Objective:To evaluate the lipid-regulating effect of crude-herb moxibustion on rats with dyslipidemia.Methods:Fifty-four SpragueeDawley rats were randomly divided into six groups with nine rats each.Control group rats...Objective:To evaluate the lipid-regulating effect of crude-herb moxibustion on rats with dyslipidemia.Methods:Fifty-four SpragueeDawley rats were randomly divided into six groups with nine rats each.Control group rats were fed a normal diet,and bilateral acu-point Fenglong(equivalent to ST40 in humans)on the hind legs were covered with a placebo(general mucilage)for 2 hours each day.Model group rats were fed a high-lipid diet for 2 weeks.Therapy group rats were fed a high-lipid diet for 2 weeks and then administered crude-herb moxibustion at ST40 for 2 hours each day for the next 2 weeks.Prevention group rats were administered crude-herb moxibustion 2 hours a day for 2 weeks and then fed a high-lipid diet for the subsequent 2 weeks.Prevention/Therapy group rats were each administered crude-herb moxibustion at ST40 for 2 hours each day for 2 weeks,followed by a high-lipid diet for the next 2 weeks,and then crude-herb moxibustion again at ST40 for another 2 weeks.Simvastatin group rats were fed a high-lipid diet for 2 weeks and then treated with simvastatin for the next 2 weeks.Blood lipids,hepatosomatic indices(HSIs)and epididymal fat pad weights of all rats were examined.Results:Compared with the Model group,levels of total cholesterol(TC),glycerinate,lowdensity lipoprotein cholesterol(LDL-C)and very low-density lipoprotein cholesterol(VLDL-C)in plasma collected from the Therapy group,the Prevention/Therapy group,and the Simvastatin group were decreased.Moreover,compared with the Model group,HSIs in Therapy group rats were also decreased following administration of crude-herb moxibustion,but TC,TG,HDLC,LDL-C,and VLDL-C levels in the Prevention group were higher than those in the Model group.Conclusion:The results reveal that blood lipids and HSIs appear to be modulated by the effect of crude-herb moxibustion and suggest therapeutic strategies for the treatment of dyslipidemia.展开更多
OBJECTIVE: To determine the effect of hypercholsterolemia induced by a high-lipid diet on glomerulosclerosis. METHODS: Twenty nephrotic syndrome (NS) Wistar rats administrated adriamycin (ADR) with a single intravenou...OBJECTIVE: To determine the effect of hypercholsterolemia induced by a high-lipid diet on glomerulosclerosis. METHODS: Twenty nephrotic syndrome (NS) Wistar rats administrated adriamycin (ADR) with a single intravenous dose of 5 mg/kg body weight, were divided into the standard and high-lipid chow groups. Another 20 weight-matched non-NS rats that received a vehicle alone were grouped as control. Urinary protein excretion and serum cholesterol were assayed; image analysis and techniques of pathology, immunohistochemistry, and molecular biology were used to determine morphological changes in glomeruli and the production of glomerular mesangial matrices in different groups. RESULTS: The serum total cholesterol level was significantly higher in rats with high-lipid chow in both non-NS [(2.2 +/- 0.3) g/L vs. (0.9 +/- 0.1) g/L, P展开更多
基金the Ministry of Education of the People’s Republic of China(NO:201210026044)supervised by Beijing University of Chinese Medicine.
文摘Objective:To evaluate the lipid-regulating effect of crude-herb moxibustion on rats with dyslipidemia.Methods:Fifty-four SpragueeDawley rats were randomly divided into six groups with nine rats each.Control group rats were fed a normal diet,and bilateral acu-point Fenglong(equivalent to ST40 in humans)on the hind legs were covered with a placebo(general mucilage)for 2 hours each day.Model group rats were fed a high-lipid diet for 2 weeks.Therapy group rats were fed a high-lipid diet for 2 weeks and then administered crude-herb moxibustion at ST40 for 2 hours each day for the next 2 weeks.Prevention group rats were administered crude-herb moxibustion 2 hours a day for 2 weeks and then fed a high-lipid diet for the subsequent 2 weeks.Prevention/Therapy group rats were each administered crude-herb moxibustion at ST40 for 2 hours each day for 2 weeks,followed by a high-lipid diet for the next 2 weeks,and then crude-herb moxibustion again at ST40 for another 2 weeks.Simvastatin group rats were fed a high-lipid diet for 2 weeks and then treated with simvastatin for the next 2 weeks.Blood lipids,hepatosomatic indices(HSIs)and epididymal fat pad weights of all rats were examined.Results:Compared with the Model group,levels of total cholesterol(TC),glycerinate,lowdensity lipoprotein cholesterol(LDL-C)and very low-density lipoprotein cholesterol(VLDL-C)in plasma collected from the Therapy group,the Prevention/Therapy group,and the Simvastatin group were decreased.Moreover,compared with the Model group,HSIs in Therapy group rats were also decreased following administration of crude-herb moxibustion,but TC,TG,HDLC,LDL-C,and VLDL-C levels in the Prevention group were higher than those in the Model group.Conclusion:The results reveal that blood lipids and HSIs appear to be modulated by the effect of crude-herb moxibustion and suggest therapeutic strategies for the treatment of dyslipidemia.
文摘OBJECTIVE: To determine the effect of hypercholsterolemia induced by a high-lipid diet on glomerulosclerosis. METHODS: Twenty nephrotic syndrome (NS) Wistar rats administrated adriamycin (ADR) with a single intravenous dose of 5 mg/kg body weight, were divided into the standard and high-lipid chow groups. Another 20 weight-matched non-NS rats that received a vehicle alone were grouped as control. Urinary protein excretion and serum cholesterol were assayed; image analysis and techniques of pathology, immunohistochemistry, and molecular biology were used to determine morphological changes in glomeruli and the production of glomerular mesangial matrices in different groups. RESULTS: The serum total cholesterol level was significantly higher in rats with high-lipid chow in both non-NS [(2.2 +/- 0.3) g/L vs. (0.9 +/- 0.1) g/L, P
