Synthetic biology provides a new paradigm for life science research(“build to learn”)and opens the future journey of biotechnology(“build to use”).Here,we discuss advances of various principles and technologies in...Synthetic biology provides a new paradigm for life science research(“build to learn”)and opens the future journey of biotechnology(“build to use”).Here,we discuss advances of various principles and technologies in the mainstream of the enabling technology of synthetic biology,including synthesis and assembly of a genome,DNA storage,gene editing,molecular evolution and de novo design of function proteins,cell and gene circuit engineering,cell-free synthetic biology,artificial intelligence(AI)-aided synthetic biology,as well as biofoundries.We also introduce the concept of quantitative synthetic biology,which is guiding synthetic biology towards increased accuracy and predictability or the real rational design.We conclude that synthetic biology will establish its disciplinary system with the iterative development of enabling technologies and the maturity of the core theory.展开更多
With the rapid development of low-orbit satellite com-munication networks both domestically and internationally,space-terrestrial integrated networks will become the future development trend.For space and terrestrial ...With the rapid development of low-orbit satellite com-munication networks both domestically and internationally,space-terrestrial integrated networks will become the future development trend.For space and terrestrial networks with limi-ted resources,the utilization efficiency of the entire space-terres-trial integrated networks resources can be affected by the core network indirectly.In order to improve the response efficiency of core networks expansion construction,early warning of the core network elements capacity is necessary.Based on the inte-grated architecture of space and terrestrial network,multidimen-sional factors are considered in this paper,including the number of terminals,login users,and the rules of users’migration during holidays.Using artifical intelligence(AI)technologies,the regis-tered users of the access and mobility management function(AMF),authorization users of the unified data management(UDM),protocol data unit(PDU)sessions of session manage-ment function(SMF)are predicted in combination with the num-ber of login users,the number of terminals.Therefore,the core network elements capacity can be predicted in advance.The proposed method is proven to be effective based on the data from real network.展开更多
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29050100,XDB29050500,XDA24020102)to X.E.Zhang,C.Liu and C.Gao,respectivelythe National Natural Science Foundation of China(31725002,31861143017,32022044,62050152 and 32071428)to J.Dai,Y.Yuan,C.You,and X.Wang,respectivelythe National Key Research and Development Program of China(2020YFA0907700,2018YFA0901600,2019YFA09004500)to Y.Feng and P.Wei。
文摘Synthetic biology provides a new paradigm for life science research(“build to learn”)and opens the future journey of biotechnology(“build to use”).Here,we discuss advances of various principles and technologies in the mainstream of the enabling technology of synthetic biology,including synthesis and assembly of a genome,DNA storage,gene editing,molecular evolution and de novo design of function proteins,cell and gene circuit engineering,cell-free synthetic biology,artificial intelligence(AI)-aided synthetic biology,as well as biofoundries.We also introduce the concept of quantitative synthetic biology,which is guiding synthetic biology towards increased accuracy and predictability or the real rational design.We conclude that synthetic biology will establish its disciplinary system with the iterative development of enabling technologies and the maturity of the core theory.
基金This work was supported by the National Key Research Plan(2021YFB2900602).
文摘With the rapid development of low-orbit satellite com-munication networks both domestically and internationally,space-terrestrial integrated networks will become the future development trend.For space and terrestrial networks with limi-ted resources,the utilization efficiency of the entire space-terres-trial integrated networks resources can be affected by the core network indirectly.In order to improve the response efficiency of core networks expansion construction,early warning of the core network elements capacity is necessary.Based on the inte-grated architecture of space and terrestrial network,multidimen-sional factors are considered in this paper,including the number of terminals,login users,and the rules of users’migration during holidays.Using artifical intelligence(AI)technologies,the regis-tered users of the access and mobility management function(AMF),authorization users of the unified data management(UDM),protocol data unit(PDU)sessions of session manage-ment function(SMF)are predicted in combination with the num-ber of login users,the number of terminals.Therefore,the core network elements capacity can be predicted in advance.The proposed method is proven to be effective based on the data from real network.
