Background:Cognitive impairment is prevalent among older adults and results in degraded quality of life for older adults.As the population ages,this may cause a huge burden to society.Research has demonstrated that ph...Background:Cognitive impairment is prevalent among older adults and results in degraded quality of life for older adults.As the population ages,this may cause a huge burden to society.Research has demonstrated that physical exercise is beneficial to cognitive function.The purpose of this meta-analysis was to critically assess the effect of Tai Chi exercise on global cognitive,executive,and memory functions in older adults.Methods:After a thorough electronic search and selection,eight studies were included in this meta-analysis with two cross-sectional and six intervention studies.Nine variables included in this meta-analysis were:mini mental status examination(MMSE),Alzheimer’s disease assessment scale-cognitive subscale(ADAS-cog),trailmaking test part A(TMA),trailmaking test part B(TMB),digit span test forward(DSF),digit span test backward(DSB),visual span test backward(VSB),verbal fluency test(VFT),and word delay recall test(WDR).The effect sizes and forest plots of these nine variables were generated.Results:Four(MMSE,DSB,VSB,and VFT)out of nine variables were significantly improved after Tai Chi exercise with the effect sizes ranged from 0.20 to 0.46(small to medium).MMSE represented global cognitive function,and DSB,VSB,and VFT represented memory function.Conclusion:Tai Chi as a mind-body exercise has the positive effects on global cognitive and memory functions,and more consistent positive effects were found on memory function,especially verbal working memory.展开更多
目的:探讨侧脑室周围白质软化症(periventricular leukomalacia,PVL)脑瘫患儿的临床及MRI特点。方法:从我院电子病历信息系统中回顾性提取自2011年1月1日至2021年12月31日在郑州大学第三附属医院儿童康复科住院康复的18岁以下脑瘫儿童信...目的:探讨侧脑室周围白质软化症(periventricular leukomalacia,PVL)脑瘫患儿的临床及MRI特点。方法:从我院电子病历信息系统中回顾性提取自2011年1月1日至2021年12月31日在郑州大学第三附属医院儿童康复科住院康复的18岁以下脑瘫儿童信息,比较和分析头颅MRI表现为PVL脑瘫患儿的孕周、出生体重、分型、粗大运动功能分级(gross motor function classification system,GMFCS)、共患病等方面的不同。结果:共纳入2012例脑瘫患儿,进行头颅MRI检查并有结果记录者共1419例,PVL共645例(45.45%),早产417例(64.65%),低出生体重患儿375例(58.14%);在有PVL分级结果的321例患儿中,PVL分级为Ⅱ级者在孕周<32周脑瘫患儿中占比最高,为72.53%(8/77),孕周与PVL分级有统计学差异(P<0.01);在出生体重方面,PVL分级为Ⅱ级者在出生体重1500~2500 g及<1500 g脑瘫患儿中占比分别为71.21%(94/132)和62.5%(25/40),不同出生体重儿的PVL分级分布差异均有统计学意义(P<0.05)。在型别方面,痉挛型双瘫占比57.36%(370/645),痉挛型四肢瘫占比17.36%(112/645);在GMFCS分级方面,具有独走能力者占比65.89%(425/645)。在有PVL分级结果的321例患儿中,PVL为Ⅲ级者痉挛型偏瘫占比最高,为53.49%(46/86),在GMFCS分级方面,PVL分级为Ⅱ级者GMFCS为Ⅰ、Ⅱ级者占比最低,为48.84%(105/215),型别、GMFCS分级与PVL分级之间差异均有统计学意义(P<0.01);在共患病方面,最后一次随访年龄>4岁的有505例,其中共患智力障碍181例(35.84%),共患癫痫78例(12.09%),共患视力障碍71例(11.01%)。在有PVL分级结果的321例患儿中,PVL分级为Ⅱ级者共患癫痫及智力障碍率均最高,分别为17.03%(31/182)和40.16%(49/122),PVL分级与是否共患癫痫及智力障碍均存在统计学差异(均P<0.05),PVL分级与是否共患听力障碍、视力障碍均无统计学意义(P>0.05)。结论:头颅MRI为PVL的脑瘫患儿的孕周、临床表现、合并症呈现一定的特点,头颅MRI可以�展开更多
分析1例青年起病的成人糖尿病11型(maturity-onset diabetes of the young,MODY11)的基因型和临床特征并做文献复习。患者为30岁女性,血糖升高2年,伴生长发育迟缓、原发性闭经、智力低下、严重高脂血症。患者外周血基因测序发现B淋巴细...分析1例青年起病的成人糖尿病11型(maturity-onset diabetes of the young,MODY11)的基因型和临床特征并做文献复习。患者为30岁女性,血糖升高2年,伴生长发育迟缓、原发性闭经、智力低下、严重高脂血症。患者外周血基因测序发现B淋巴细胞激酶(B lymphocyte kinase,BLK)基因外显子区域杂合突变c.1025C>T(p.A342V)。文献复习已知,BLK-MODY11突变位点报道迄今约10种,临床表现为高血糖外,多数有超重或肥胖,可合并系统性红斑狼疮。而本患者生长发育迟缓、原发性闭经、智力低下等临床特点均未在以往MODY11研究中报道。本研究报告病例进一步扩展了MODY11的新突变位点及临床表现多样性。展开更多
文摘Background:Cognitive impairment is prevalent among older adults and results in degraded quality of life for older adults.As the population ages,this may cause a huge burden to society.Research has demonstrated that physical exercise is beneficial to cognitive function.The purpose of this meta-analysis was to critically assess the effect of Tai Chi exercise on global cognitive,executive,and memory functions in older adults.Methods:After a thorough electronic search and selection,eight studies were included in this meta-analysis with two cross-sectional and six intervention studies.Nine variables included in this meta-analysis were:mini mental status examination(MMSE),Alzheimer’s disease assessment scale-cognitive subscale(ADAS-cog),trailmaking test part A(TMA),trailmaking test part B(TMB),digit span test forward(DSF),digit span test backward(DSB),visual span test backward(VSB),verbal fluency test(VFT),and word delay recall test(WDR).The effect sizes and forest plots of these nine variables were generated.Results:Four(MMSE,DSB,VSB,and VFT)out of nine variables were significantly improved after Tai Chi exercise with the effect sizes ranged from 0.20 to 0.46(small to medium).MMSE represented global cognitive function,and DSB,VSB,and VFT represented memory function.Conclusion:Tai Chi as a mind-body exercise has the positive effects on global cognitive and memory functions,and more consistent positive effects were found on memory function,especially verbal working memory.
文摘目的:探讨侧脑室周围白质软化症(periventricular leukomalacia,PVL)脑瘫患儿的临床及MRI特点。方法:从我院电子病历信息系统中回顾性提取自2011年1月1日至2021年12月31日在郑州大学第三附属医院儿童康复科住院康复的18岁以下脑瘫儿童信息,比较和分析头颅MRI表现为PVL脑瘫患儿的孕周、出生体重、分型、粗大运动功能分级(gross motor function classification system,GMFCS)、共患病等方面的不同。结果:共纳入2012例脑瘫患儿,进行头颅MRI检查并有结果记录者共1419例,PVL共645例(45.45%),早产417例(64.65%),低出生体重患儿375例(58.14%);在有PVL分级结果的321例患儿中,PVL分级为Ⅱ级者在孕周<32周脑瘫患儿中占比最高,为72.53%(8/77),孕周与PVL分级有统计学差异(P<0.01);在出生体重方面,PVL分级为Ⅱ级者在出生体重1500~2500 g及<1500 g脑瘫患儿中占比分别为71.21%(94/132)和62.5%(25/40),不同出生体重儿的PVL分级分布差异均有统计学意义(P<0.05)。在型别方面,痉挛型双瘫占比57.36%(370/645),痉挛型四肢瘫占比17.36%(112/645);在GMFCS分级方面,具有独走能力者占比65.89%(425/645)。在有PVL分级结果的321例患儿中,PVL为Ⅲ级者痉挛型偏瘫占比最高,为53.49%(46/86),在GMFCS分级方面,PVL分级为Ⅱ级者GMFCS为Ⅰ、Ⅱ级者占比最低,为48.84%(105/215),型别、GMFCS分级与PVL分级之间差异均有统计学意义(P<0.01);在共患病方面,最后一次随访年龄>4岁的有505例,其中共患智力障碍181例(35.84%),共患癫痫78例(12.09%),共患视力障碍71例(11.01%)。在有PVL分级结果的321例患儿中,PVL分级为Ⅱ级者共患癫痫及智力障碍率均最高,分别为17.03%(31/182)和40.16%(49/122),PVL分级与是否共患癫痫及智力障碍均存在统计学差异(均P<0.05),PVL分级与是否共患听力障碍、视力障碍均无统计学意义(P>0.05)。结论:头颅MRI为PVL的脑瘫患儿的孕周、临床表现、合并症呈现一定的特点,头颅MRI可以�
文摘分析1例青年起病的成人糖尿病11型(maturity-onset diabetes of the young,MODY11)的基因型和临床特征并做文献复习。患者为30岁女性,血糖升高2年,伴生长发育迟缓、原发性闭经、智力低下、严重高脂血症。患者外周血基因测序发现B淋巴细胞激酶(B lymphocyte kinase,BLK)基因外显子区域杂合突变c.1025C>T(p.A342V)。文献复习已知,BLK-MODY11突变位点报道迄今约10种,临床表现为高血糖外,多数有超重或肥胖,可合并系统性红斑狼疮。而本患者生长发育迟缓、原发性闭经、智力低下等临床特点均未在以往MODY11研究中报道。本研究报告病例进一步扩展了MODY11的新突变位点及临床表现多样性。
