Effects of tranquil and its inhalation toxicity in experimental animals were studied. The drug was administered to the mice through respiratory tract by a static intoxication equipment. Automatic activities (AA) of mi...Effects of tranquil and its inhalation toxicity in experimental animals were studied. The drug was administered to the mice through respiratory tract by a static intoxication equipment. Automatic activities (AA) of mice were recorded by a YSD4G pharmacologicalphysiological multitrack recording equipment to evaluate the combined effects of tranquil and pentobarbital. Changes in amount of cerebral 5hydroxytryptamine(5HT) and 5hydroxyindole acetic acid (5HIAA) were observed. The results showed that tranquil could reduce the AA of mice and exert a synergic hypnotic effect with pentobarbital. There was a tendency in decreasing cerebral 5HT and increasing 5HIAA. LC50 value for mice exceeded 70 000 mg/m\+3. In rats exposed to tranquil at 59 066 mg/m\+3, 4 hours every day for 3 consecutive days, Author no respiratory irritative action was observed. This indicated the inhibitory effects of tranquil on the CNS of mice. Its action mechanism is probably different from that of diazepam and may be related to the function of central neurotransmitter 5hydroxytryptamine. Tranquil has low inhalation toxicity and no irritative action on the respiratory tract.\;展开更多
文摘Effects of tranquil and its inhalation toxicity in experimental animals were studied. The drug was administered to the mice through respiratory tract by a static intoxication equipment. Automatic activities (AA) of mice were recorded by a YSD4G pharmacologicalphysiological multitrack recording equipment to evaluate the combined effects of tranquil and pentobarbital. Changes in amount of cerebral 5hydroxytryptamine(5HT) and 5hydroxyindole acetic acid (5HIAA) were observed. The results showed that tranquil could reduce the AA of mice and exert a synergic hypnotic effect with pentobarbital. There was a tendency in decreasing cerebral 5HT and increasing 5HIAA. LC50 value for mice exceeded 70 000 mg/m\+3. In rats exposed to tranquil at 59 066 mg/m\+3, 4 hours every day for 3 consecutive days, Author no respiratory irritative action was observed. This indicated the inhibitory effects of tranquil on the CNS of mice. Its action mechanism is probably different from that of diazepam and may be related to the function of central neurotransmitter 5hydroxytryptamine. Tranquil has low inhalation toxicity and no irritative action on the respiratory tract.\;
