Oxo-1, 15-pentadecanlactam 7 was synthesized from cyclododecanone with a total yield of 36% in a seven-step reaction. The azide 5 to 12-nitro-1, 15-pentadecanlactam 6 is the key step featured by direct ring expansion.
Using 2-bromo-1-methylpyridimium iodide as carboxyl activating agent, 10 ansa-macrolactams were prepared conveniently from the corresponding seco-precursor w-aminoacids in the yields of 78-2%.
文摘Oxo-1, 15-pentadecanlactam 7 was synthesized from cyclododecanone with a total yield of 36% in a seven-step reaction. The azide 5 to 12-nitro-1, 15-pentadecanlactam 6 is the key step featured by direct ring expansion.
基金Project supported by the National Natural Science Foundation of China.
文摘 Using 2-bromo-1-methylpyridimium iodide as carboxyl activating agent, 10 ansa-macrolactams were prepared conveniently from the corresponding seco-precursor w-aminoacids in the yields of 78-2%.
