Introduction:In the past several decades,declining incidences of nasopharyngeal carcinoma(NPC) have been observed in Chinese populations in Hong Kong,Taiwan,Los Angeles,and Singapore.A previous study indicated that th...Introduction:In the past several decades,declining incidences of nasopharyngeal carcinoma(NPC) have been observed in Chinese populations in Hong Kong,Taiwan,Los Angeles,and Singapore.A previous study indicated that the incidence of NPC in Sihui County,South China remained stable until 2002,but whether age,diagnosis period,and birth cohort affect the incidence of NPC remains unknown.Methods:Age-standardized rates(ASRs) of NPC incidence based on the world standard population were examined in both males and females in Sihui County from 1987 to 2011.Joinpoint regression analysis was conducted to quantify the changes in incidence trends.A Poisson regression age-period-cohort model was used to assess the effects of age,diagnosis period,and birth cohort on the risk of NPC.Results:The ASRs of NPC incidence during the study period were 30.29/100,000 for males and 13.09/100,000 for females.The incidence of NPC remained stable at a non-significant average annual percent change of 0.2%for males and-1.6%for females throughout the entire period.A significantly increased estimated annual percent change of 6.8%(95%confidence interval,0.1%-14.0%) was observed from 2003 to 2009 for males.The relative risk of NPC increased with advancing age up to 50-59 and decreased at ages >60 years.The period effect curves on NPC were nearly flat for males and females.The birth cohort effect curve for males showed an increase from the1922 cohort to the 1957 cohort and a decrease thereafter.In females,there was an undulating increase in the relative risk from the 1922 cohort to the 1972 cohort.Conclusions:The incidence trends for NPC remained generally stable in Sihui from 1987 to 2011,with an increase from 2003 to 2009.The relative risks of NPC increased in younger females.展开更多
目的了解中国近30年白血病疾病负担情况及发展变化趋势,为中国白血病干预与治疗策略的制定提供参考借鉴。方法利用2019年全球疾病负担数据库提取中国白血病发病、死亡、伤残调整生命年(disability adjusted life year,DALY)等数据并计...目的了解中国近30年白血病疾病负担情况及发展变化趋势,为中国白血病干预与治疗策略的制定提供参考借鉴。方法利用2019年全球疾病负担数据库提取中国白血病发病、死亡、伤残调整生命年(disability adjusted life year,DALY)等数据并计算其标化率,利用Joinpoint回归模型拟合年代变化趋势,并寻找有意义的转折点。结果1990—2019年中国白血病发病率、死亡率、DALY率均呈下降趋势,死亡率总体年均下降1.8%,男性年均下降1.5%,女性年均下降2.2%;发病率总体年均下降2.4%,男性年均下降2.1%,女性年均下降2.2%;DALY率总体年均下降1.8%,男性年均下降0.4%,女性年均下降1.0%。组间比较结果显示,总体、男性、女性发病率、死亡率、DALY率变化趋势的差异均具有统计学意义。结论近30年来中国白血病疾病负担有所下降,但是发病率开始出现回升,在城市化、工业化、老龄化的影响下,白血病疾病负担可能会持续加重,今后还需加强对白血病发病机制与危险因素的研究,针对重点人群采取积极的干预措施,减缓白血病疾病负担的加重。展开更多
文摘Introduction:In the past several decades,declining incidences of nasopharyngeal carcinoma(NPC) have been observed in Chinese populations in Hong Kong,Taiwan,Los Angeles,and Singapore.A previous study indicated that the incidence of NPC in Sihui County,South China remained stable until 2002,but whether age,diagnosis period,and birth cohort affect the incidence of NPC remains unknown.Methods:Age-standardized rates(ASRs) of NPC incidence based on the world standard population were examined in both males and females in Sihui County from 1987 to 2011.Joinpoint regression analysis was conducted to quantify the changes in incidence trends.A Poisson regression age-period-cohort model was used to assess the effects of age,diagnosis period,and birth cohort on the risk of NPC.Results:The ASRs of NPC incidence during the study period were 30.29/100,000 for males and 13.09/100,000 for females.The incidence of NPC remained stable at a non-significant average annual percent change of 0.2%for males and-1.6%for females throughout the entire period.A significantly increased estimated annual percent change of 6.8%(95%confidence interval,0.1%-14.0%) was observed from 2003 to 2009 for males.The relative risk of NPC increased with advancing age up to 50-59 and decreased at ages >60 years.The period effect curves on NPC were nearly flat for males and females.The birth cohort effect curve for males showed an increase from the1922 cohort to the 1957 cohort and a decrease thereafter.In females,there was an undulating increase in the relative risk from the 1922 cohort to the 1972 cohort.Conclusions:The incidence trends for NPC remained generally stable in Sihui from 1987 to 2011,with an increase from 2003 to 2009.The relative risks of NPC increased in younger females.
文摘目的了解中国近30年白血病疾病负担情况及发展变化趋势,为中国白血病干预与治疗策略的制定提供参考借鉴。方法利用2019年全球疾病负担数据库提取中国白血病发病、死亡、伤残调整生命年(disability adjusted life year,DALY)等数据并计算其标化率,利用Joinpoint回归模型拟合年代变化趋势,并寻找有意义的转折点。结果1990—2019年中国白血病发病率、死亡率、DALY率均呈下降趋势,死亡率总体年均下降1.8%,男性年均下降1.5%,女性年均下降2.2%;发病率总体年均下降2.4%,男性年均下降2.1%,女性年均下降2.2%;DALY率总体年均下降1.8%,男性年均下降0.4%,女性年均下降1.0%。组间比较结果显示,总体、男性、女性发病率、死亡率、DALY率变化趋势的差异均具有统计学意义。结论近30年来中国白血病疾病负担有所下降,但是发病率开始出现回升,在城市化、工业化、老龄化的影响下,白血病疾病负担可能会持续加重,今后还需加强对白血病发病机制与危险因素的研究,针对重点人群采取积极的干预措施,减缓白血病疾病负担的加重。
