目的观察圆窗局部灌注泊洛沙姆407对耳蜗功能和结构的影响。方法 16只健康豚鼠右耳圆窗灌注100μl 20%泊洛沙姆407溶液作为实验组,左耳灌注生理盐水作为对照组,另取4只动物不予处理作为阴性对照组。于灌注前、后及灌注后第7、14、28及49...目的观察圆窗局部灌注泊洛沙姆407对耳蜗功能和结构的影响。方法 16只健康豚鼠右耳圆窗灌注100μl 20%泊洛沙姆407溶液作为实验组,左耳灌注生理盐水作为对照组,另取4只动物不予处理作为阴性对照组。于灌注前、后及灌注后第7、14、28及49 d 行听性脑干诱发电位(auditory brainstem response,ABR)检测,并于检测后分别处死4只动物,行耳蜗基底膜铺片并计数。结果泊洛沙姆407灌注后 ABR 阈值较灌注前均有所提高,但在49 d 时恢复至灌注前水平;耳蜗毛细胞计数显示泊洛沙姆407圆窗灌注后无明显毛细胞缺失。结论泊洛沙姆407圆窗灌注对 ABR阈值有暂时性影响,但未对耳蜗功能和结构起到持久性不可逆性损伤,符合中、内耳疾病的缓释给药治疗的条件。展开更多
Background:Pre-operative assessment with high-resolution magnetic resonance imaging(MRI)is useful for assessing the risk of local recurrence(LR)and survival in rectal cancer.However,few studies have explored the clini...Background:Pre-operative assessment with high-resolution magnetic resonance imaging(MRI)is useful for assessing the risk of local recurrence(LR)and survival in rectal cancer.However,few studies have explored the clinical importance of the morphology of the anterior mesorectum,especially in patients with anterior cancer.Hence,the study aimed to investigate the impact of the morphology of the anterior mesorectum on LR in patients with primary rectal cancer.Methods:A retrospective study was performed on 176 patients who underwent neoadjuvant treatment and curative-intent surgery.Patients were divided into two groups according to the morphology of the anterior mesorectum on sagittal MRI:(1)linear type:the anterior mesorectum was thin and linear;and(2)triangular type:the anterior mesorectum was thick and had a unique triangular shape.Clinicopathological and LR data were compared between patients with linear type anterior mesorectal morphology and patients with triangular type anterior mesorectal morphology.Results:Morphometric analysis showed that 90(51.1%)patients had linear type anterior mesorectal morphology,while 86(48.9%)had triangular type anterior mesorectal morphology.Compared to triangular type anterior mesorectal morphology,linear type anterior mesorectal morphology was more common in females and was associated with a higher risk of circumferential resection margin involvement measured by MRI(35.6%[32/90]vs.16.3%[14/86],P=0.004)and a higher 5-year LR rate(12.2%vs.3.5%,P=0.030).In addition,the combination of linear type anterior mesorectal morphology and anterior tumors was confirmed as an independent risk factor for LR(odds ratio=4.283,P=0.014).Conclusions:The classification established in this study was a simple way to describe morphological characteristics of the anterior mesorectum.The combination of linear type anterior mesorectal morphology and anterior tumors was an independent risk factor for LR and may act as a tool to assist with LR risk stratification and treatment selection.展开更多
The semi-solid slurry of A356 alloy was prepared by low superheat pouring and slightly electromagnetic stirring, in which a pure copper rod was used to produce local chilling. The effect of chilling by the rod on morp...The semi-solid slurry of A356 alloy was prepared by low superheat pouring and slightly electromagnetic stirring, in which a pure copper rod was used to produce local chilling. The effect of chilling by the rod on morphology and size of primary α(Al) in A356 was researched. The results indicate that the chilling by the rod remarkably affects the morphology and the size of primary α(Al). Primary α(Al) with particle-like shape is distributed uniformly in A356, and there is no transient area in structure morphology. Compared with the samples prepared without the local chilling, the nucleation rate, morphology and grain size of primary α(Al) in A356 prepared by low superheat pouring and slightly electromagnetic stirring with the rod are markedly improved. Under the condition of chilling, the pouring temperature can be suitably raised to obtain primary α(Al) with particle-like shape.展开更多
1 Introduction C<sub>60</sub> crystal is a new form of pure, solid carbon and has been widely investigated. But until now, there still exists the ambiguity in its crystal structure. Early paper showed that...1 Introduction C<sub>60</sub> crystal is a new form of pure, solid carbon and has been widely investigated. But until now, there still exists the ambiguity in its crystal structure. Early paper showed that C<sub>60</sub> molecules stack in a hexagonal close-packed （hcp） lattice with α=10.02A, c=16.36A, but other ones reported that C<sub>60</sub> crystal has a face-centred-cubic （foe） lattice with α=14.172,. Foc and hcp structures are both stable at room temperature, whereas from the energetic point of view, fcc structure is much stabler. Moreover, the differences in the展开更多
Objective: To propose a method to segment tongue- images efficiently, and extract tongue- body accurately and quickly. Methods: Firstly, a kind of color- images' pre- processing technique was used to solve tongue-...Objective: To propose a method to segment tongue- images efficiently, and extract tongue- body accurately and quickly. Methods: Firstly, a kind of color- images' pre- processing technique was used to solve tongue- surface reflection problem. Neighbouring and similar region's information was used to restore the region with tongue- surface reflection problem by replacement. Secondly, the restored image was transformed into a gray one, and then processed by mathematical morphological operation- dilation to get a closed- loop edge. The third technique used was watershed algorithm, which is an usual tool in image segmentation. 'Watershed' function of matlab software was used to complete this algorithm. After that, region- combination technique was used. Through measuring neighbourship and similarity of regions, a non- objective and non- background region was merged into one of its neighbouring regions. This step was repeated until only two regions, objective and background regions, were left in the image. At last, corresponding to the merged image, tongue- body image was got from the original image. Results: 316 images were randomly taken from the image library for experiments, and 299 images were correctly segmented, so, the successful ratio is 94.62%. On the other hand, average time of running this method was about 50 s under whole sampling environment. Conclusion: The method presented in this paper can segment a tongue- body image from its original one effectively, and thus laying a good foundation for the following analysis work.展开更多
文摘目的观察圆窗局部灌注泊洛沙姆407对耳蜗功能和结构的影响。方法 16只健康豚鼠右耳圆窗灌注100μl 20%泊洛沙姆407溶液作为实验组,左耳灌注生理盐水作为对照组,另取4只动物不予处理作为阴性对照组。于灌注前、后及灌注后第7、14、28及49 d 行听性脑干诱发电位(auditory brainstem response,ABR)检测,并于检测后分别处死4只动物,行耳蜗基底膜铺片并计数。结果泊洛沙姆407灌注后 ABR 阈值较灌注前均有所提高,但在49 d 时恢复至灌注前水平;耳蜗毛细胞计数显示泊洛沙姆407圆窗灌注后无明显毛细胞缺失。结论泊洛沙姆407圆窗灌注对 ABR阈值有暂时性影响,但未对耳蜗功能和结构起到持久性不可逆性损伤,符合中、内耳疾病的缓释给药治疗的条件。
基金National Clinical Key Specialty Construction Project (General Surgery) of China(No. 2012-649)National Natural Science Foundation of China(No. 81902378)+4 种基金Joint Funds for the innovation of Science and Technology, Fujian province(No. 2020Y9071)Medical Science Research Foundation of Beijing Medical and Health Foundation(No. B20062DS)Bethune Charitable Foundation(No. X-J2018-004)Fujian provincial health technology project(Nos. 2020CXA025, 2021GGA013)Natural Science Foundation of Fujian Province(No. 2020J011030)
文摘Background:Pre-operative assessment with high-resolution magnetic resonance imaging(MRI)is useful for assessing the risk of local recurrence(LR)and survival in rectal cancer.However,few studies have explored the clinical importance of the morphology of the anterior mesorectum,especially in patients with anterior cancer.Hence,the study aimed to investigate the impact of the morphology of the anterior mesorectum on LR in patients with primary rectal cancer.Methods:A retrospective study was performed on 176 patients who underwent neoadjuvant treatment and curative-intent surgery.Patients were divided into two groups according to the morphology of the anterior mesorectum on sagittal MRI:(1)linear type:the anterior mesorectum was thin and linear;and(2)triangular type:the anterior mesorectum was thick and had a unique triangular shape.Clinicopathological and LR data were compared between patients with linear type anterior mesorectal morphology and patients with triangular type anterior mesorectal morphology.Results:Morphometric analysis showed that 90(51.1%)patients had linear type anterior mesorectal morphology,while 86(48.9%)had triangular type anterior mesorectal morphology.Compared to triangular type anterior mesorectal morphology,linear type anterior mesorectal morphology was more common in females and was associated with a higher risk of circumferential resection margin involvement measured by MRI(35.6%[32/90]vs.16.3%[14/86],P=0.004)and a higher 5-year LR rate(12.2%vs.3.5%,P=0.030).In addition,the combination of linear type anterior mesorectal morphology and anterior tumors was confirmed as an independent risk factor for LR(odds ratio=4.283,P=0.014).Conclusions:The classification established in this study was a simple way to describe morphological characteristics of the anterior mesorectum.The combination of linear type anterior mesorectal morphology and anterior tumors was an independent risk factor for LR and may act as a tool to assist with LR risk stratification and treatment selection.
基金Project(G2002AA336080) supported by Hi-tech Research and Development Program of ChinaProject(50374012) supported by the National Natural Science Foundation of China
文摘The semi-solid slurry of A356 alloy was prepared by low superheat pouring and slightly electromagnetic stirring, in which a pure copper rod was used to produce local chilling. The effect of chilling by the rod on morphology and size of primary α(Al) in A356 was researched. The results indicate that the chilling by the rod remarkably affects the morphology and the size of primary α(Al). Primary α(Al) with particle-like shape is distributed uniformly in A356, and there is no transient area in structure morphology. Compared with the samples prepared without the local chilling, the nucleation rate, morphology and grain size of primary α(Al) in A356 prepared by low superheat pouring and slightly electromagnetic stirring with the rod are markedly improved. Under the condition of chilling, the pouring temperature can be suitably raised to obtain primary α(Al) with particle-like shape.
文摘1 Introduction C<sub>60</sub> crystal is a new form of pure, solid carbon and has been widely investigated. But until now, there still exists the ambiguity in its crystal structure. Early paper showed that C<sub>60</sub> molecules stack in a hexagonal close-packed （hcp） lattice with α=10.02A, c=16.36A, but other ones reported that C<sub>60</sub> crystal has a face-centred-cubic （foe） lattice with α=14.172,. Foc and hcp structures are both stable at room temperature, whereas from the energetic point of view, fcc structure is much stabler. Moreover, the differences in the
基金National Natural Science Foundation of China grant number: 30371717
文摘Objective: To propose a method to segment tongue- images efficiently, and extract tongue- body accurately and quickly. Methods: Firstly, a kind of color- images' pre- processing technique was used to solve tongue- surface reflection problem. Neighbouring and similar region's information was used to restore the region with tongue- surface reflection problem by replacement. Secondly, the restored image was transformed into a gray one, and then processed by mathematical morphological operation- dilation to get a closed- loop edge. The third technique used was watershed algorithm, which is an usual tool in image segmentation. 'Watershed' function of matlab software was used to complete this algorithm. After that, region- combination technique was used. Through measuring neighbourship and similarity of regions, a non- objective and non- background region was merged into one of its neighbouring regions. This step was repeated until only two regions, objective and background regions, were left in the image. At last, corresponding to the merged image, tongue- body image was got from the original image. Results: 316 images were randomly taken from the image library for experiments, and 299 images were correctly segmented, so, the successful ratio is 94.62%. On the other hand, average time of running this method was about 50 s under whole sampling environment. Conclusion: The method presented in this paper can segment a tongue- body image from its original one effectively, and thus laying a good foundation for the following analysis work.
