Even in the early stage,endocrine metabolism disease may lead to micro aneurysms in retinal capillaries whose diameters are less than 10 μm.However,the fundus cameras used in clinic diagnosis can only obtain images o...Even in the early stage,endocrine metabolism disease may lead to micro aneurysms in retinal capillaries whose diameters are less than 10 μm.However,the fundus cameras used in clinic diagnosis can only obtain images of vessels larger than 20 μm in diameter.The human retina is a thin and multiple layer tissue,and the layer of capillaries less than10 μm in diameter only exists in the inner nuclear layer.The layer thickness of capillaries less than 10 μm in diameter is about 40 μm and the distance range to rod＆cone cell surface is tens of micrometers,which varies from person to person.Therefore,determining reasonable capillary layer（CL） position in different human eyes is very difficult.In this paper,we propose a method to determine the position of retinal CL based on the rod＆cone cell layer.The public positions of CL are recognized with 15 subjects from 40 to 59 years old,and the imaging planes of CL are calculated by the effective focal length of the human eye.High resolution retinal capillary imaging results obtained from 17 subjects with a liquid crystal adaptive optics system（LCAOS） validate our method.All of the subjects＇ CLs have public positions from 127 μm to 147 μm from the rod＆cone cell layer,which is influenced by the depth of focus.展开更多
Multi-conjugation adaptive optics（MCAOs） have been investigated and used in the large aperture optical telescopes for high-resolution imaging with large field of view（FOV）.The atmospheric tomographic phase reconst...Multi-conjugation adaptive optics（MCAOs） have been investigated and used in the large aperture optical telescopes for high-resolution imaging with large field of view（FOV）.The atmospheric tomographic phase reconstruction and projection of three-dimensional turbulence volume onto wavefront correctors,such as deformable mirrors（DMs） or liquid crystal wavefront correctors（LCWCs）,is a very important step in the data processing of an MCAO＇s controller.In this paper,a method according to the wavefront reconstruction performance of MCAO is presented to evaluate the optimized configuration of multi laser guide stars（LGSs） and the reasonable conjugation heights of LCWCs.Analytical formulations are derived for the different configurations and are used to generate optimized parameters for MCAO.Several examples are given to demonstrate our LGSs configuration optimization method.Compared with traditional methods,our method has minimum wavefront tomographic error,which will be helpful to get higher imaging resolution at large FOV in MCAO.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11174274,11174279,61205021,11204299,61475152,and 61405194)
文摘Even in the early stage,endocrine metabolism disease may lead to micro aneurysms in retinal capillaries whose diameters are less than 10 μm.However,the fundus cameras used in clinic diagnosis can only obtain images of vessels larger than 20 μm in diameter.The human retina is a thin and multiple layer tissue,and the layer of capillaries less than10 μm in diameter only exists in the inner nuclear layer.The layer thickness of capillaries less than 10 μm in diameter is about 40 μm and the distance range to rod＆cone cell surface is tens of micrometers,which varies from person to person.Therefore,determining reasonable capillary layer（CL） position in different human eyes is very difficult.In this paper,we propose a method to determine the position of retinal CL based on the rod＆cone cell layer.The public positions of CL are recognized with 15 subjects from 40 to 59 years old,and the imaging planes of CL are calculated by the effective focal length of the human eye.High resolution retinal capillary imaging results obtained from 17 subjects with a liquid crystal adaptive optics system（LCAOS） validate our method.All of the subjects＇ CLs have public positions from 127 μm to 147 μm from the rod＆cone cell layer,which is influenced by the depth of focus.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11174274,11174279,61205021,11204299,61475152,and 61405194)the State Key Laboratory of Applied Optics,Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences
文摘Multi-conjugation adaptive optics（MCAOs） have been investigated and used in the large aperture optical telescopes for high-resolution imaging with large field of view（FOV）.The atmospheric tomographic phase reconstruction and projection of three-dimensional turbulence volume onto wavefront correctors,such as deformable mirrors（DMs） or liquid crystal wavefront correctors（LCWCs）,is a very important step in the data processing of an MCAO＇s controller.In this paper,a method according to the wavefront reconstruction performance of MCAO is presented to evaluate the optimized configuration of multi laser guide stars（LGSs） and the reasonable conjugation heights of LCWCs.Analytical formulations are derived for the different configurations and are used to generate optimized parameters for MCAO.Several examples are given to demonstrate our LGSs configuration optimization method.Compared with traditional methods,our method has minimum wavefront tomographic error,which will be helpful to get higher imaging resolution at large FOV in MCAO.
