Objective:To observe the effects of long-snake moxibustion on the hypothalamic-pituitary-adrenocortical(HPA)axis and hepatic 11β-hydroxy steroid dehydrogenase type 1(11β-HSD1)expression in rats with kidney yang defi...Objective:To observe the effects of long-snake moxibustion on the hypothalamic-pituitary-adrenocortical(HPA)axis and hepatic 11β-hydroxy steroid dehydrogenase type 1(11β-HSD1)expression in rats with kidney yang deficiency to provide a basis for later in-depth exploration of the action mechanism of longsnakemoxibustion on suchrats.Methods:Fifteen SPF-grade,male,SD rats were randomly divided into a blank control group,a model group,and a long-snake moxibustion treatment group,with five rats in each group.Hydrocortisone powder(30 mg/kg)was administered by gavage at a volume of 10 mL/kg to prepare the rat model of kidney yang deficiency.After successful modeling,the rats in the long-snake moxibustion treatment group underwent long-snake moxibustion treatment every other day along the governor vessel from Dazhui(GV14)to Shenshu(BL23),for a period of 14 days.The remaining two groups were secured in the same way as the long-snake moxibustion treatment group,although they did not receive any treatment.The body weight,rectal temperature,and spontaneous activity count of the rats,as well as serum levels of corticotropin releasing hormone(CRH)and corticosterone(CORT)were detected by ELISA before modeling,after modeling,and after treatment.The amount of 11β-HSD1 protein in rat liver was determined by immunohistochemistry and Western blot analysis.Results:Compared with the rats in the blank control group,those in the model group exhibited a significant decrease in the trend of body weight growth and in rectal temperature(P<0.05),as well as a slight yet non-significant decrease in spontaneous activity count(P>0.05);compared with the rats in the model group,the rats in the treatment group exhibited a significant increase in rectal temperature(P<0.05)and in spontaneous activity count(P<0.05).Moreover,after 14 days of treatment,compared with the rats in the blank,the rats in the model group exhibited a significant decrease in serum cORT content(P<0.05)and in the expression of 11β-HSD1 in the liver(P<0.05),as well as a slight 展开更多
Vector bending sensing has been consistently growing in many fields.A low-cost and high sensitivity vector bending sensor based on a chirped long-period fiber grating[LPFG]with an off-axis micro helix taper is propose...Vector bending sensing has been consistently growing in many fields.A low-cost and high sensitivity vector bending sensor based on a chirped long-period fiber grating[LPFG]with an off-axis micro helix taper is proposed and experimentally demonstrated.The grating is composed of several sections of single-mode fiber with gradually larger lengths,and the off-axis micro helix tapers with fixed lengths when they are fabricated by using the arc discharge technology.The large refractive index modulation in the micro-helix taper greatly reduces the sensor size.The total length of the sensor is only 4.67 mm.The micro-helix taper-based LPFG can identify the bending direction due to the asymmetric structure introduced by the micro helix.The experimental results show that the transmission spectra of the sensor have distinct responses for different bending directions,and the maximum bending sensitivity is 14.08 nm/m^(-1)in the range from 0.128 m^(-1)to 1.28 m^(-1).The proposed bending sensor possesses pronounced advantages,such as high sensitivity,small size,low cost,and orientation identification,and offers a very promising method for bend measurement.展开更多
目的研究下切牙长轴(long axis of the lower incisors, IA)与颏轴(long axis of the mandibular symphysis, MA)在天然状态下的一致性情况,为正畸治疗中下切牙的健康定位提供参考。方法从头颅侧位片数据库中等量选取安氏Ⅰ、Ⅱ、Ⅲ类...目的研究下切牙长轴(long axis of the lower incisors, IA)与颏轴(long axis of the mandibular symphysis, MA)在天然状态下的一致性情况,为正畸治疗中下切牙的健康定位提供参考。方法从头颅侧位片数据库中等量选取安氏Ⅰ、Ⅱ、Ⅲ类治疗前患者共300例,定义四种颏轴,分别测量四种颏轴与下切牙长轴所成角度(angle between MA and IA,MIA)以及下中切牙角(incisor-mandibular plane angle, IMPA),按照不同水平向和垂直向骨面型分组进行方差分析。结果用于定义颏轴的标志点中,颊舌侧下齿槽缘点的中点Id-c和下颌联合中心点D,不同研究者定点的变异系数最小,可重复性最好。由Id-c和D构成的颏轴与下中切牙长轴所成角度MIA在安氏Ⅰ、Ⅱ、Ⅲ类的平均值分别为(9.45±4.06)°、(10.56±3.57)°、(4.35±3.71)°;在Ⅲ类高、均、低角分别为(2.89±0.87)°、(3.66±0.43)°、(5.84±0.71)°。既体现了下切牙牙轴在不同矢状向和垂直向骨面型的代偿倾向,又基本与颏轴保持一致,二者所成角度80%位于(2.18~13.87)°区间。结论天然状态下,下切牙长轴与颏轴方向基本一致,颏轴与下中切牙长轴所成角度MIA与下中切牙角IMPA相比,受不同水平向和垂直向骨面型变异的影响更小,更能代表符合生理要求的下切牙倾斜度。正畸治疗可以考虑以此为进行下切牙的合理定位,从而确保咬合力的健康传递。展开更多
Fatty acids are energy substrates and cell components which participate in regulating signal transduction,transcription factor activity and secretion of bioactive lipid mediators.The acyl-CoA synthetases(ACSs)family c...Fatty acids are energy substrates and cell components which participate in regulating signal transduction,transcription factor activity and secretion of bioactive lipid mediators.The acyl-CoA synthetases(ACSs)family containing 26 family members exhibits tissue-specific distribution,distinct fatty acid substrate preferences and diverse biological functions.Increasing evidence indicates that dysregulation of fatty acid metabolism in the liver-gut axis,designated as the bidirectional relationship between the gut,microbiome and liver,is closely associated with a range of human diseases including metabolic disorders,inflammatory disease and carcinoma in the gastrointestinal tract and liver.In this review,we depict the role of ACSs in fatty acid metabolism,possible molecular mechanisms through which they exert functions,and their involvement in hepatocellular and colorectal carcinoma,with particular attention paid to long-chain fatty acids and small-chain fatty acids.Additionally,the liver-gut communication and the liver and gut intersection with the microbiome as well as diseases related to microbiota imbalance in the liver-gut axis are addressed.Moreover,the development of potentially therapeutic small molecules,proteins and compounds targeting ACSs in cancer treatment is summarized.展开更多
基金Supported by National Natural Science Foundation of China:81960900。
文摘Objective:To observe the effects of long-snake moxibustion on the hypothalamic-pituitary-adrenocortical(HPA)axis and hepatic 11β-hydroxy steroid dehydrogenase type 1(11β-HSD1)expression in rats with kidney yang deficiency to provide a basis for later in-depth exploration of the action mechanism of longsnakemoxibustion on suchrats.Methods:Fifteen SPF-grade,male,SD rats were randomly divided into a blank control group,a model group,and a long-snake moxibustion treatment group,with five rats in each group.Hydrocortisone powder(30 mg/kg)was administered by gavage at a volume of 10 mL/kg to prepare the rat model of kidney yang deficiency.After successful modeling,the rats in the long-snake moxibustion treatment group underwent long-snake moxibustion treatment every other day along the governor vessel from Dazhui(GV14)to Shenshu(BL23),for a period of 14 days.The remaining two groups were secured in the same way as the long-snake moxibustion treatment group,although they did not receive any treatment.The body weight,rectal temperature,and spontaneous activity count of the rats,as well as serum levels of corticotropin releasing hormone(CRH)and corticosterone(CORT)were detected by ELISA before modeling,after modeling,and after treatment.The amount of 11β-HSD1 protein in rat liver was determined by immunohistochemistry and Western blot analysis.Results:Compared with the rats in the blank control group,those in the model group exhibited a significant decrease in the trend of body weight growth and in rectal temperature(P<0.05),as well as a slight yet non-significant decrease in spontaneous activity count(P>0.05);compared with the rats in the model group,the rats in the treatment group exhibited a significant increase in rectal temperature(P<0.05)and in spontaneous activity count(P<0.05).Moreover,after 14 days of treatment,compared with the rats in the blank,the rats in the model group exhibited a significant decrease in serum cORT content(P<0.05)and in the expression of 11β-HSD1 in the liver(P<0.05),as well as a slight
基金supported in part by the National Natural Science Foundation of China(NSFC)(Nos.62205087,62175049,and 62105077)Natural Science Foundation of Heilongjiang Province in China(No.YQ2021F002)+1 种基金Fundamental Research Funds for the Central Universities(Nos.3072022TS2501 and 3072021CFJ2504)China Postdoctoral Science Foundation(No.2022M710933)。
文摘Vector bending sensing has been consistently growing in many fields.A low-cost and high sensitivity vector bending sensor based on a chirped long-period fiber grating[LPFG]with an off-axis micro helix taper is proposed and experimentally demonstrated.The grating is composed of several sections of single-mode fiber with gradually larger lengths,and the off-axis micro helix tapers with fixed lengths when they are fabricated by using the arc discharge technology.The large refractive index modulation in the micro-helix taper greatly reduces the sensor size.The total length of the sensor is only 4.67 mm.The micro-helix taper-based LPFG can identify the bending direction due to the asymmetric structure introduced by the micro helix.The experimental results show that the transmission spectra of the sensor have distinct responses for different bending directions,and the maximum bending sensitivity is 14.08 nm/m^(-1)in the range from 0.128 m^(-1)to 1.28 m^(-1).The proposed bending sensor possesses pronounced advantages,such as high sensitivity,small size,low cost,and orientation identification,and offers a very promising method for bend measurement.
文摘目的研究下切牙长轴(long axis of the lower incisors, IA)与颏轴(long axis of the mandibular symphysis, MA)在天然状态下的一致性情况,为正畸治疗中下切牙的健康定位提供参考。方法从头颅侧位片数据库中等量选取安氏Ⅰ、Ⅱ、Ⅲ类治疗前患者共300例,定义四种颏轴,分别测量四种颏轴与下切牙长轴所成角度(angle between MA and IA,MIA)以及下中切牙角(incisor-mandibular plane angle, IMPA),按照不同水平向和垂直向骨面型分组进行方差分析。结果用于定义颏轴的标志点中,颊舌侧下齿槽缘点的中点Id-c和下颌联合中心点D,不同研究者定点的变异系数最小,可重复性最好。由Id-c和D构成的颏轴与下中切牙长轴所成角度MIA在安氏Ⅰ、Ⅱ、Ⅲ类的平均值分别为(9.45±4.06)°、(10.56±3.57)°、(4.35±3.71)°;在Ⅲ类高、均、低角分别为(2.89±0.87)°、(3.66±0.43)°、(5.84±0.71)°。既体现了下切牙牙轴在不同矢状向和垂直向骨面型的代偿倾向,又基本与颏轴保持一致,二者所成角度80%位于(2.18~13.87)°区间。结论天然状态下,下切牙长轴与颏轴方向基本一致,颏轴与下中切牙长轴所成角度MIA与下中切牙角IMPA相比,受不同水平向和垂直向骨面型变异的影响更小,更能代表符合生理要求的下切牙倾斜度。正畸治疗可以考虑以此为进行下切牙的合理定位,从而确保咬合力的健康传递。
基金Supported by the Interdisziplinäres Zentrum für Klinische Forschung(IZKF-MSP-06)of University Hospital Jena.
文摘Fatty acids are energy substrates and cell components which participate in regulating signal transduction,transcription factor activity and secretion of bioactive lipid mediators.The acyl-CoA synthetases(ACSs)family containing 26 family members exhibits tissue-specific distribution,distinct fatty acid substrate preferences and diverse biological functions.Increasing evidence indicates that dysregulation of fatty acid metabolism in the liver-gut axis,designated as the bidirectional relationship between the gut,microbiome and liver,is closely associated with a range of human diseases including metabolic disorders,inflammatory disease and carcinoma in the gastrointestinal tract and liver.In this review,we depict the role of ACSs in fatty acid metabolism,possible molecular mechanisms through which they exert functions,and their involvement in hepatocellular and colorectal carcinoma,with particular attention paid to long-chain fatty acids and small-chain fatty acids.Additionally,the liver-gut communication and the liver and gut intersection with the microbiome as well as diseases related to microbiota imbalance in the liver-gut axis are addressed.Moreover,the development of potentially therapeutic small molecules,proteins and compounds targeting ACSs in cancer treatment is summarized.
