Controlling the vapor-deposited nanoribbons to grow along a consistent orientation will enable the desired in situ integration of functional devices,representing a major technological advance compared to post-growth p...Controlling the vapor-deposited nanoribbons to grow along a consistent orientation will enable the desired in situ integration of functional devices,representing a major technological advance compared to post-growth processing strategies.In this work,ntype F_(16)CuPc molecules are self-assembled into horizontally-oriented nanoribbons with a consistent growth axis after creating periodic hydrophobic nanogrooves on a sapphire surface.Consequently,electrodes are deposited directly on the growth substrate to enable in situ fabrication of photodetectors.Depending on the deposited electrodes,these horizontally-oriented nanoribbons are connected to form a monolithic photodetector with a large sensing area or an on-chip array of photodetectors with multiple detector units.This in situ integration strategy avoids potential structural damage and contamination from impurities associated with post-growth processing steps.Therefore,the vapor-deposited nanoribbons can retain their high quality during the device manufacturing process,which contributes to performance improvement.As a result,the in-situ integrated F_(16)CuPc photodetectors exhibit a sensitive response in the ultraviolet-visible-near-infrared(UV-vis-NIR)region.The response time is on the order of tens of milliseconds,the fastest record ever for the F_(16)CuPc-based photodetectors.Furthermore,statistics from an array of 6×6 photodetectors show little variation in their sensitivity and response time,and hence this in situ fabrication scheme will contribute to the implementation of on-chip integrated photodetectors with consistent performance based on bottom-up nanoribbons.Overall,this self-oriented growth provides a versatile option to achieve desired in-situ integrated functional devices based on bottom-up nanoribbons.展开更多
Disaster management and in particular disaster response phase are highly timesensitive and dynamic processes,demanding that real-time information reaches disaster responders prior making critical decisions.During the ...Disaster management and in particular disaster response phase are highly timesensitive and dynamic processes,demanding that real-time information reaches disaster responders prior making critical decisions.During the last decade,disaster management has been widely enabled through utilizing spatial data sourcing and related technologies in the whole process of collection,access,and usage of disaster information.Currently,there are unique challenges that cannot be met without incorporating in situ sensing as an emerging technology for sourcing and managing disaster information.These include(1)high temporal and spatial resolution of information,(2)broad range of disaster data,and(3)automated operations.Incorporating in situ sensing into the disaster management process can potentially address such challenges by providing data that support all of these requirements.Following an examination of current concepts and methods for integrating multisourced sensors,a framework of the requirements for integrating in situ sensors for disaster management,is suggested.Based on this framework and its components,an evaluation of the methods is developed and applied.The results highlight that information integration of multisourced sensors is a major challenge and has not yet adequately addressed for sensor data enablement of disaster management.展开更多
Aim: To study the integration of hepatitis B virus (HBV) DNA into sperm chromosomes in hepatitis B patients and the features of its integration. Methods: Sperm chromosomes of 14 subjects (5 healthy controls and 9 HB p...Aim: To study the integration of hepatitis B virus (HBV) DNA into sperm chromosomes in hepatitis B patients and the features of its integration. Methods: Sperm chromosomes of 14 subjects (5 healthy controls and 9 HB patients, including 1 acute hepatitis B, 2 chronic active hepatitis B, 4 chronic persistent hepatitis B, 2 HBsAg chronic carriers with no clinical symptoms) were prepared using interspecific in vitro fertilization between zona-free hamster oocytes and human spermatozoa. Fluorescence in situ hybridization (FISH) to sperm chromosome spreads was carried out with biotin-labeled full length HBV DNA probe to detect the specific HBV DNA sequences in the sperm chromosomes. Results: Specific fluorescent signal spots for HBV DNA were seen in sperm chromosomes of one patient with chronic persistent hepatitis B. In 9(9/42) sperm chromosome complements containing fluorescent signal spots, one presented 5 obvious FISH spots and the others 2 to 4 signals. The fluorescence intensity showed significant difference among the signal spots. The distribution of signal sites among chromosomes seems to be random. Conclusion: HBV could integrate into human sperm chromosomes. Results suggest that the possibility of vertical transmission of HBV via the germ line to the next generation is present.展开更多
基金The authors acknowledge the financial support by the 2019QN01C290Guangdong Basic and Applied Basic Research Foundation(No.2021A1515012235)+1 种基金the Outstanding Young Scholar at South China Normal University,Science and Technology Program of Guangzhou(No.2019050001)Guangdong Provincial Key Laboratory of Optical Information Materials and Technology(No.2017B030301007).
文摘Controlling the vapor-deposited nanoribbons to grow along a consistent orientation will enable the desired in situ integration of functional devices,representing a major technological advance compared to post-growth processing strategies.In this work,ntype F_(16)CuPc molecules are self-assembled into horizontally-oriented nanoribbons with a consistent growth axis after creating periodic hydrophobic nanogrooves on a sapphire surface.Consequently,electrodes are deposited directly on the growth substrate to enable in situ fabrication of photodetectors.Depending on the deposited electrodes,these horizontally-oriented nanoribbons are connected to form a monolithic photodetector with a large sensing area or an on-chip array of photodetectors with multiple detector units.This in situ integration strategy avoids potential structural damage and contamination from impurities associated with post-growth processing steps.Therefore,the vapor-deposited nanoribbons can retain their high quality during the device manufacturing process,which contributes to performance improvement.As a result,the in-situ integrated F_(16)CuPc photodetectors exhibit a sensitive response in the ultraviolet-visible-near-infrared(UV-vis-NIR)region.The response time is on the order of tens of milliseconds,the fastest record ever for the F_(16)CuPc-based photodetectors.Furthermore,statistics from an array of 6×6 photodetectors show little variation in their sensitivity and response time,and hence this in situ fabrication scheme will contribute to the implementation of on-chip integrated photodetectors with consistent performance based on bottom-up nanoribbons.Overall,this self-oriented growth provides a versatile option to achieve desired in-situ integrated functional devices based on bottom-up nanoribbons.
基金This research project has been supported as a part of‘An Intelligent Disaster Decision Support System for urban disaster’funded by Australian Natural Disaster Resilience Grant Scheme in collaboration with the CSDILA,Department of Infrastructure Engineering,the University of Melbourne.
文摘Disaster management and in particular disaster response phase are highly timesensitive and dynamic processes,demanding that real-time information reaches disaster responders prior making critical decisions.During the last decade,disaster management has been widely enabled through utilizing spatial data sourcing and related technologies in the whole process of collection,access,and usage of disaster information.Currently,there are unique challenges that cannot be met without incorporating in situ sensing as an emerging technology for sourcing and managing disaster information.These include(1)high temporal and spatial resolution of information,(2)broad range of disaster data,and(3)automated operations.Incorporating in situ sensing into the disaster management process can potentially address such challenges by providing data that support all of these requirements.Following an examination of current concepts and methods for integrating multisourced sensors,a framework of the requirements for integrating in situ sensors for disaster management,is suggested.Based on this framework and its components,an evaluation of the methods is developed and applied.The results highlight that information integration of multisourced sensors is a major challenge and has not yet adequately addressed for sensor data enablement of disaster management.
文摘Aim: To study the integration of hepatitis B virus (HBV) DNA into sperm chromosomes in hepatitis B patients and the features of its integration. Methods: Sperm chromosomes of 14 subjects (5 healthy controls and 9 HB patients, including 1 acute hepatitis B, 2 chronic active hepatitis B, 4 chronic persistent hepatitis B, 2 HBsAg chronic carriers with no clinical symptoms) were prepared using interspecific in vitro fertilization between zona-free hamster oocytes and human spermatozoa. Fluorescence in situ hybridization (FISH) to sperm chromosome spreads was carried out with biotin-labeled full length HBV DNA probe to detect the specific HBV DNA sequences in the sperm chromosomes. Results: Specific fluorescent signal spots for HBV DNA were seen in sperm chromosomes of one patient with chronic persistent hepatitis B. In 9(9/42) sperm chromosome complements containing fluorescent signal spots, one presented 5 obvious FISH spots and the others 2 to 4 signals. The fluorescence intensity showed significant difference among the signal spots. The distribution of signal sites among chromosomes seems to be random. Conclusion: HBV could integrate into human sperm chromosomes. Results suggest that the possibility of vertical transmission of HBV via the germ line to the next generation is present.
