The title compound,sarcophytol-A benzyl ether has been synthesized through 13 steps by employing acetone and geraniol as starting materials.The key steps in the synthesis were double bond migration reaction of allylic...The title compound,sarcophytol-A benzyl ether has been synthesized through 13 steps by employing acetone and geraniol as starting materials.The key steps in the synthesis were double bond migration reaction of allylic alcohols 5 and 6,phase transfer catalytic coupling (PTC)reaction of Ⅱ with 7 and the cyclization reaction of dicarbonyl acyclic precursor induced by TiCl_3-AlCl_3(3:1)/Zn-Cu system.展开更多
基金This project was supported by the National Natural Science Foundation of China Special Research Grant for Doctoral Sites in Universities.
文摘The title compound,sarcophytol-A benzyl ether has been synthesized through 13 steps by employing acetone and geraniol as starting materials.The key steps in the synthesis were double bond migration reaction of allylic alcohols 5 and 6,phase transfer catalytic coupling (PTC)reaction of Ⅱ with 7 and the cyclization reaction of dicarbonyl acyclic precursor induced by TiCl_3-AlCl_3(3:1)/Zn-Cu system.