"数据驱动决策,分析变革教育"的大数据时代推动了技术与教育的深度融合,教育大数据的出现为学习分析技术的发展提供了研究契机,学习分析技术可以有效地发挥教育大数据蕴藏的价值,使数据成为优化学习者学习活动的依据。美国新..."数据驱动决策,分析变革教育"的大数据时代推动了技术与教育的深度融合,教育大数据的出现为学习分析技术的发展提供了研究契机,学习分析技术可以有效地发挥教育大数据蕴藏的价值,使数据成为优化学习者学习活动的依据。美国新媒体联盟连续几年来预测学习分析将成为教育领域的研究主流,学习分析技术与知识国际会议连续五年的举办也为学习分析技术的精细化研究提供了组织保障,该文通过对2011-2015年"学习分析技术与知识"国际会议The International Conference on Learning Analytics and Knowledge,简称LAK的会议论文进行文本挖掘和内容分析,整合了大数据视角下学习分析技术的研究现状和发展趋势以及面对的挑战,以期能够梳理学习分析领域的研究脉络,启示未来的深入研究。展开更多
Coumarins belong to a diverse group of naturally occurring non-nutrient phytochemicals known as benzo-α- pyrones. In this study, esculetin, a 6,7-dihydroxy derivative of coumarin with pleiotropic biological activitie...Coumarins belong to a diverse group of naturally occurring non-nutrient phytochemicals known as benzo-α- pyrones. In this study, esculetin, a 6,7-dihydroxy derivative of coumarin with pleiotropic biological activities, was found to have no significant cytotoxic effect on normal murine macrophages, but it could increase the in vivo migration of the thioglycollate-elicited macrophages in a dose-dependent manner. Moreover, esculetin significantly increased the endocytic activity, and augmented the nitric oxide production and iNOS gene expression in LPS-treated macrophages. In addition, in vivo administration of esculetin into mice was shown to increase the mitogenesis of splenic lymphocytes towards Con A and LPS stimulations, and induced the LAK activity of splenic lymphocytes. Collectively, our results indicate that esculetin could exert immunomodulatory effects on murine macrophages and lymphocytes, both in vitro and in vivo, and this might be one of the possible mechanisms by which coumarins can exert their chemopreventive and anti-tumor activities in vivo. Cellular ＆ Molecular Immunology. 2005;2（3）： 181-188.展开更多
In this study, to explore the radiation protection effects of Lyophyllum Decastes Sing （LDS）, a hot distilled-water extract of LDS was orally administered at a dosage of 250mg/kg every other day for a period of 2 we...In this study, to explore the radiation protection effects of Lyophyllum Decastes Sing （LDS）, a hot distilled-water extract of LDS was orally administered at a dosage of 250mg/kg every other day for a period of 2 weeks in irradiated mice. An automatic blood cell counter was used to measure white blood cells （lymphocytes, monocyte, and granulocytes） one day before X-ray irradiation, and 3 hours, 12 hours, 24 hours, 3 days, 7 days, 15 days and 30 days after irradiation. The Dunnett test was used to examine statistical significance of differences. The peripheral blood cell counts in the Lyophyllum-administered non-irradiation group revealed an increase in the numbers of ieukocytes, lymphocytes and monocytes. For 2 Gy whole body radiation, a significant statistical difference was found between the X-ray group and the Lyophyllum plus X-ray group in the numbers of leukocytes, lymphocytes and monocytes. The results suggest that Lyophyllum restrains blood cell-count falling after irradiation, which is probably mediated at least in part by hemopoietic function, and NK and LAK activities seems to play a role in preventing secondary irffections associated with irradiation.展开更多
文摘"数据驱动决策,分析变革教育"的大数据时代推动了技术与教育的深度融合,教育大数据的出现为学习分析技术的发展提供了研究契机,学习分析技术可以有效地发挥教育大数据蕴藏的价值,使数据成为优化学习者学习活动的依据。美国新媒体联盟连续几年来预测学习分析将成为教育领域的研究主流,学习分析技术与知识国际会议连续五年的举办也为学习分析技术的精细化研究提供了组织保障,该文通过对2011-2015年"学习分析技术与知识"国际会议The International Conference on Learning Analytics and Knowledge,简称LAK的会议论文进行文本挖掘和内容分析,整合了大数据视角下学习分析技术的研究现状和发展趋势以及面对的挑战,以期能够梳理学习分析领域的研究脉络,启示未来的深入研究。
文摘Coumarins belong to a diverse group of naturally occurring non-nutrient phytochemicals known as benzo-α- pyrones. In this study, esculetin, a 6,7-dihydroxy derivative of coumarin with pleiotropic biological activities, was found to have no significant cytotoxic effect on normal murine macrophages, but it could increase the in vivo migration of the thioglycollate-elicited macrophages in a dose-dependent manner. Moreover, esculetin significantly increased the endocytic activity, and augmented the nitric oxide production and iNOS gene expression in LPS-treated macrophages. In addition, in vivo administration of esculetin into mice was shown to increase the mitogenesis of splenic lymphocytes towards Con A and LPS stimulations, and induced the LAK activity of splenic lymphocytes. Collectively, our results indicate that esculetin could exert immunomodulatory effects on murine macrophages and lymphocytes, both in vitro and in vivo, and this might be one of the possible mechanisms by which coumarins can exert their chemopreventive and anti-tumor activities in vivo. Cellular ＆ Molecular Immunology. 2005;2（3）： 181-188.
文摘In this study, to explore the radiation protection effects of Lyophyllum Decastes Sing （LDS）, a hot distilled-water extract of LDS was orally administered at a dosage of 250mg/kg every other day for a period of 2 weeks in irradiated mice. An automatic blood cell counter was used to measure white blood cells （lymphocytes, monocyte, and granulocytes） one day before X-ray irradiation, and 3 hours, 12 hours, 24 hours, 3 days, 7 days, 15 days and 30 days after irradiation. The Dunnett test was used to examine statistical significance of differences. The peripheral blood cell counts in the Lyophyllum-administered non-irradiation group revealed an increase in the numbers of ieukocytes, lymphocytes and monocytes. For 2 Gy whole body radiation, a significant statistical difference was found between the X-ray group and the Lyophyllum plus X-ray group in the numbers of leukocytes, lymphocytes and monocytes. The results suggest that Lyophyllum restrains blood cell-count falling after irradiation, which is probably mediated at least in part by hemopoietic function, and NK and LAK activities seems to play a role in preventing secondary irffections associated with irradiation.
