Due to the increasing burden on healthcare budgets of musculoskeletal system disease and injury, there is a growing need for safe, effective and simple therapies. Conditions such as osteoporosis severely impact onqual...Due to the increasing burden on healthcare budgets of musculoskeletal system disease and injury, there is a growing need for safe, effective and simple therapies. Conditions such as osteoporosis severely impact onquality of life and result in hundreds of hours of hospital time and resources. There is growing interest in the use of low magnitude, high frequency vibration(LMHFV) to improve bone structure and muscle performance in a variety of different patient groups. The technique has shown promise in a number of different diseases, but is poorly understood in terms of the mechanism of action. Scientific papers concerning both the in vivo and in vitro use of LMHFV are growing fast, but they cover a wide range of study types, outcomes measured and regimens tested. This paper aims to provide an overview of some effects of LMHFV found during in vivo studies. Furthermore we will review research concerning the effects of vibration on the cellular responses, in particular for cells within the musculoskeletal system. This includes both osteogenesis and adipogenesis, as well as the interaction between MSCs and other cell types within bone tissue.展开更多
Low-magnitude, high-frequency vibration(LMHFV) with rest days(particularly seven rest days) was considerably effective in improving the morphological and mechanical properties of rat proximal femur. However, current k...Low-magnitude, high-frequency vibration(LMHFV) with rest days(particularly seven rest days) was considerably effective in improving the morphological and mechanical properties of rat proximal femur. However, current knowledge is limited regarding the possible benefit of this mechanical regimen to other bone sites and whether the optimal rest days are the same. This study followed our previous experiment on LMHFV loading with rest days for three-month-old male Wistar rats. The experiment involved seven groups, namely, vibrational loading for X day followed with X day rest(X=1, 3, 5, 7), daily vibrational loading,tail suspension and baseline control. Micro-computed tomography(micro-CT) scanning was used to evaluate the microarchitecture of the distal femoral trabecular bone. Micro-CT image-based microfinite element analysis was performed for each distal femoral metaphysis. LMHFV with rest days substantially changed the trabecular arrangement from remarkably plate-like to rod-like. Vibrational loading with 1 day rest was substantially effective in improving the architecture and apparent-and tissuelevel mechanical properties of the rat distal femoral metaphysis. This study may provide an improved understanding of the sitespecific responses of bone tissue to LMHFV with rest days for a substantially effective therapy of a targeted bone site.展开更多
Applicability of regional P/S amplitude ratios for the discrimination of low-magnitude seismic events was tested and proved using earthquakes and explosions in Central Asia. Results obtained show that regional P/S amp...Applicability of regional P/S amplitude ratios for the discrimination of low-magnitude seismic events was tested and proved using earthquakes and explosions in Central Asia. Results obtained show that regional P/S amplitude ratios which may discriminate medium or large magnitude events well, are also applicable to low magnitude events Their performances for low magnitude events are almost as good as that for medium or large events. Statistical comparisons based on 25 P/S discriminate from the four seismic stations WMQ, BLK, MUL and MAK showed that the average misclassification rate for low-magnitude seismic events averagely was only 2 percent higher than that for medium and large magnitude seismic events.展开更多
以信息节点的幅度和作为校验方程的可靠度信息,提出两种简单高效的低密度奇偶效验(low density parity check,LDPC)码的加权比特翻转(weighted bit flipping,WBF)译码算法。仿真结果表明,在加性高斯白噪声信道下,误比特率为10-5时,相比...以信息节点的幅度和作为校验方程的可靠度信息,提出两种简单高效的低密度奇偶效验(low density parity check,LDPC)码的加权比特翻转(weighted bit flipping,WBF)译码算法。仿真结果表明,在加性高斯白噪声信道下,误比特率为10-5时,相比于传统的WBF和改进型WBF(modified WBF,MWBF)算法,提出的一种算法可分别获得约1.65dB和1.31dB的增益。同时,平均迭代次数也大大降低。展开更多
基金Engineering and Physical Sciences Research Council
文摘Due to the increasing burden on healthcare budgets of musculoskeletal system disease and injury, there is a growing need for safe, effective and simple therapies. Conditions such as osteoporosis severely impact onquality of life and result in hundreds of hours of hospital time and resources. There is growing interest in the use of low magnitude, high frequency vibration(LMHFV) to improve bone structure and muscle performance in a variety of different patient groups. The technique has shown promise in a number of different diseases, but is poorly understood in terms of the mechanism of action. Scientific papers concerning both the in vivo and in vitro use of LMHFV are growing fast, but they cover a wide range of study types, outcomes measured and regimens tested. This paper aims to provide an overview of some effects of LMHFV found during in vivo studies. Furthermore we will review research concerning the effects of vibration on the cellular responses, in particular for cells within the musculoskeletal system. This includes both osteogenesis and adipogenesis, as well as the interaction between MSCs and other cell types within bone tissue.
基金supported by the National Natural Science Foundation of China (81471753, 11432016, 11322223)the Science and Technology Development Plan Projects of Jilin province (20160101297JC, 20170519008JH, 20170520093JH)
文摘Low-magnitude, high-frequency vibration(LMHFV) with rest days(particularly seven rest days) was considerably effective in improving the morphological and mechanical properties of rat proximal femur. However, current knowledge is limited regarding the possible benefit of this mechanical regimen to other bone sites and whether the optimal rest days are the same. This study followed our previous experiment on LMHFV loading with rest days for three-month-old male Wistar rats. The experiment involved seven groups, namely, vibrational loading for X day followed with X day rest(X=1, 3, 5, 7), daily vibrational loading,tail suspension and baseline control. Micro-computed tomography(micro-CT) scanning was used to evaluate the microarchitecture of the distal femoral trabecular bone. Micro-CT image-based microfinite element analysis was performed for each distal femoral metaphysis. LMHFV with rest days substantially changed the trabecular arrangement from remarkably plate-like to rod-like. Vibrational loading with 1 day rest was substantially effective in improving the architecture and apparent-and tissuelevel mechanical properties of the rat distal femoral metaphysis. This study may provide an improved understanding of the sitespecific responses of bone tissue to LMHFV with rest days for a substantially effective therapy of a targeted bone site.
基金Foundation of Verification Researches for Army Control Technology (513310101).
文摘Applicability of regional P/S amplitude ratios for the discrimination of low-magnitude seismic events was tested and proved using earthquakes and explosions in Central Asia. Results obtained show that regional P/S amplitude ratios which may discriminate medium or large magnitude events well, are also applicable to low magnitude events Their performances for low magnitude events are almost as good as that for medium or large events. Statistical comparisons based on 25 P/S discriminate from the four seismic stations WMQ, BLK, MUL and MAK showed that the average misclassification rate for low-magnitude seismic events averagely was only 2 percent higher than that for medium and large magnitude seismic events.
文摘以信息节点的幅度和作为校验方程的可靠度信息,提出两种简单高效的低密度奇偶效验(low density parity check,LDPC)码的加权比特翻转(weighted bit flipping,WBF)译码算法。仿真结果表明,在加性高斯白噪声信道下,误比特率为10-5时,相比于传统的WBF和改进型WBF(modified WBF,MWBF)算法,提出的一种算法可分别获得约1.65dB和1.31dB的增益。同时,平均迭代次数也大大降低。
