Seventy four cases of infertility were examined to study the hemodynamics of the bilateral ovarian arteries at 21st day during the corpus luteum phase by color Doppler energy(CDE) and color Doppler flow imaging (CDFI...Seventy four cases of infertility were examined to study the hemodynamics of the bilateral ovarian arteries at 21st day during the corpus luteum phase by color Doppler energy(CDE) and color Doppler flow imaging (CDFI). All the patients were verified by laparoscopy, fallopian tube patency examination and ovarian function test. Twenty two healthy women served as controls. The results showed that the difference of resistance index(RI)and pulsatility index (PI) of bilateral ovarian arteries between the infertility and the normal controls had statistical significance ( P <0.01), and the PI showed negative correlation with the thickness of endometrium (left side: r =0.724, P <0.01; right side: r =0.756, P <0.01). The results also showed that CDE was more sensitive than CDFI in displaying the ovarian arteries. It could be concluded that the elevated resistance of ovarian artery during the corpus luteum phase was one of the important factors that resulted in infertility.展开更多
Objective: To study the correlation of body mass index with Th1/Th2 balance, adhesion molecules and insulin signal transduction in infertile patients. Methods: A total of 132 patients who received diagnostic curettage...Objective: To study the correlation of body mass index with Th1/Th2 balance, adhesion molecules and insulin signal transduction in infertile patients. Methods: A total of 132 patients who received diagnostic curettage due to infertility in Tangshan Maternal and Child Health Hospital between June 2015 and March 2016 were selected as the research subjects and divided into the normal group with BMI<25 kg/m2, the overweight group with BMI 25-30 kg/m2 and the obesity group with BMI > 30 kg/m2 according to BMI, and the levels of Th1/Th2 cytokines in serum as well as the expression of Th1/Th2 transcription factors, adhesion molecules and insulin signal pathway molecules in endometrial tissue were detected. Results:IFN-γ and TNF-α levels in serum of obesity group and overweight group were significantly higher than those of control group while IL-4, IL-5 and IL-13 levels in serum as well as CD44V6, N-cadherin, FAK, ICAM-1, GLUT-4, IRS-1, PI3K and AKT mRNA expression in endometrial tissue were significantly lower than those of control group;IFN-γ and TNF-α levels in serum of obesity group were significantly higher than those of overweight group while IL-4, IL-5 and IL-13 levels in serum as well as CD44V6, N-cadherin, FAK, ICAM-1, GLUT-4, IRS-1, PI3K and AKT mRNA expression in endometrial tissue were significantly lower than those of overweight group. Conclusion: Weight gain can aggravate the Th1/Th2 disorder, reduce the adhesion molecule expression and hinder the insulin signal transduction in infertile patients.展开更多
目的观察苍附导痰汤加二甲双胍联合穴位埋线对肥胖型多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕症患者免疫功能及肠道菌群的影响。方法选取肥胖型PCOS不孕症120例,采用随机数字表法随机将其分为观察组和对照组两组各60例,其...目的观察苍附导痰汤加二甲双胍联合穴位埋线对肥胖型多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕症患者免疫功能及肠道菌群的影响。方法选取肥胖型PCOS不孕症120例,采用随机数字表法随机将其分为观察组和对照组两组各60例,其中84例顺利完成研究,观察组40例,对照组44例。观察组采用苍附导痰汤加二甲双胍联合穴位埋线进行治疗,对照组采用苍附导痰汤加二甲双胍进行治疗,均治疗12周。比较两组治疗前后T细胞免疫应答指标、胰岛素抵抗指标和肠道菌群情况,并观察两组治疗期间不良反应发生情况。结果治疗前,两组T细胞免疫应答指标、胰岛素抵抗指标及肠道菌群情况比较差异均无统计学意义(P>0.05)。治疗后,两组血清转化生长因子-β1(TGF-β1)、白细胞介素-10(IL-10)水平及乳酸杆菌、双歧杆菌均较治疗前升高;血清白细胞介素-17(IL-17),空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、空腹胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)水平,以及肠杆菌均较治疗前降低,差异有统计学意义(P<0.01)。治疗后,观察组血清TGF-β1、IL-10水平及乳酸杆菌、双歧杆菌高于对照组;血清IL-17,FBG、2 h PBG、FINS、HOMA-IR水平,以及肠杆菌低于对照组,差异有统计学意义(P<0.01)。治疗期间,观察组出现皮疹5例,因埋线导致皮肤红肿1例;对照组出现皮疹5例。结论苍附导痰汤加二甲双胍联合穴位埋线应用于肥胖型PCOS不孕症可以减少胰岛素抵抗、纠正Treg/Th17失衡、调节T细胞免疫应答、改善肠道微生物稳态失衡,且不良反应较少。展开更多
文摘Seventy four cases of infertility were examined to study the hemodynamics of the bilateral ovarian arteries at 21st day during the corpus luteum phase by color Doppler energy(CDE) and color Doppler flow imaging (CDFI). All the patients were verified by laparoscopy, fallopian tube patency examination and ovarian function test. Twenty two healthy women served as controls. The results showed that the difference of resistance index(RI)and pulsatility index (PI) of bilateral ovarian arteries between the infertility and the normal controls had statistical significance ( P <0.01), and the PI showed negative correlation with the thickness of endometrium (left side: r =0.724, P <0.01; right side: r =0.756, P <0.01). The results also showed that CDE was more sensitive than CDFI in displaying the ovarian arteries. It could be concluded that the elevated resistance of ovarian artery during the corpus luteum phase was one of the important factors that resulted in infertility.
文摘Objective: To study the correlation of body mass index with Th1/Th2 balance, adhesion molecules and insulin signal transduction in infertile patients. Methods: A total of 132 patients who received diagnostic curettage due to infertility in Tangshan Maternal and Child Health Hospital between June 2015 and March 2016 were selected as the research subjects and divided into the normal group with BMI<25 kg/m2, the overweight group with BMI 25-30 kg/m2 and the obesity group with BMI > 30 kg/m2 according to BMI, and the levels of Th1/Th2 cytokines in serum as well as the expression of Th1/Th2 transcription factors, adhesion molecules and insulin signal pathway molecules in endometrial tissue were detected. Results:IFN-γ and TNF-α levels in serum of obesity group and overweight group were significantly higher than those of control group while IL-4, IL-5 and IL-13 levels in serum as well as CD44V6, N-cadherin, FAK, ICAM-1, GLUT-4, IRS-1, PI3K and AKT mRNA expression in endometrial tissue were significantly lower than those of control group;IFN-γ and TNF-α levels in serum of obesity group were significantly higher than those of overweight group while IL-4, IL-5 and IL-13 levels in serum as well as CD44V6, N-cadherin, FAK, ICAM-1, GLUT-4, IRS-1, PI3K and AKT mRNA expression in endometrial tissue were significantly lower than those of overweight group. Conclusion: Weight gain can aggravate the Th1/Th2 disorder, reduce the adhesion molecule expression and hinder the insulin signal transduction in infertile patients.
文摘目的观察苍附导痰汤加二甲双胍联合穴位埋线对肥胖型多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕症患者免疫功能及肠道菌群的影响。方法选取肥胖型PCOS不孕症120例,采用随机数字表法随机将其分为观察组和对照组两组各60例,其中84例顺利完成研究,观察组40例,对照组44例。观察组采用苍附导痰汤加二甲双胍联合穴位埋线进行治疗,对照组采用苍附导痰汤加二甲双胍进行治疗,均治疗12周。比较两组治疗前后T细胞免疫应答指标、胰岛素抵抗指标和肠道菌群情况,并观察两组治疗期间不良反应发生情况。结果治疗前,两组T细胞免疫应答指标、胰岛素抵抗指标及肠道菌群情况比较差异均无统计学意义(P>0.05)。治疗后,两组血清转化生长因子-β1(TGF-β1)、白细胞介素-10(IL-10)水平及乳酸杆菌、双歧杆菌均较治疗前升高;血清白细胞介素-17(IL-17),空腹血糖(FBG)、餐后2 h血糖(2 h PBG)、空腹胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)水平,以及肠杆菌均较治疗前降低,差异有统计学意义(P<0.01)。治疗后,观察组血清TGF-β1、IL-10水平及乳酸杆菌、双歧杆菌高于对照组;血清IL-17,FBG、2 h PBG、FINS、HOMA-IR水平,以及肠杆菌低于对照组,差异有统计学意义(P<0.01)。治疗期间,观察组出现皮疹5例,因埋线导致皮肤红肿1例;对照组出现皮疹5例。结论苍附导痰汤加二甲双胍联合穴位埋线应用于肥胖型PCOS不孕症可以减少胰岛素抵抗、纠正Treg/Th17失衡、调节T细胞免疫应答、改善肠道微生物稳态失衡,且不良反应较少。
