AIM:To describe the cardiovascular disease(CVD)risk factors in a population of children with celiac disease(CD)on a gluten-free diet(GFD).METHODS:This cross-sectional multicenter study was performed at Schneider Child...AIM:To describe the cardiovascular disease(CVD)risk factors in a population of children with celiac disease(CD)on a gluten-free diet(GFD).METHODS:This cross-sectional multicenter study was performed at Schneider Children’s Medical Center of Israel(Petach Tiqva,Israel),and San Paolo Hospital(Milan,Italy).We enrolled 114 CD children in serologic remission,who were on a GFD for at least one year.At enrollment,anthropometric measurements,blood lipids and glucose were assessed,and compared to values at diagnosis.The homeostasis model assessment-estimated insulin resistance was calculated as a measure of insulin resistance.RESULTS:Three or more concomitant CVD risk factors[body mass index,waist circumference,low density lipoprotein(LDL)cholesterol,triglycerides,blood pressure and insulin resistance]were identified in 14%of CD subjects on a GFD.The most common CVD risk factors were high fasting triglycerides(34.8%),elevated blood pressure(29.4%),and high concentrations of calculated LDL cholesterol(24.1%).On a GFD,four children(3.5%)had insulin resistance.Fasting insulin and HOMA-IR were significantly higher in the Italian cohort compared to the Israeli cohort(P<0.001).Children on a GFD had an increased prevalence of borderline LDL cholesterol(24%)when compared to values(10%)at diagnosis(P=0.090).Trends towards increases in overweight(from 8.8%to 11.5%)and obesity(from 5.3%to 8.8%)were seen on a GFD.CONCLUSION:This report of insulin resistance and CVD risk factors in celiac children highlights the importance of CVD screening,and the need for dietary counseling targeting CVD prevention.展开更多
目的了解社区综合干预措施对控制小儿高脂血症效果,探讨完善小儿高脂血症的社区综合干预模式。方法对社区内127例小儿高脂血症儿童采用饮食、运动、健康教育措施进行综合干预治疗,观察干预前后效果,并同时检测干预前后身高、体重、体质...目的了解社区综合干预措施对控制小儿高脂血症效果,探讨完善小儿高脂血症的社区综合干预模式。方法对社区内127例小儿高脂血症儿童采用饮食、运动、健康教育措施进行综合干预治疗,观察干预前后效果,并同时检测干预前后身高、体重、体质指数(body mass index,BMI)指数、血色素、微量元素变化情况,以了解患儿生长发育情况。结果干预后患儿血脂水平指标均有改善,差异均有统计学意义(P<0.05);身高、体重、血色素、微量元素水平指标差异均无统计学意义(P>0.05)。结论社区综合干预对治疗和控制小儿高脂血症有重要作用,对患儿生长发育无影响。展开更多
文摘AIM:To describe the cardiovascular disease(CVD)risk factors in a population of children with celiac disease(CD)on a gluten-free diet(GFD).METHODS:This cross-sectional multicenter study was performed at Schneider Children’s Medical Center of Israel(Petach Tiqva,Israel),and San Paolo Hospital(Milan,Italy).We enrolled 114 CD children in serologic remission,who were on a GFD for at least one year.At enrollment,anthropometric measurements,blood lipids and glucose were assessed,and compared to values at diagnosis.The homeostasis model assessment-estimated insulin resistance was calculated as a measure of insulin resistance.RESULTS:Three or more concomitant CVD risk factors[body mass index,waist circumference,low density lipoprotein(LDL)cholesterol,triglycerides,blood pressure and insulin resistance]were identified in 14%of CD subjects on a GFD.The most common CVD risk factors were high fasting triglycerides(34.8%),elevated blood pressure(29.4%),and high concentrations of calculated LDL cholesterol(24.1%).On a GFD,four children(3.5%)had insulin resistance.Fasting insulin and HOMA-IR were significantly higher in the Italian cohort compared to the Israeli cohort(P<0.001).Children on a GFD had an increased prevalence of borderline LDL cholesterol(24%)when compared to values(10%)at diagnosis(P=0.090).Trends towards increases in overweight(from 8.8%to 11.5%)and obesity(from 5.3%to 8.8%)were seen on a GFD.CONCLUSION:This report of insulin resistance and CVD risk factors in celiac children highlights the importance of CVD screening,and the need for dietary counseling targeting CVD prevention.
文摘目的了解社区综合干预措施对控制小儿高脂血症效果,探讨完善小儿高脂血症的社区综合干预模式。方法对社区内127例小儿高脂血症儿童采用饮食、运动、健康教育措施进行综合干预治疗,观察干预前后效果,并同时检测干预前后身高、体重、体质指数(body mass index,BMI)指数、血色素、微量元素变化情况,以了解患儿生长发育情况。结果干预后患儿血脂水平指标均有改善,差异均有统计学意义(P<0.05);身高、体重、血色素、微量元素水平指标差异均无统计学意义(P>0.05)。结论社区综合干预对治疗和控制小儿高脂血症有重要作用,对患儿生长发育无影响。
