Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic poten- tial. Despite that, the clinical efficacy of the native curcumin is weak due to its low bioavailability and high met...Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic poten- tial. Despite that, the clinical efficacy of the native curcumin is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with dif- ferent formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability. The purpose of this review is to collate the published clinical studies of cur- cumin products with.improved bioavailability over conventional （unformulated） curcumin. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinet- ics data were included in this review. Further, the data on clinical study design, analytical method, phar- macokinetic parameters and other relevant details of each formulation were extracted. Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attrib- uted to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations. Based on the published reports, NovaSol （185）, CurcuWin （136） and LongVida （100） exhibited over 100-fold higher bioavailability relative to reference unformulated curcumin. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.展开更多
采用液相色谱-串联质谱法(Liquid Chromatograph Mass Spectrometer,LC-MS-MS)测定食品中的那可丁含量,并对不确定度进行评定。通过对实验过程的全面分析,从样品前处理、标准溶液配制和标准曲线拟合等过程评价不确定度;取置信水平P=95%,...采用液相色谱-串联质谱法(Liquid Chromatograph Mass Spectrometer,LC-MS-MS)测定食品中的那可丁含量,并对不确定度进行评定。通过对实验过程的全面分析,从样品前处理、标准溶液配制和标准曲线拟合等过程评价不确定度;取置信水平P=95%,k=2,得出液相色谱-串联质谱法测定食品中那可丁含量的扩展不确定度为57.7μg/kg,食品中的那可丁含量为(221.5±57.7)μg/kg,为食品中那可丁的检测提供了有效可靠、可溯源的数据。展开更多
文摘Curcumin is a widely studied natural compound which has shown tremendous in vitro therapeutic poten- tial. Despite that, the clinical efficacy of the native curcumin is weak due to its low bioavailability and high metabolism in the gastrointestinal tract. During the last decade, researchers have come up with dif- ferent formulations with a focus on improving the bioavailability of curcumin. As a result, a significant number of bioavailable curcumin-based formulations were introduced with the varying range of enhanced bioavailability. The purpose of this review is to collate the published clinical studies of cur- cumin products with.improved bioavailability over conventional （unformulated） curcumin. Based on the literature search, 11 curcumin formulations with available human bioavailability and pharmacokinet- ics data were included in this review. Further, the data on clinical study design, analytical method, phar- macokinetic parameters and other relevant details of each formulation were extracted. Based on a review of these studies, it is evident that better bioavailability of formulated curcumin products is mostly attrib- uted to improved solubility, stability, and possibly low first-pass metabolism. The review hopes to provide a quick reference guide for anyone looking information on these bioavailable curcumin formulations. Based on the published reports, NovaSol （185）, CurcuWin （136） and LongVida （100） exhibited over 100-fold higher bioavailability relative to reference unformulated curcumin. Suggested mechanisms accounting for improved bioavailability of the formulations and details on the bioanalysis methods are also discussed.
文摘采用液相色谱-串联质谱法(Liquid Chromatograph Mass Spectrometer,LC-MS-MS)测定食品中的那可丁含量,并对不确定度进行评定。通过对实验过程的全面分析,从样品前处理、标准溶液配制和标准曲线拟合等过程评价不确定度;取置信水平P=95%,k=2,得出液相色谱-串联质谱法测定食品中那可丁含量的扩展不确定度为57.7μg/kg,食品中的那可丁含量为(221.5±57.7)μg/kg,为食品中那可丁的检测提供了有效可靠、可溯源的数据。
