert those parameters indirectly.The broadband signals recorded by a vertical line array in a Yellow Sea experiment in 2000 are processed and analyzed.It was found that,the Bayesian localization method that incorporates the environmental variability into the processor,made it robust to the uncertainty in the ocean environment.In addition,using the empirical relationship could enhance the localization accuracy.展开更多
We study an finite-difference time-domain (FDTD) system of uniaxial perfectly matched layer (UPML) method for electromagnetic scattering problems. Particularly we analyze the discrete initial-boundary value problems o...We study an finite-difference time-domain (FDTD) system of uniaxial perfectly matched layer (UPML) method for electromagnetic scattering problems. Particularly we analyze the discrete initial-boundary value problems of the transverse magnetic mode (TM) to Maxwell's equations with Yee's algorithm. An exterior domain in two spacial dimension is truncated by a square with a perfectly matched layer filled by a certain artificial medium. Besides, an artificial boundary condition is imposed on the outer boundary of the UPML. Using energy method, we obtain the stability of this FDTD system on the truncated domain. Numerical experiments are designed to approve the theoretical analysis.展开更多
A Schwann cell has regenerative capabilities and is an important cell in the peripheral nervous system.This microarray study is part of a bioinformatics study that focuses mainly on Schwann cells. Microarray data prov...A Schwann cell has regenerative capabilities and is an important cell in the peripheral nervous system.This microarray study is part of a bioinformatics study that focuses mainly on Schwann cells. Microarray data provide information on differences between microarray-based and experiment-based gene expression analyses. According to microarray data, several genes exhibit increased expression(fold change) but they are weakly expressed in experimental studies(based on morphology, protein and mRNA levels). In contrast, some genes are weakly expressed in microarray data and highly expressed in experimental studies;such genes may represent future target genes in Schwann cell studies. These studies allow us to learn about additional genes that could be used to achieve targeted results from experimental studies. In the current big data study by retrieving more than 5000 scientific articles from PubMed or NCBI, Google Scholar, and Google, 1016(up-and downregulated) genes were determined to be related to Schwann cells. However,no experiment was performed in the laboratory; rather, the present study is part of a big data analysis. Our study will contribute to our understanding of Schwann cell biology by aiding in the identification of genes.Based on a comparative analysis of all microarray data, we conclude that the microarray could be a good tool for predicting the expression and intensity of different genes of interest in actual experiments.展开更多
For global navigation satellite system （GNSS） signals in Gaussian and Rayleigh fading channel, a novel signal detection algorithm is proposed. Under the low frequency uncertainty case, after performing discrete cosi...For global navigation satellite system （GNSS） signals in Gaussian and Rayleigh fading channel, a novel signal detection algorithm is proposed. Under the low frequency uncertainty case, after performing discrete cosine transform （DCT） to the outputs of the partial matched filter （PMF） for every antenna, the high order com- ponents in the transforming domain will be filtered, then the equalgain （EG） combination for the inverse discrete cosine transform （IDCT） reconstructed signal would be done subsequently. Thus, due to the different frequency distribution characteristics between the noise and signals, after EG combination, the energy of signals has almost no loss and the noise energy is greatly reduced. The theoretical analysis and simulation results show that the detection algorithm can effectively improve the signal-to-noise ratio of the captured signal and increase the probability of detection under the same false alarm probability. In addition, it should be pointed out that this method can also be applied to Rayleigh fading channels with moving antenna.展开更多
Composite electromagnetic scattering from a two-dimensional （2D） ship-like target on a one-dimensional sea surface is investigated by using the finite-difference time-domain （FDTD） method. A uniaxial perfectly mat...Composite electromagnetic scattering from a two-dimensional （2D） ship-like target on a one-dimensional sea surface is investigated by using the finite-difference time-domain （FDTD） method. A uniaxial perfectly matched layer is adopted for truncation of FDTD lattices.The FDTD updated equations can be used for the total computation domain by choosing the uniaxial parameters properly. To validate the proposed numerical technique,a 2D infinitely long cylinder over the sea surface is taken into account first.The variation of angular distribution of the scattering changing with incident angle is calculated. The results show good agreement with the conventional moment method. Finally,the influence of the incident angle,the polarization,and the size of the ship-like target on the composite scattering coefficient is discussed in detail.展开更多
AIM: To present the radiological results of total knee arthroplasty(TKA) with use of patient specific matched guides(PSG) from different manufacturer in patients suffering from severe osteoarthritis of the knee joint....AIM: To present the radiological results of total knee arthroplasty(TKA) with use of patient specific matched guides(PSG) from different manufacturer in patients suffering from severe osteoarthritis of the knee joint.METHODS: This study describes the results of 57 knees operated with 4 different PSG systems and a group operated with conventional instrumentation(n = 60) by a single surgeon. The PSG systems were compared with each other and subdivided into cut- and pin PSG. The biomechanical axis [hip-knee-ankle angle(HKA)], varus/valgus of the femur [frontal femoral component(FFC)] and tibia(frontal tibial component) component, flexion/extension of the femur [flexion/extension of the femur component(LFC)] and posterior slope of the tibia [lateral tibial component(LTC)] component were evaluated on long-leg standing and lateral X-rays. A percentage of > 3° deviation was seen as an outlier. RESULTS: The inter class correlation coefficient(ICC) revealed that radiographic measurements between both assessors were reliable(ICC > 0.8). Fisher exact test was used to test differences of proportions. The percentage of outliers of the HKA-axis was comparable between both the PSG and conventional groups(12.28% vs 18.33%, P < 0.424) and the cut- and pin PSG groups(14.3% vs 10.3%, P < 1.00). The percentage of outliers of the FFC(0% vs 18.33%, P < 0.000), LFC(15.78% vs 58.33%, P < 0.000) and LTC(15.78% vs 41.67%, P < 0.033) were significant different in favour of the PSGgroup. There were no significant differences regarding the outliers between the individual PSG systems and the PSG group subdivided into cut- and pin PSG.CONCLUSION: PSG for TKA show significant less outliers compared to the conventional technique. These single surgeon results suggest that PSG are ready for primetime.展开更多
文摘Background There has been an increase in the incidence of breast cancer in China, but no definite risk and protective factors for breast cancer have been identified in Chinese females. This study was designed to identify the risk factors for female breast cancer in North and East China.
基金Supported by the Knowledge Innovation Program of the Chinese Academy of Sciences (No.KZCX1-YW-12-02)the National Natural Science Foundation of China (Nos.10974218 and 10734100)
文摘We performed a long range acoustic propagation experiment in the South China Sea(SCS) in November 2004.The environment of the experiment was with an isothermal sound speed profile,where influence of water volume fluctuation was small,meaning that bottom parameters can be well estimated from acoustic signals.We inverted the acoustic parameters of sediment by using a hybrid inversion scheme that combines the matched field processing inversion with Hamilton sediment empirical relationship and transmission loss data.The numerical results show excellent agreement with the experiment data,indicating validity of the inverted parameters.
基金supported by the National Natural Science Foundation of China(Grant No.10532010)
文摘In this paper,the internal flow field in a centrifugal pump working at the design flow rate operating condition has been measured using the particle image velocimetry(PIV)technique with the fluorescent particles and the index-matched fluid technology.The index-marching fluid with the same refractive index as the transparent material has been prepared and applied in the present test of pump with geometrical complex walls.The comparison between velocity distributions of PIV results both with and without fluorescent particles,as well as with and without index-marching fluid are conducted to find the differences.The DES(Detached Eddy Simulation)has been employed to calculate the three-dimensional unsteady turbulent flow in the pump to examine and to certify the PIV measurement results.The DES results of instantaneous flow velocity fields agree with PIV test results with fluorescent particles and index-marching fluid.It is necessary to perform the PIV measurement of pumps with fluorescent seeds and index-marching fluid in order to get exact results.The experimental results show the distributions of velocity,steamlines,and the principal Reynolds normal stress(PRNS)and the principal Reynolds shear stress(PRSS).
基金Supported by The key project Grant from the Science and Technology Department of Zhejiang Province,China,No.2011C13036-2
文摘AIM: To compare shortand long-term outcomes of laparoscopy-assisted and open distal gastrectomy for gastric cancer. METHODS: A retrospective study was performed by comparing the outcomes of 54 patients who underwent laparoscopy-assisted distal gastrectomy (LADG) with those of 54 patients who underwent open distal gastrectomy (ODG) between October 2004 and October 2007. The patients' demographic data (age and gender), date of surgery, extent of lymphadenectomy, and differentiation and tumor-node-metastasis stage of the tumor were examined. The operative time, intraoperative blood loss, postoperative recovery, complications, pathological findings, and follow-up data were compared between the two groups.RESULTS: The mean operative time was significantly longer in the LADG group than in the ODG group (259.3 ± 46.2 min vs 199.8 ± 40.85 min; P < 0.05), whereas intraoperative blood loss and postoperative complications were significantly lower (160.2 ± 85.9 mL vs 257.8 ± 151.0 mL; 13.0% vs 24.1%, respectively, P < 0.05). In addition, the time to first flatus, time to initiate oral intake, and postoperative hospital stay were significantly shorter in the LADG group than in the ODG group (3.9 ± 1.4 d vs 4.4 ± 1.5 d; 4.6 ± 1.2 d vs 5.6 ± 2.1 d; and 9.5 ± 2.7 d vs 11.1 ± 4.1 d, respectively; P < 0.05). There was no significant difference between the LADG group and ODG group with regard to the number of harvested lymph nodes. The median followup was 60 mo (range, 5-97 mo). The 1-, 3-, and 5-year disease-free survival rates were 94.3%, 90.2%, and 76.7%, respectively, in the LADG group and 89.5%, 84.7%, and 82.3%, respectively, in the ODG group. The 1-, 3-, and 5-year overall survival rates were 98.0%, 91.9%, and 81.1%, respectively, in the LADG group and 91.5%, 86.9%, and 82.1%, respectively, in the ODG group. There was no significant difference between the two groups with regard to the survival rate. CONCLUSION: LADG is suitable and minimally invasive for treating distal gastric cancer and can achieve similar long-t
基金supported in part by the National Basic Research Program of China(973 Program)under Grant 2013CB336600the Beijing Natural Science Foundation under Grant 4131003+1 种基金the National Natural Science Foundation of China under Grant{61201187,61422109}the Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions under Grant YETP0110
文摘In this paper,we investigate the matched filter based spectrum sensing in a more reasonable cognitive radio(CR) scenario when the primary user(PU) has more than one transmit power levels,as regulated in most standards,i.e.,IEEE 802.11 Series,GSM,LTE,LTE-A,etc.This new multiple primary transmit power(MPTP) scenario is specialized by two different targets:detecting the presence of PU and identifying the power level.Compared to the traditional binary sensing where only the presence of PU is checked,SU may attain more information about the primary network(making CR more "intelligent") and design the subsequent optimization strategy.The key technology is the multiple hypothesis testing as opposed to the traditional binary hypothesis testing.We discuss two situations under whether the channel phase is known or not,and we derive the closed form solutions for decision regions and several performance metrics,from which some interesting phenomenons are observed and the related discussions are presented.Numerical examples are provided to corroborate the proposed studies.
文摘Background Little is known about the feasibility and safety of laparoscopy-assisted total gastrectomy （LATG） with extended lymphadenectomy in patients with advanced gastric cancer （AGC）.This study compared the technical feasibility,safety,and oncologic efficacy of LATG with open total gastrectomy （OTG） for AGC without serosa invasion.Methods From January 2009 to December 2011,235 patients underwent LATG and 153 patients underwent OTG for AGC without serosa invasion.Age,gender,and depth of invasion （pT2 and pT3） were matched by propensity scoring,and 116 patients （58 LATG and 58 OTG） were selected for analysis.Their clinicopathologic characteristics,postoperative outcomes,and survival were compared.Results There was no significant difference in clinicopathologic characteristics between the two propensity-matched groups.Median number of lymph nodes per patient was 29,and the mean number of retrieved lymph nodes was similar in the LATG and OTG groups （30.8±10.2 vs.29.0±8.3）.Peri-operative characteristics,operation time,number of transfused units per patient,and time to resumption of activities were similar in the two groups; while blood loss,times to first flatus and resumption of soft diet,and post-operative stay were significantly lower in the LATG group （P ＜0.05,respectively）.Rates of post-operative complications （12.1％ vs.15.5％） and postoperative mortality （0％ vs.1.7％）,as well as cumulative survival rates,were similar.Conclusions LATG with D2 lymphadenectomy is a safe and feasible procedure for AGC patients without serosa invasion.ProsPective.multicenter,randomized trials are needed to confirm the efficacy of LATG in this patient population.
文摘In order to compare the effect between haploidentical(HID) stem cell transplantation(HSCT) and matched sibling donor(MSD)stem cell transplantation for high-risk acute myeloid leukemia(AML) in first complete remission status(CR1), we retrospectively studied 170 cases who received stem cell transplantation from Jan 2008 to Jul 2015 in Peking University People's Hospital. We divided all cases into MSD group(43 cases) and HID(127 cases) group. Patients in HID and MSD group displayed similar baseline characteristics except for age distribution. There were no statistic differences for overall survival(OS), cumulative incidence of relapse, leukemia free survival(LFS), transplantation related mortality(TRM) between HID and MSD group. The 3-year OS, LFS for all patients was 63.9% and 59.7% respectively. Multivariate analysis showed that grade III-IV acute graft versus host disease(aGVHD) was an independent risk factor for treatment related mortality(HR=8.134, 95% CI:3.210–20.611, P<0.001), monosomy/complex chromosomal karyotype and white blood cell count more than 50×109 L-1 were two independent factors for relapse(HR=1.533, 95% CI: 1.040–2.260, P=0.031)(HR=1.004, 95% CI: 1.001–1.008, P=0.015).Grade III-IV aGVHD was an independent factor for mortality(HR=3.184, 95% CI: 1.718–5.902, P<0.001). These results demonstrated some risk factors for high-risk AML leukemia transplantation and indicated for AML patients in CR1 status, haplo stem cell transplantation could have the same therapeutic effect as MSD transplantation.
基金supported jointly by National Key R&D Program of China(No.2018YFC1503400)National Natural Science Foundation of China projects(Nos.41774067,U2039204,and 42074046)+2 种基金Science for Earthquake Resilience(No.XH20082Y)US National Science Foundation(No.1941719)University of California at Riverside.
文摘We present a high-resolution seismic catalog for the 2021 M_(S)6.4/M_(W)6.1 Yangbi sequence.The catalog has a time range of 2021-05-01 to 2021-05-28,and contains~8,000 well located events.It captures the features of the whole foreshock sequence and the early aftershocks.We designed a detection strategy incorporating both an artificial intelligent(AI)picker and a matched filter algorithm.Here,we adopt a hybrid AI method incorporating convolutional and recurrent neural network(CNN&RNN)for event detection and phase picking respectively(i.e.CERP),a light-weight AI picker that can be trained with small volume of data.CERP is first trained with detections from a STA/LTA and Kurtosis-based method called PAL,and then construct a rather complete template set of~4,000 events.Finally,the matched filter algorithm MESS augments the initial detections and measures differential travel times with cross-correlation,which finally results in precise relocation.This process gives 9,026 detections,among which 7,943 events can be well relocated.The catalog shows as expected power-law distribution of frequency magnitude and reveals detailed pattern of seismicity evolution.The main features are:(1)the foreshock sequence images simple fault geometry with consistent strike,but also show a variable event depth along strike;(2)the mainshock ruptures the same fault of the foreshock sequence and activate conjugate faults further to the southeast;(3)complex seismicity are developed in the post-seismic period,indicating complex triggering mechanisms.Thus,our catalog provides a reliable basis for further investigations,such as b-value studies,rupture process,and triggering relations.
基金supported by grants from National Natural Science Foundation of China(No.81473492 and No.81273907)Health Department of Hubei Province,China(No.2012Z-Z01)
文摘Wnt signaling plays an important role in the bone development and remodeling. The Wnt antagonist Dkk-1 is a potent inhibitor of bone formation. The aims of this study were firstly to compare the serum Dkk-1 levels in postmenopausal osteoporosis patients with age-matched healthy controls, and secondly, to assess the possible relationship between Dkk-1 and β-catenin, sclerostin, or bone turnover markers [CTX, PINP, N-MID-OT and 25（OH）D] in the setting of postmenopausal osteoporosis. A total of 350 patients with postmenopausal osteoporosis and 150 age-matched healthy controls were enrolled, and the serum levels of Dkk-1, β-catenin, sclerostin, OPG, and RANKL were detected by ELISA, and bone turnover markers [CTX, PINP, N-MID-OT and 25（OH）D] were measured by Roche electrochemiluminescence system in two groups. Serum Dkk-1 levels were significantly higher in postmenopausal osteoporosis group than in control group（P〈0.001）. Univariate analyses revealed that serum Dkk-1 levels were weakly negatively correlated to β-catenin（r=–0.161, P=0.003） and OPG（r=–0.106, P=0.047）, while multiple regression analysis showed a negative correlation between serum Dkk-1 levels with β-catenin（β=–0.165, P=0.009） and BMD（β=–0.139, P=0.027）, and a positive correlation between serum Dkk-1 levels and CTX（β=0.122, P=0.040） in postmenopausal osteoporosis group. No similar correlations ware observed in control group. The results provided evidence for the role of Dkk-1 in bone metabolism and demonstrated the link of Dkk-1 and Wnt/β-catenin in some ways.
文摘Multi-angle synthetic aperture radar（SAR） image matching is very challenging, because the same object may cause different backscattering patterns, heavily depending on the radar incident angle. A technique based on the relations between the invariant positions of ground targets among the reference and sensed images is proposed to accommodate the nonmatching patterns. It involves a target extraction using wavelet coefficient fusion, as well as a geometric voting matching routine for searching the matched control points（CPs） in the reference and sensed images, respectively. To accelerate the speed of the search, a robust, rapidly corresponding CPs determination strategy is exploited by utilizing the global spatial transformation model, as well as a procedure of outlier removal to ensure the desired accuracy. Meanwhile, the positions of the matched point pairs are relocated using mutual information. The final warping of the images according to the CPs is performed by using a polynomial function. The results show the possibility of matching multi-angle SAR images in general cases.
基金supported by the National Natural Science Foundation of China(11434012,41561144006,10974218,11174312)the Key Laboratory of Marine Surveying and Charting in Universities of Shandong(Shandong University of Science and Technology)(2013A02)+3 种基金the Scientific Research Foundation of Shandong University of Science and Technology for Recruited Talents under Grant(2014RCJJ004)the Project of the Public Science and Technology Research Funds Projects of Ocean(201305034)the National Key Technology R&D Program(2012BAB16B01)State Key Laboratory of Acoustics,Chinese Academy of Sciences(SKLA201407)
文摘In order to improve the ability to localize a source in an uncertain acoustic environment,a Bayesian approach,referred to here as Bayesian localization is used by including the environment in the parameter search space.Genetic algorithms are used for the parameter optimization.This method integrates the a posterior probability density（PPD） over environmental parameters to obtain a sequence of marginal probability distributions over source range and depth,from which the most-probable source location and localization uncertainties can be extracted.Considering that the seabed density and attenuation are less sensitive to the objective function of matched field processing,we utilize the empirical relationship to invert those parameters indirectly.The broadband signals recorded by a vertical line array in a Yellow Sea experiment in 2000 are processed and analyzed.It was found that,the Bayesian localization method that incorporates the environmental variability into the processor,made it robust to the uncertainty in the ocean environment.In addition,using the empirical relationship could enhance the localization accuracy.
文摘We study an finite-difference time-domain (FDTD) system of uniaxial perfectly matched layer (UPML) method for electromagnetic scattering problems. Particularly we analyze the discrete initial-boundary value problems of the transverse magnetic mode (TM) to Maxwell's equations with Yee's algorithm. An exterior domain in two spacial dimension is truncated by a square with a perfectly matched layer filled by a certain artificial medium. Besides, an artificial boundary condition is imposed on the outer boundary of the UPML. Using energy method, we obtain the stability of this FDTD system on the truncated domain. Numerical experiments are designed to approve the theoretical analysis.
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(2018R1D1A1B07040282 to JJ)+1 种基金a grant from Kyung Hee University in 2018(KHU-20181065 to JJ)
文摘A Schwann cell has regenerative capabilities and is an important cell in the peripheral nervous system.This microarray study is part of a bioinformatics study that focuses mainly on Schwann cells. Microarray data provide information on differences between microarray-based and experiment-based gene expression analyses. According to microarray data, several genes exhibit increased expression(fold change) but they are weakly expressed in experimental studies(based on morphology, protein and mRNA levels). In contrast, some genes are weakly expressed in microarray data and highly expressed in experimental studies;such genes may represent future target genes in Schwann cell studies. These studies allow us to learn about additional genes that could be used to achieve targeted results from experimental studies. In the current big data study by retrieving more than 5000 scientific articles from PubMed or NCBI, Google Scholar, and Google, 1016(up-and downregulated) genes were determined to be related to Schwann cells. However,no experiment was performed in the laboratory; rather, the present study is part of a big data analysis. Our study will contribute to our understanding of Schwann cell biology by aiding in the identification of genes.Based on a comparative analysis of all microarray data, we conclude that the microarray could be a good tool for predicting the expression and intensity of different genes of interest in actual experiments.
基金supported by the National Natural Science Foundation of China(61172138)the Natural Science Basic Research Plan in Shaanxi Province of China(2013JQ8040)+1 种基金the Fundamental Research Funds for the Central Universities(K5051302015K5051302040)
文摘For global navigation satellite system （GNSS） signals in Gaussian and Rayleigh fading channel, a novel signal detection algorithm is proposed. Under the low frequency uncertainty case, after performing discrete cosine transform （DCT） to the outputs of the partial matched filter （PMF） for every antenna, the high order com- ponents in the transforming domain will be filtered, then the equalgain （EG） combination for the inverse discrete cosine transform （IDCT） reconstructed signal would be done subsequently. Thus, due to the different frequency distribution characteristics between the noise and signals, after EG combination, the energy of signals has almost no loss and the noise energy is greatly reduced. The theoretical analysis and simulation results show that the detection algorithm can effectively improve the signal-to-noise ratio of the captured signal and increase the probability of detection under the same false alarm probability. In addition, it should be pointed out that this method can also be applied to Rayleigh fading channels with moving antenna.
基金Project supported by the National Natural Science Foundation of China (Grant No 60571058)the Specialized Research Fund for the Doctoral Program of Higher Education,China (Grant No 20070701010)
文摘Composite electromagnetic scattering from a two-dimensional （2D） ship-like target on a one-dimensional sea surface is investigated by using the finite-difference time-domain （FDTD） method. A uniaxial perfectly matched layer is adopted for truncation of FDTD lattices.The FDTD updated equations can be used for the total computation domain by choosing the uniaxial parameters properly. To validate the proposed numerical technique,a 2D infinitely long cylinder over the sea surface is taken into account first.The variation of angular distribution of the scattering changing with incident angle is calculated. The results show good agreement with the conventional moment method. Finally,the influence of the incident angle,the polarization,and the size of the ship-like target on the composite scattering coefficient is discussed in detail.
文摘AIM: To present the radiological results of total knee arthroplasty(TKA) with use of patient specific matched guides(PSG) from different manufacturer in patients suffering from severe osteoarthritis of the knee joint.METHODS: This study describes the results of 57 knees operated with 4 different PSG systems and a group operated with conventional instrumentation(n = 60) by a single surgeon. The PSG systems were compared with each other and subdivided into cut- and pin PSG. The biomechanical axis [hip-knee-ankle angle(HKA)], varus/valgus of the femur [frontal femoral component(FFC)] and tibia(frontal tibial component) component, flexion/extension of the femur [flexion/extension of the femur component(LFC)] and posterior slope of the tibia [lateral tibial component(LTC)] component were evaluated on long-leg standing and lateral X-rays. A percentage of > 3° deviation was seen as an outlier. RESULTS: The inter class correlation coefficient(ICC) revealed that radiographic measurements between both assessors were reliable(ICC > 0.8). Fisher exact test was used to test differences of proportions. The percentage of outliers of the HKA-axis was comparable between both the PSG and conventional groups(12.28% vs 18.33%, P < 0.424) and the cut- and pin PSG groups(14.3% vs 10.3%, P < 1.00). The percentage of outliers of the FFC(0% vs 18.33%, P < 0.000), LFC(15.78% vs 58.33%, P < 0.000) and LTC(15.78% vs 41.67%, P < 0.033) were significant different in favour of the PSGgroup. There were no significant differences regarding the outliers between the individual PSG systems and the PSG group subdivided into cut- and pin PSG.CONCLUSION: PSG for TKA show significant less outliers compared to the conventional technique. These single surgeon results suggest that PSG are ready for primetime.
