目的回顾性分析营养性缺铁性贫血(nutritional iron deficiency anemia,IDA)患儿的病例资料,考察其发病率与发病的相关因素,探讨对IDA患儿进行健康管理干预和治疗的临床效果。方法回顾性分析绍兴市人民医院2014年1月—2016年12月接诊的...目的回顾性分析营养性缺铁性贫血(nutritional iron deficiency anemia,IDA)患儿的病例资料,考察其发病率与发病的相关因素,探讨对IDA患儿进行健康管理干预和治疗的临床效果。方法回顾性分析绍兴市人民医院2014年1月—2016年12月接诊的疑似IDA患儿的病历资料,对其中5例确诊为IDA患儿均施行系统的持续性健康管理干预,必要的补铁治疗。考察小儿营养性缺铁性贫血(nutritional iron deficiency anemia of children,IDAC)的发病率;采用单因素分析考察IDA患儿发病的相关因素;比较经健康管理干预和治疗前、后患儿临床症状、体征及体重的变化,实验室相关指标血红蛋白(HGB)、血铁。结果 (1)51例(占14.57%,51/350)患儿确诊为IDA,其实验室检查外周血中的血红蛋白、血铁蛋白(Fer)含量均低于非IDA患儿差异有统计学意义(P<0.05)。1~3岁(含)幼儿的发病率最高。(2)经单因素分析发现,年龄、主要喂养方式、合并消化系统等疾病均为引起IDAC的相关因素。(3)经健康管理干预和治疗后,多数IDA患儿实验室指标中的血红蛋白、血铁蛋白及患儿体重均基本恢复至本院实验室正常参考值范围内。多数(96.08%,49例)患儿贫血及临床不适症状或异常体征得到有效的改善。结论 IDAC以1~3岁(含)幼儿多发,患病原因主要为膳食结构不合理、合并消化系统疾病等。对IDA患儿施行合理、持续的健康管理干预和治疗多可获得较为满意的临床效果。展开更多
Purpose: Due to the high prevalence of iron deficiency anemia in women undergoing gynecological surgeries and its association with worse postoperative results, it is necessary to identify and treat anemia preoperative...Purpose: Due to the high prevalence of iron deficiency anemia in women undergoing gynecological surgeries and its association with worse postoperative results, it is necessary to identify and treat anemia preoperatively. However, although anemia and iron deficiency are significant global health problems, there are still disparities in the recognition and implementation of “Patient Blood Management” (PBM) as a comprehensive approach to mitigating the risks associated with these diseases. The purpose of the study is to review best practices for the treatment of anemia based on the Enhanced Recovery After Surgery (ERAS) protocol and PBM recommendations. Methods: This study reviewed the literature on preoperative iron deficiency anemia in patients undergoing gynecological surgery. We identified references through searches in PubMed using relevant search terms. Results: Among the various strategies used in PBM, perhaps the most important is the early detection and management of anemia. In gynecological surgery, there are several approaches to reducing perioperative blood loss, highlighting the use of gonadotropin-releasing hormone (GnRH) agonists (aGnRh) and antifibrinolytics. Oral and intravenous iron supplementation can be performed in addition to blood transfusion to treat anemia. Conclusion: Addressing preoperative and postoperative anemia through systematic correction, following the guidelines of the ERAS protocol and PBM guidelines, is essential to improving perioperative outcomes in women undergoing gynecological surgery.展开更多
不宁腿综合征(restless legs syndrome,RLS)是一种常见的神经系统疾病,特点是不舒服的腿部冲动,在运动或起身行走时缓解,并在夜间症状加重。RLS的发病机制仍不清楚,但随着病理生理学研究的进展,发现可能涉及中枢神经系统的多巴胺功能障...不宁腿综合征(restless legs syndrome,RLS)是一种常见的神经系统疾病,特点是不舒服的腿部冲动,在运动或起身行走时缓解,并在夜间症状加重。RLS的发病机制仍不清楚,但随着病理生理学研究的进展,发现可能涉及中枢神经系统的多巴胺功能障碍,以及其他未确定的促进机制,特别是缺铁和慢性肾功能障碍。有家族史的遗传易感性很常见。RLS增强的特点是症状的严重性更强,症状发生的时间更早,而且常常是症状从腿部扩散至手臂或身体其他区域。一些RLS患者通过非药物措施,如按摩和温水浴,可以充分控制症状。一线治疗方案包括对体内铁储存减少的人进行铁补充治疗,或使用加巴喷丁、普瑞巴林,以及多巴胺激动剂,如普拉克索、罗匹尼罗和罗替戈汀。二线疗法包括曲马多、羟考酮和美沙酮等阿片类药物。RLS严重影响患者的生活质量,且仍是一个非常需要创新的治疗领域,需要有更多新的、有生物依据的治疗方法。展开更多
Background:?Due to maternal and fetal physiologic demand, the rate along with amplitude of anemia is expected to rise over pregnancy. The iron and oxidative status also are expected to vary accordingly. It is thus ass...Background:?Due to maternal and fetal physiologic demand, the rate along with amplitude of anemia is expected to rise over pregnancy. The iron and oxidative status also are expected to vary accordingly. It is thus assumed that iron supplementation will somewhat modify the profile observed in markers of iron and oxidative status of our series. Objectives: We aimed to measure variations of indices of iron and oxidative status of iron supplemented women over pregnancy. Methods: This is a prospective observational cohort of 74 pregnant women with singleton pregnancy whose baseline iron and oxidative status have been recently assessed at University Clinics of Kinshasa, DR Congo. Women with anemia (Hb < 10 g%) took iron for curative purposes (320 mg/day of ferric ammonium citrate) while the others received preventive iron supplementation (160 mg/day). Iron was associated with 15 mg folate/day. Nutritional iron intake was measured through a 24-hour recall using a questionnaire of common foods, including stuffs and habits likely to impede iron absorption. Biological parameters of iron and oxidative status included hemoglobin, hematocrit, ferritin, serum iron, transferrin, superoxide dismutase or SOD, uric acid, oxidized LDL and blood glucose. For statistical calculations we used t-test, chi-square test, ANOVAR and regression, the significance being stated at p Results: Trimester wise evolution of hematologic status in anemic women shows a rise in values of hemoglobin (+average 1 gr/dl) and hematocrit (+3%) throughout pregnancy, with significant change only between recruitment and 28 - 32 weeks. In non anemic women a significant decrease was observed, although levels remained normal. For ferritin (7.5 - 53 ng/mL from recruitment to term) and transferrin (107 - 157 g/L), significant rise was found in anemic women from recruitment to 28 - 32 weeks, while in non anemic notable change occurred only for transferrin (133 - 204 g/L). Serum iron significantly increased (53 - 83 μg/dL) from recruitment to 28 - 32 weeks in anemic 展开更多
<b><span style="font-family:Verdana;">Introduction: </span></b><span style="font-family:Verdana;">It is estimated that about 18% of pregnant women suffer from iron def...<b><span style="font-family:Verdana;">Introduction: </span></b><span style="font-family:Verdana;">It is estimated that about 18% of pregnant women suffer from iron deficiency anemia throughout their whole pregnancy.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">In </span><span style="font-family:Verdana;">twin</span><span style="font-family:Verdana;"> pregnancy, owing to the relatively greater </span><span style="font-family:Verdana;">feto-placental</span><span style="font-family:Verdana;"> requirements and greater expansion in maternal plasma volume </span></span><span style="font-family:Verdana;">and red cell mass, iron requirements </span><span style="font-family:""><span style="font-family:Verdana;">are magnified 1.8 times compared to singleton pregnancies. However, for </span><span style="font-family:Verdana;">prevention</span><span style="font-family:Verdana;"> of iron deficiency in twin </span><span style="font-family:Verdana;">pregnancy</span><span style="font-family:Verdana;">, only sparse data exist regarding the sufficiency of the standard antenatal iron supplementation dose used in singleton pregnancies to meet the increased iron demand. In this study, we investigate the effect of single and double dose iron supplementation for </span><span style="font-family:Verdana;">prevention</span><span style="font-family:Verdana;"> of iron deficiency anemia in twin pregnancy. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A randomized controlled clinical trial was conducted at our center in the period between February 2019 and October 2020,</span></span><span style="font-family:Verdana;"> and</span><span style="font-family:""> <span style="font-family:Verdana;">included</span><span style="font-family:Verdana;"> 450 eligible healthy non-anemic women aged 18 </span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 35 years, with twin pregnancy at 12 </span><span style=展开更多
文摘目的回顾性分析营养性缺铁性贫血(nutritional iron deficiency anemia,IDA)患儿的病例资料,考察其发病率与发病的相关因素,探讨对IDA患儿进行健康管理干预和治疗的临床效果。方法回顾性分析绍兴市人民医院2014年1月—2016年12月接诊的疑似IDA患儿的病历资料,对其中5例确诊为IDA患儿均施行系统的持续性健康管理干预,必要的补铁治疗。考察小儿营养性缺铁性贫血(nutritional iron deficiency anemia of children,IDAC)的发病率;采用单因素分析考察IDA患儿发病的相关因素;比较经健康管理干预和治疗前、后患儿临床症状、体征及体重的变化,实验室相关指标血红蛋白(HGB)、血铁。结果 (1)51例(占14.57%,51/350)患儿确诊为IDA,其实验室检查外周血中的血红蛋白、血铁蛋白(Fer)含量均低于非IDA患儿差异有统计学意义(P<0.05)。1~3岁(含)幼儿的发病率最高。(2)经单因素分析发现,年龄、主要喂养方式、合并消化系统等疾病均为引起IDAC的相关因素。(3)经健康管理干预和治疗后,多数IDA患儿实验室指标中的血红蛋白、血铁蛋白及患儿体重均基本恢复至本院实验室正常参考值范围内。多数(96.08%,49例)患儿贫血及临床不适症状或异常体征得到有效的改善。结论 IDAC以1~3岁(含)幼儿多发,患病原因主要为膳食结构不合理、合并消化系统疾病等。对IDA患儿施行合理、持续的健康管理干预和治疗多可获得较为满意的临床效果。
文摘Purpose: Due to the high prevalence of iron deficiency anemia in women undergoing gynecological surgeries and its association with worse postoperative results, it is necessary to identify and treat anemia preoperatively. However, although anemia and iron deficiency are significant global health problems, there are still disparities in the recognition and implementation of “Patient Blood Management” (PBM) as a comprehensive approach to mitigating the risks associated with these diseases. The purpose of the study is to review best practices for the treatment of anemia based on the Enhanced Recovery After Surgery (ERAS) protocol and PBM recommendations. Methods: This study reviewed the literature on preoperative iron deficiency anemia in patients undergoing gynecological surgery. We identified references through searches in PubMed using relevant search terms. Results: Among the various strategies used in PBM, perhaps the most important is the early detection and management of anemia. In gynecological surgery, there are several approaches to reducing perioperative blood loss, highlighting the use of gonadotropin-releasing hormone (GnRH) agonists (aGnRh) and antifibrinolytics. Oral and intravenous iron supplementation can be performed in addition to blood transfusion to treat anemia. Conclusion: Addressing preoperative and postoperative anemia through systematic correction, following the guidelines of the ERAS protocol and PBM guidelines, is essential to improving perioperative outcomes in women undergoing gynecological surgery.
文摘不宁腿综合征(restless legs syndrome,RLS)是一种常见的神经系统疾病,特点是不舒服的腿部冲动,在运动或起身行走时缓解,并在夜间症状加重。RLS的发病机制仍不清楚,但随着病理生理学研究的进展,发现可能涉及中枢神经系统的多巴胺功能障碍,以及其他未确定的促进机制,特别是缺铁和慢性肾功能障碍。有家族史的遗传易感性很常见。RLS增强的特点是症状的严重性更强,症状发生的时间更早,而且常常是症状从腿部扩散至手臂或身体其他区域。一些RLS患者通过非药物措施,如按摩和温水浴,可以充分控制症状。一线治疗方案包括对体内铁储存减少的人进行铁补充治疗,或使用加巴喷丁、普瑞巴林,以及多巴胺激动剂,如普拉克索、罗匹尼罗和罗替戈汀。二线疗法包括曲马多、羟考酮和美沙酮等阿片类药物。RLS严重影响患者的生活质量,且仍是一个非常需要创新的治疗领域,需要有更多新的、有生物依据的治疗方法。
文摘Background:?Due to maternal and fetal physiologic demand, the rate along with amplitude of anemia is expected to rise over pregnancy. The iron and oxidative status also are expected to vary accordingly. It is thus assumed that iron supplementation will somewhat modify the profile observed in markers of iron and oxidative status of our series. Objectives: We aimed to measure variations of indices of iron and oxidative status of iron supplemented women over pregnancy. Methods: This is a prospective observational cohort of 74 pregnant women with singleton pregnancy whose baseline iron and oxidative status have been recently assessed at University Clinics of Kinshasa, DR Congo. Women with anemia (Hb < 10 g%) took iron for curative purposes (320 mg/day of ferric ammonium citrate) while the others received preventive iron supplementation (160 mg/day). Iron was associated with 15 mg folate/day. Nutritional iron intake was measured through a 24-hour recall using a questionnaire of common foods, including stuffs and habits likely to impede iron absorption. Biological parameters of iron and oxidative status included hemoglobin, hematocrit, ferritin, serum iron, transferrin, superoxide dismutase or SOD, uric acid, oxidized LDL and blood glucose. For statistical calculations we used t-test, chi-square test, ANOVAR and regression, the significance being stated at p Results: Trimester wise evolution of hematologic status in anemic women shows a rise in values of hemoglobin (+average 1 gr/dl) and hematocrit (+3%) throughout pregnancy, with significant change only between recruitment and 28 - 32 weeks. In non anemic women a significant decrease was observed, although levels remained normal. For ferritin (7.5 - 53 ng/mL from recruitment to term) and transferrin (107 - 157 g/L), significant rise was found in anemic women from recruitment to 28 - 32 weeks, while in non anemic notable change occurred only for transferrin (133 - 204 g/L). Serum iron significantly increased (53 - 83 μg/dL) from recruitment to 28 - 32 weeks in anemic
文摘<b><span style="font-family:Verdana;">Introduction: </span></b><span style="font-family:Verdana;">It is estimated that about 18% of pregnant women suffer from iron deficiency anemia throughout their whole pregnancy.</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">In </span><span style="font-family:Verdana;">twin</span><span style="font-family:Verdana;"> pregnancy, owing to the relatively greater </span><span style="font-family:Verdana;">feto-placental</span><span style="font-family:Verdana;"> requirements and greater expansion in maternal plasma volume </span></span><span style="font-family:Verdana;">and red cell mass, iron requirements </span><span style="font-family:""><span style="font-family:Verdana;">are magnified 1.8 times compared to singleton pregnancies. However, for </span><span style="font-family:Verdana;">prevention</span><span style="font-family:Verdana;"> of iron deficiency in twin </span><span style="font-family:Verdana;">pregnancy</span><span style="font-family:Verdana;">, only sparse data exist regarding the sufficiency of the standard antenatal iron supplementation dose used in singleton pregnancies to meet the increased iron demand. In this study, we investigate the effect of single and double dose iron supplementation for </span><span style="font-family:Verdana;">prevention</span><span style="font-family:Verdana;"> of iron deficiency anemia in twin pregnancy. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A randomized controlled clinical trial was conducted at our center in the period between February 2019 and October 2020,</span></span><span style="font-family:Verdana;"> and</span><span style="font-family:""> <span style="font-family:Verdana;">included</span><span style="font-family:Verdana;"> 450 eligible healthy non-anemic women aged 18 </span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> 35 years, with twin pregnancy at 12 </span><span style=
