A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy（BNCT） was designed to evaluate whether the world＇s first in-hospital neutron irradiator（IHNI） was qualified for BNCT. ...A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy（BNCT） was designed to evaluate whether the world＇s first in-hospital neutron irradiator（IHNI） was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography（PET/CT） scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals.展开更多
Background Malignant sinonasal melanoma （MSM） is a rare tumor with a perplexing signal intensity due to variable histopathologic components. This study was undertaken to delineate its MR imaging features. Methods MR...Background Malignant sinonasal melanoma （MSM） is a rare tumor with a perplexing signal intensity due to variable histopathologic components. This study was undertaken to delineate its MR imaging features. Methods MR imaging findings of 10 patients （6 women and 4 men, mean age 61.3 years old） with pathologically confirmed MSM were retrospectively reviewed. The location, size, signal intensity, enhancement, and internal imaging characteristics of all tumors were evaluated. Signal intensity and degree of enhancement was graded in comparison with the gray matter and adjacent muscle uptake, respectively. Results There were 8 tumors that were pathologically confirmed to contain melanin. Compared to gray matter of the brain, 7 of them demonstrated hyperintensity on T1WI and 6 （6/7） showed hypointensity on T2Wl. There was multiple linear, dark-signal intensity on T2Wl within the mass in 9 of the 10 patients＇ tumors. Evaluated with gadolinium-enhanced imaging, all 10 patients showed moderate enhancement within the areas that were isointense in the lesion on pregadolinium TlWl. Moreover, some parts which displayed hyperintensity on TlWl within the tumors of 7 patients showed mild enhancement that was similar to muscle on a time-intensity curve （TIC）. Conclusions MSM shows characteristic MR signal intensity （hyperintensity on TlWl and the linear, low-signal intensity on T2Wl）, which may provide valuable information for clinical diagnosis. Together with conventional MRI, TIC may be useful for indicating pleomorphic patterns of MSM.展开更多
Background Choroidal melanoma is the most common intraocular malignant tumor in adults. It threatens not only the visual function but also the patient＇s life. Therefore, it is important to find a non-traumatic, quant...Background Choroidal melanoma is the most common intraocular malignant tumor in adults. It threatens not only the visual function but also the patient＇s life. Therefore, it is important to find a non-traumatic, quantitative and repetitive diagnostic method. This study investigated the value of quantitative analysis of contrast-enhanced ultrasound （CEUS） in the diagnosis of choroidal melanoma. Methods CEUS were performed in 51 cases of choroidal melanoma, which were diagnosed either pathologically or clinically and in 14 cases of choroidal hemangioma. The characteristics of the time-intensity curve of the contrast agent were analyzed. For the quantitative analysis, the following parameters of the contrast agent in the lesion were included： rising time （RT）, time to peak （TTP）, maximum intensity （MI） and the mean transit time （MTT）. Results Choroidal melanoma had the following characteristics on CEUS： Choroidal lesions were completely filled with contrast agent. The typical filling pattern was centripetal, with the peripheral of the choroidal lesion filled with the contrast agent first and then the center of the lesion. In some cases, areas with contrast agent filling defect were obseved in the lesions. The contrast agent filled the lesion slower than the normal eye and orbital tissue but faded faster in the lesion. Quantitative analysis showed that in choroidal melanoma, MI of contrast agent （191.31%±146.90%） was significantly more than that of the normal tissue （100.00%±0.00%） （P 〈0.05） and MTT （（63.56±26.04） seconds） was significanly less than that of the normal tissue （（149.87±182.68）seconds） （P 〈0.05）. TTP （22.80±9.85） was less than that of the normal tissue （（29.57±24.76） seconds） and RT （（18.52±7.09） seconds） was less than that of the normal tissue （（26.45±21.83） seconds）. Both the differences of TTP and RT were not statistically significant though. Logistic regression showed that to predict choroidal melanoma a展开更多
基金supported by the National Science&Technology Pillar Program during the 12th Five-Year Plan Period(No.2013BAI01B08)the Major Program of the National Natural Science Foundation of China(No.51290295)
文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy（BNCT） was designed to evaluate whether the world＇s first in-hospital neutron irradiator（IHNI） was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography（PET/CT） scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals.
基金This study was tSnancally supported by the China Postdoctoral Science Foundation （No. 20090461433）, and the National Natural Science Foundation of China （No. 30900352）.
文摘Background Malignant sinonasal melanoma （MSM） is a rare tumor with a perplexing signal intensity due to variable histopathologic components. This study was undertaken to delineate its MR imaging features. Methods MR imaging findings of 10 patients （6 women and 4 men, mean age 61.3 years old） with pathologically confirmed MSM were retrospectively reviewed. The location, size, signal intensity, enhancement, and internal imaging characteristics of all tumors were evaluated. Signal intensity and degree of enhancement was graded in comparison with the gray matter and adjacent muscle uptake, respectively. Results There were 8 tumors that were pathologically confirmed to contain melanin. Compared to gray matter of the brain, 7 of them demonstrated hyperintensity on T1WI and 6 （6/7） showed hypointensity on T2Wl. There was multiple linear, dark-signal intensity on T2Wl within the mass in 9 of the 10 patients＇ tumors. Evaluated with gadolinium-enhanced imaging, all 10 patients showed moderate enhancement within the areas that were isointense in the lesion on pregadolinium TlWl. Moreover, some parts which displayed hyperintensity on TlWl within the tumors of 7 patients showed mild enhancement that was similar to muscle on a time-intensity curve （TIC）. Conclusions MSM shows characteristic MR signal intensity （hyperintensity on TlWl and the linear, low-signal intensity on T2Wl）, which may provide valuable information for clinical diagnosis. Together with conventional MRI, TIC may be useful for indicating pleomorphic patterns of MSM.
文摘Background Choroidal melanoma is the most common intraocular malignant tumor in adults. It threatens not only the visual function but also the patient＇s life. Therefore, it is important to find a non-traumatic, quantitative and repetitive diagnostic method. This study investigated the value of quantitative analysis of contrast-enhanced ultrasound （CEUS） in the diagnosis of choroidal melanoma. Methods CEUS were performed in 51 cases of choroidal melanoma, which were diagnosed either pathologically or clinically and in 14 cases of choroidal hemangioma. The characteristics of the time-intensity curve of the contrast agent were analyzed. For the quantitative analysis, the following parameters of the contrast agent in the lesion were included： rising time （RT）, time to peak （TTP）, maximum intensity （MI） and the mean transit time （MTT）. Results Choroidal melanoma had the following characteristics on CEUS： Choroidal lesions were completely filled with contrast agent. The typical filling pattern was centripetal, with the peripheral of the choroidal lesion filled with the contrast agent first and then the center of the lesion. In some cases, areas with contrast agent filling defect were obseved in the lesions. The contrast agent filled the lesion slower than the normal eye and orbital tissue but faded faster in the lesion. Quantitative analysis showed that in choroidal melanoma, MI of contrast agent （191.31%±146.90%） was significantly more than that of the normal tissue （100.00%±0.00%） （P 〈0.05） and MTT （（63.56±26.04） seconds） was significanly less than that of the normal tissue （（149.87±182.68）seconds） （P 〈0.05）. TTP （22.80±9.85） was less than that of the normal tissue （（29.57±24.76） seconds） and RT （（18.52±7.09） seconds） was less than that of the normal tissue （（26.45±21.83） seconds）. Both the differences of TTP and RT were not statistically significant though. Logistic regression showed that to predict choroidal melanoma a
