目的观察结肠癌患者乙肝病毒感染状态及表面抗原/抗体水平,分析其与结肠癌分期的关联,从而间接评估结肠癌患者合并乙型肝炎对其预后的影响。方法收集福建省立医院收治的85例结肠癌患者,采用SPSS16.0统计软件回顾性分析乙肝病毒感染状态...目的观察结肠癌患者乙肝病毒感染状态及表面抗原/抗体水平,分析其与结肠癌分期的关联,从而间接评估结肠癌患者合并乙型肝炎对其预后的影响。方法收集福建省立医院收治的85例结肠癌患者,采用SPSS16.0统计软件回顾性分析乙肝病毒感染状态对结肠癌浸润深度、区域淋巴结转移和远处转移的影响。结果乙肝病毒感染状态对结肠癌原发灶浸润深度(T)(P=0.331)和结肠癌区域淋巴结转移(N)的影响差异无统计学意义(P=0.098)。合并乙肝病毒阳性的结肠癌患者其区域淋巴结转移度明显低于乙肝病毒阴性的亚组(8.1%vs.17.8%),且无区域淋巴结转移的结肠癌患者血清中Hbs Ab水平较发生淋巴结转移的亚组患者明显升高(240.111 m IU/ml vs.178.161 m IU/ml)。乙肝病毒感染状态对结肠癌患者发生远处转移(M)以及肝转移的影响差异均具有统计学意义(均P<0.001)。不论是乙肝病毒感染还是乙肝疫苗相关的乙肝病毒阳性患者,肝转移发生率均显著低于乙肝病毒阴性的患者(P=0.039,P<0.001)。结论结肠癌合并乙肝病毒表面抗体水平高表达对区域淋巴结转移可能具有潜在的抑制作用。乙肝病毒阳性对结肠癌发生远处转移(尤其对肝转移)呈显著性负相关。乙肝病毒感染状态以及表面抗原/抗体水平显著性影响结肠癌患者的分期及预后。展开更多
The mesenteric lymph node cavitation syndrome consists of central necrosis of mesenteric lymph nodes and may occur with either celiac disease or a sprue-like intestinal disease that fails to respond to a gluten-free d...The mesenteric lymph node cavitation syndrome consists of central necrosis of mesenteric lymph nodes and may occur with either celiac disease or a sprue-like intestinal disease that fails to respond to a gluten-free diet. Splenic hypofunction may also be present. The cause is not known but its development during the clinical course of celiac disease is usually indicative of a poor prognosis for the intestinal disorder, a potential for signif icant compli-cations including sepsis and malignancy, particularly T-cell lymphoma, and signif icant mortality. Modern abdominal imaging modalities may permit earlier detection in celiac disease so that earlier diagnosis and improved under-standing of its pathogenesis may result.展开更多
Background: Inguinal lymph node dissections (ILND) have been commonly associated with postoperative complications such as lymphedema, lymph fistula and wound infections. The reported complication rates after ILND rang...Background: Inguinal lymph node dissections (ILND) have been commonly associated with postoperative complications such as lymphedema, lymph fistula and wound infections. The reported complication rates after ILND range from 14% - 77%, and a rationale for these large differences is the use of a variety of different definitions of complications. Patients and Methods: Files of patients that underwent inguinal lymph node dissection for lymph node metastases at the Department of General and Visceral Surgery of the University Hospital Frankfurt between February 2005 and March 2012 were retrospectively reviewed. Results: 47 patients (65%) developed a lymphatic fistula in the course of the operation, of which 6 patients (8%) underwent reoperations. Surgical side infections (SSI) were seen in 15 patients (21%), all of them harbouring fistulas. Patients presenting with a BMI ≥ 30 kg/m2 did not develop more fistulas than those with a BMI 2 (p = 0.30). Patients who suffered from a lymph fistula had significantly more visits in the outpatient clinic (p =< 0.0001). There was no difference in the complication rate if the procedure was performed by a resident under supervision or a senior surgeon (p = 0.79). Conclusion: In this study, we demonstrated that lymph fistulas are to date a common complication after ILND and lead to reoperations and significantly more outpatient visits. The number of lymph nodes affected and resected, and prior sentinel lymph node dissection, was not associated with a higher complication rate.展开更多
文摘目的观察结肠癌患者乙肝病毒感染状态及表面抗原/抗体水平,分析其与结肠癌分期的关联,从而间接评估结肠癌患者合并乙型肝炎对其预后的影响。方法收集福建省立医院收治的85例结肠癌患者,采用SPSS16.0统计软件回顾性分析乙肝病毒感染状态对结肠癌浸润深度、区域淋巴结转移和远处转移的影响。结果乙肝病毒感染状态对结肠癌原发灶浸润深度(T)(P=0.331)和结肠癌区域淋巴结转移(N)的影响差异无统计学意义(P=0.098)。合并乙肝病毒阳性的结肠癌患者其区域淋巴结转移度明显低于乙肝病毒阴性的亚组(8.1%vs.17.8%),且无区域淋巴结转移的结肠癌患者血清中Hbs Ab水平较发生淋巴结转移的亚组患者明显升高(240.111 m IU/ml vs.178.161 m IU/ml)。乙肝病毒感染状态对结肠癌患者发生远处转移(M)以及肝转移的影响差异均具有统计学意义(均P<0.001)。不论是乙肝病毒感染还是乙肝疫苗相关的乙肝病毒阳性患者,肝转移发生率均显著低于乙肝病毒阴性的患者(P=0.039,P<0.001)。结论结肠癌合并乙肝病毒表面抗体水平高表达对区域淋巴结转移可能具有潜在的抑制作用。乙肝病毒阳性对结肠癌发生远处转移(尤其对肝转移)呈显著性负相关。乙肝病毒感染状态以及表面抗原/抗体水平显著性影响结肠癌患者的分期及预后。
文摘The mesenteric lymph node cavitation syndrome consists of central necrosis of mesenteric lymph nodes and may occur with either celiac disease or a sprue-like intestinal disease that fails to respond to a gluten-free diet. Splenic hypofunction may also be present. The cause is not known but its development during the clinical course of celiac disease is usually indicative of a poor prognosis for the intestinal disorder, a potential for signif icant compli-cations including sepsis and malignancy, particularly T-cell lymphoma, and signif icant mortality. Modern abdominal imaging modalities may permit earlier detection in celiac disease so that earlier diagnosis and improved under-standing of its pathogenesis may result.
文摘Background: Inguinal lymph node dissections (ILND) have been commonly associated with postoperative complications such as lymphedema, lymph fistula and wound infections. The reported complication rates after ILND range from 14% - 77%, and a rationale for these large differences is the use of a variety of different definitions of complications. Patients and Methods: Files of patients that underwent inguinal lymph node dissection for lymph node metastases at the Department of General and Visceral Surgery of the University Hospital Frankfurt between February 2005 and March 2012 were retrospectively reviewed. Results: 47 patients (65%) developed a lymphatic fistula in the course of the operation, of which 6 patients (8%) underwent reoperations. Surgical side infections (SSI) were seen in 15 patients (21%), all of them harbouring fistulas. Patients presenting with a BMI ≥ 30 kg/m2 did not develop more fistulas than those with a BMI 2 (p = 0.30). Patients who suffered from a lymph fistula had significantly more visits in the outpatient clinic (p =< 0.0001). There was no difference in the complication rate if the procedure was performed by a resident under supervision or a senior surgeon (p = 0.79). Conclusion: In this study, we demonstrated that lymph fistulas are to date a common complication after ILND and lead to reoperations and significantly more outpatient visits. The number of lymph nodes affected and resected, and prior sentinel lymph node dissection, was not associated with a higher complication rate.
