Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub-and outercoating combined with enteric aqueous coating. The main aim was to inv...Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub-and outercoating combined with enteric aqueous coating. The main aim was to investigate the influence of these factors on the stability of ASA and understand how they work. Satisfactory storage stability were obtained when the aspirin tablet core coated with Eudragit L30D55 film was combined with glycerin monostearate(GMS) as an outercoat. Hygroscopicity testing indicated that the moisture penetrating into the tablet may result in a significant change in the physical properties of the coating film observed by scanning electron microscopy. Investigation of the compatibility between the drug and film excipients shows that the talc and methacrylic acid had a significant catalytic effect on ASA. A hypothesis was proposed that the hydrolysis of ASA enteric coated tablets(ASA-ECT) was mostly concentrated in the internal film and the interfaces between the film and tablet core. In conclusion, hot-melt coating technology is an alternative to subcoating or outercoating. Also, GMS sub-coating was a better choice for forming a stable barrier between the tablet core and the polymer coating layer, and increases the structure and chemical stability.展开更多
As the developing of the traffic and transport, road signs coating materials become important more and more. This paper introduces the development and current situation of the traffic marking coating and discusses its...As the developing of the traffic and transport, road signs coating materials become important more and more. This paper introduces the development and current situation of the traffic marking coating and discusses its raw material and application operation. C 5 petroleum resin made in china is used as major material in a hot melt traffic marking coating. To get the best material composition, orthogonal test is used and wear resistant, water resistant, acidity proof, alkaline proof, adhesive strength, fluid characteristic of the coating is researched.展开更多
基金supported by the National Natural Science Foundation of China(No.81402858)the Liaoning Natural Science Foundation(No.2015020736)Shenyang Pharmaceutical University Long-term Training Fund(No.ZCJJ2014406)
文摘Aspirin is apt to hydrolyze. In order to improve its stability, a new method has been developed involving the application of hot-melt sub-and outercoating combined with enteric aqueous coating. The main aim was to investigate the influence of these factors on the stability of ASA and understand how they work. Satisfactory storage stability were obtained when the aspirin tablet core coated with Eudragit L30D55 film was combined with glycerin monostearate(GMS) as an outercoat. Hygroscopicity testing indicated that the moisture penetrating into the tablet may result in a significant change in the physical properties of the coating film observed by scanning electron microscopy. Investigation of the compatibility between the drug and film excipients shows that the talc and methacrylic acid had a significant catalytic effect on ASA. A hypothesis was proposed that the hydrolysis of ASA enteric coated tablets(ASA-ECT) was mostly concentrated in the internal film and the interfaces between the film and tablet core. In conclusion, hot-melt coating technology is an alternative to subcoating or outercoating. Also, GMS sub-coating was a better choice for forming a stable barrier between the tablet core and the polymer coating layer, and increases the structure and chemical stability.
文摘As the developing of the traffic and transport, road signs coating materials become important more and more. This paper introduces the development and current situation of the traffic marking coating and discusses its raw material and application operation. C 5 petroleum resin made in china is used as major material in a hot melt traffic marking coating. To get the best material composition, orthogonal test is used and wear resistant, water resistant, acidity proof, alkaline proof, adhesive strength, fluid characteristic of the coating is researched.
