IN 1984, Gehring and Scoff discovered homeobox genes respectively and confirmed that the homeobox genes were the control genes of the constructure genes in biological development, which was a breakthrough in molecular...IN 1984, Gehring and Scoff discovered homeobox genes respectively and confirmed that the homeobox genes were the control genes of the constructure genes in biological development, which was a breakthrough in molecular development biology. It is important for embryo development and evolution to further study the homeobox genes, including gene mapping. Recently, the reseach on the homeobox gene mapping has drawn much attention, but mostly展开更多
Schizophrenia(SCZ)is the most common serious mental illness with a high disability rate and heavy social and family burdens.At present,there is no clear etiology and pathogenesis of schizophrenia.Studies have shown th...Schizophrenia(SCZ)is the most common serious mental illness with a high disability rate and heavy social and family burdens.At present,there is no clear etiology and pathogenesis of schizophrenia.Studies have shown that the occurrence of schizophrenia may be related to the abnormality of the hypothalamic-pituitary-adrenal(HPA)axis.The LIM-homeobox gene 3(LHXS)and early growth response 1(EGR1)can affect pituitary function.Because the synapsin 2(SYN2)gene polymorphism regulates the activity of LHX3 and EGR1,it may cause the occurrence of schizophrenia.This article will review the possible involvement of SYN2 gene polymorphism in the pathogenesis of schizophrenia via regulating the activity of LHX3 and EGR1,then to afiect the HPA axis.展开更多
文摘IN 1984, Gehring and Scoff discovered homeobox genes respectively and confirmed that the homeobox genes were the control genes of the constructure genes in biological development, which was a breakthrough in molecular development biology. It is important for embryo development and evolution to further study the homeobox genes, including gene mapping. Recently, the reseach on the homeobox gene mapping has drawn much attention, but mostly
基金Yunnan Provincial Department of Science and Technology Project(202101AY070001-224).
文摘Schizophrenia(SCZ)is the most common serious mental illness with a high disability rate and heavy social and family burdens.At present,there is no clear etiology and pathogenesis of schizophrenia.Studies have shown that the occurrence of schizophrenia may be related to the abnormality of the hypothalamic-pituitary-adrenal(HPA)axis.The LIM-homeobox gene 3(LHXS)and early growth response 1(EGR1)can affect pituitary function.Because the synapsin 2(SYN2)gene polymorphism regulates the activity of LHX3 and EGR1,it may cause the occurrence of schizophrenia.This article will review the possible involvement of SYN2 gene polymorphism in the pathogenesis of schizophrenia via regulating the activity of LHX3 and EGR1,then to afiect the HPA axis.
