Presently,liquid crystal displays(LCDs)and organic light-emitting diode(OLED)displays are two dominant flat panel display technologies.Recently,inorganic mini-LEDs(mLEDs)and micro-LEDs(μLEDs)have emerged by significa...Presently,liquid crystal displays(LCDs)and organic light-emitting diode(OLED)displays are two dominant flat panel display technologies.Recently,inorganic mini-LEDs(mLEDs)and micro-LEDs(μLEDs)have emerged by significantly enhancing the dynamic range of LCDs or as sunlight readable emissive displays.“mLED,OLED,orμLED:who wins?”is a heated debatable question.In this review,we conduct a comprehensive analysis on the material properties,device structures,and performance of mLED/μLED/OLED emissive displays and mLED backlit LCDs.We evaluate the power consumption and ambient contrast ratio of each display in depth and systematically compare the motion picture response time,dynamic range,and adaptability to flexible/transparent displays.The pros and cons of mLED,OLED,andμLED displays are analysed,and their future perspectives are discussed.展开更多
Thermally sprayed coatings are essentially layered materials and contain large numbers of lamellar pores. It is thus quite necessary to clarify the formation mechanism of lamellar pores which significantly influence c...Thermally sprayed coatings are essentially layered materials and contain large numbers of lamellar pores. It is thus quite necessary to clarify the formation mechanism of lamellar pores which significantly influence coating performances. In the present study, to elaborate the formation mechanism of lamellar pores, the yttria-stabilized zirconia(ZrO_2–7 wt% Y_2O_3, 7YSZ) splats, which have high fracture toughness and tetragonal phase stability, were employed. Interestingly, anomalous epitaxial growth occurred for all deposition temperatures in spite of the extremely high cooling rate,which clearly indicated chemical bonding and complete contact at splat/substrate interface before splat cooling. However, transverse spallation substantially occurred for all deposition temperatures in spite of the high fracture toughness of 7YSZ, which revealed that the lamellar pores were from transverse cracking/spallation due to the large stress during splat cooling. Additionally, fracture mechanics analysis was carried out, and it was found that the stress arose from the constraint effect of the shrinkage of the splat by locally heated substrate with the value about 1.97 GPa. This clearly demonstrated that the stress was indeed large enough to drive transverse cracking/spallation forming lamellar pores during splat cooling. All of these contribute to understanding the essential features of lamellar bonding and further tailoring the coating structures and performance.展开更多
An experimental system of flat plate pulsating heat pipe was established and experimental research was carried out in this system to know the mechanism of heat transfer, start-up and operating characteristics. The fac...An experimental system of flat plate pulsating heat pipe was established and experimental research was carried out in this system to know the mechanism of heat transfer, start-up and operating characteristics. The factors, such as filling rate, heating power, heating method etc, which have great influence on the thermal performance of the plate pulsating heat pipe were discussed. The results indicate that heating power and filling rate are the important factors for the start-up of the plate pulsating heat pipe. The different start-up power is needed with different filling rate, and the start-up of the heat pipe in case of bottom heated is much easier than that of top heated. Increasing the heating power and enlarging the heating area can make the start-up easier. Heating power can also affect the start-up time of heat pipe under the condition of bottom heated, while it does not have some influence to the heat pipe of top heated. The thermal resistance of plate pulsating heat pipe is related with the heating power, and the higher the heating power is, the smaller the thermal resistance is. But the best filling rate which the heat pipe needs is different with different heating methods, and the performance of the heat pipe in the case of bottom heated is better than the others.展开更多
Moisture content is a fundamental physical index that quantifies soil property and is closely associatedwith the hydrological, ecological and engineering behaviors of soil. To measure in-situ soil moisturecontents, a ...Moisture content is a fundamental physical index that quantifies soil property and is closely associatedwith the hydrological, ecological and engineering behaviors of soil. To measure in-situ soil moisturecontents, a distributed measurement system for in-situ soil moisture content （SM-DTS） is introduced.The system is based on carbon-fiber heated cable （CFHC） technology that has been developed to enhancethe measuring accuracy of in-situ soil moisture content. Using CFHC technique, a temperature characteristicvalue （Tt） can be defined from temperatureetime curves. A relationship among Tt, soil thermalimpedance coefficient and soil moisture content is then established in laboratory. The feasibility of theSM-DTS technology to provide distributed measurements of in-situ soil moisture content is verifiedthrough field tests. The research reported herein indicates that the proposed SM-DTS is capable ofmeasuring in-situ soil moisture content over long distances and large areas.展开更多
Distributed temperature sensing(DTS)using heated cables has been recently developed for distributed monitoring of in-situ soil moisture content.In this method,the thermal and electrical properties of heated cables hav...Distributed temperature sensing(DTS)using heated cables has been recently developed for distributed monitoring of in-situ soil moisture content.In this method,the thermal and electrical properties of heated cables have a significant influence on the measurement accuracy of soil moisture content.In this paper,the performances of two heated cables,i.e.the carbon-fiber heated cable(CFHC)and the metalnet heated cable(MNHC),are studied in the laboratory.Their structures,uniformity in the axial direction,measurement accuracy and suitability are evaluated.The test results indicate that the MNHC has a better uniformity in the axial direction than CFHC.Both CFHC and MNHC have high measurement accuracy.The CFHC is more suitable for short-distance measurement(500 m),while the MNHC can be used for longdistance measurement(>500 m).展开更多
A rapid and continuous method for production of LiFePO4/C nanoparticles in super heated water is described, wherein soluble starch was used as carbon precursor. The effects of pH, flow rate, temperature, and pressure ...A rapid and continuous method for production of LiFePO4/C nanoparticles in super heated water is described, wherein soluble starch was used as carbon precursor. The effects of pH, flow rate, temperature, and pressure on the formation of LiFePO4/C particles were investigated. Results showed that the pH value was the key factot on the formation of phase pure LiFePO4, which only formed at pH = 7; the LiFePO4/C-occurred as particles with about 70-200 nm size and LiFePO4 was covered by a thin carbon layer; higher flow rate, higher pressure, and lower temperature led to smaller particles of LiFePO4/C.展开更多
目的:研究加温输液对剖宫产患者在手术期间体温的影响。方法:300例择期剖宫产患者,随机分为加温输液组(A组)和室温输液组(B组),每组各150例。手术期间A组使用加温输液器输入平衡盐溶液,B组则进行普通输液。比较两组手术情况,不同输液时...目的:研究加温输液对剖宫产患者在手术期间体温的影响。方法:300例择期剖宫产患者,随机分为加温输液组(A组)和室温输液组(B组),每组各150例。手术期间A组使用加温输液器输入平衡盐溶液,B组则进行普通输液。比较两组手术情况,不同输液时间肛温的变化及术中发生寒战情况。结果:两组手术时间及输液时间差异均无统计学意义(P>0.05);B组开始输液后90、120 m in肛温较基础值和A组明显降低(P<0.05),A组寒战发生率(13%),明显低于B组(43%),差异有统计学意义(P<0.05)。结论:加温输液能有效防止剖宫产手术患者围手术期体温降低,并减少寒战的发生。展开更多
Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival out-comes. Positive peritoneal cytology similarly worsens...Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival out-comes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limited. Recent ad-vances in multimodality treatment regimens have led to innovative ways to care for and treat patients with this disease burden. One of these advances has been to use neoadjuvant therapy to try and convert patients with positivecytologyorlow-volume PC to negative cytolo-gy with no evidence of active peritoneal disease.These strategies include the use of neoadjuvant systemic chemotherapy alone,using neoadjuvant laparoscopic heated intraper itoneal chemotherapy(NLHIPEC)after systemic chemotherapy,or using neoadjuvant intra-peritoneal and systemic chemother apy(NIPS)in a bi-dir ectional manner. For patients with higher volume PC,cytoreductive surgery (CRS) and hyperthermic intrape-ritoneal chemotherapy(HIPEC)have been mainstays of treatment. When used together, CRS and HIPEC can improve overall outcomes in properly selected patients,but overall survival outcomes remain unacceptably low.The extent of peritoneal disease, commonly measured by the peritoneal carcinomatosis index (PCI), and the com-pleteness of cytor eduction,has been shown to greatly impact outcomes in patients undergoing CRS and HIPEC.The uses of NLHIPEC and NLHIPEC plus NIPS have both been shown to decrease the PCI and thus increase the opportunity for complete cytoreduction. Newer therapies like pressurized intraperitoneal aerosol chemother apy and immunotherapy, such as catumaxomab, along with improved systemic chemotherapeutic regimens, are being explored with great interest.There is exciting progress being made in the management of PC from gastric can-cer and its’ treatment is no longer futile.展开更多
This review article reports the recent progress in the development of a new group of molecule-based flow diagnostic techniques, which include molecular tag- ging velocimetry （MTV） and molecular tagging thermometry ...This review article reports the recent progress in the development of a new group of molecule-based flow diagnostic techniques, which include molecular tag- ging velocimetry （MTV） and molecular tagging thermometry （MTT）, for both qualitative flow visualization of thermally induced flow structures and quantitative whole-field mea- surements of flow velocity and temperature distributions. The MTV and MTT techniques can also be easily combined to result in a so-called molecular tagging velocimetry and ther- mometry （MTV＆T） technique, which is capble of achieving simultaneous measurements of flow velocity and temperature distribution in fluid flows. Instead of using tiny particles, the molecular tagging techniques （MTV, MTT, and MTV＆T） use phosphorescent molecules, which can be turned into long-lasting glowing marks upon excitation by photons of appropriate wavelength, as the tracers for the flow veloc- ity and temperature measurements. The unique attraction and implementation of the molecular tagging techniques are demonstrated by three application examples, which include： （1） to quantify the unsteady heat transfer process from a heated cylinder to the surrounding fluid flow in order to exam- ine the thermal effects on the wake instabilities behind the heated cylinder operating in mixed and forced heat convec- tion regimes, （2） to reveal the time evolution of unsteady heat transfer and phase changing process inside micro-sized, icing water droplets in order to elucidate the underlying physics pertinent to aircraft icing phenomena, and （3） to achievesimultaneous droplet size, velocity and temperature measure- ments of ＂in-flight＂ droplets to characterize the dynamic and thermodynamic behaviors of flying droplets in spray flows.展开更多
Pseudomyxoma peritonei (PMP) is an uncommon "bor-derline malignancy" generally arising from a perforated appendiceal epithelial tumour. Optimal treatment involves a combination of cytoreductive surgery (CRS)...Pseudomyxoma peritonei (PMP) is an uncommon "bor-derline malignancy" generally arising from a perforated appendiceal epithelial tumour. Optimal treatment involves a combination of cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC). Controversy persists regarding the pathological classification and its prognostic value. Computed tomography scanning is the optimal preoperative staging technique. Tumour marker elevations correlate with worse prognosis and increased recurrence rates. Following CRS with HIPEC, 5-year survival ranges from 62.5% to 100% for low grade, and 0%-65% for high grade disease. Treat-ment related morbidity and mortality ranges from 12 to 67.6%, and 0 to 9%, respectively. Surgery and HIPEC are the optimal treatment for PMP which is at best a "borderline" peritoneal malignancy.展开更多
Fundamental aspects and state-of-the-art results of thermal scanning probe lithography(t-SPL)are reviewed here.t-SPL is an emerging direct-write nanolithography method with many unique properties which enable original...Fundamental aspects and state-of-the-art results of thermal scanning probe lithography(t-SPL)are reviewed here.t-SPL is an emerging direct-write nanolithography method with many unique properties which enable original or improved nano-patterning in application fields ranging from quantum technologies to material science.In particular,ultrafast and highly localized thermal processing of surfaces can be achieved through the sharp heated tip in t-SPL to generate high-resolution patterns.We investigate t-SPL as a means of generating three types of material interaction:removal,conversion,and addition.Each of these categories is illustrated with process parameters and application examples,as well as their respective opportunities and challenges.Our intention is to provide a knowledge base of t-SPL capabilities and current limitations and to guide nanoengineers to the best-fitting approach of t-SPL for their challenges in nanofabrication or material science.Many potential applications of nanoscale modifications with thermal probes still wait to be explored,in particular when one can utilize the inherently ultrahigh heating and cooling rates.展开更多
Convection driven by a spatially non-uniform internal heat source between two horizontal isothermal walls is studied by theoretical analysis and numerical simulation,in order to explore the bounds of the temperature a...Convection driven by a spatially non-uniform internal heat source between two horizontal isothermal walls is studied by theoretical analysis and numerical simulation,in order to explore the bounds of the temperature and the vertical heat flux.Specifically,the rigorous lower bound of the weighted average temperature<QT>is derived analytically,by decomposing the temperature field into a background profile and a fluctuation part.This bound obtained for the first time to consider non-uniform heat sources is found to be compatible with the existing bound obtained in uniform internal heat convection.Of physical importance,an analytical relationship is derived as an inequality connecting<QT>and the average vertical heat flux<wT>,by employing the average heat flux on the bottom wall(qb)as an intermediary variable.It clarifies the intrinsic relation between the lower bound of<QT>and the upper bound of<wT>,namely,these two bounds are essentially equivalent providing an easy way to obtain one from another.Furthermore,the analytical bounds are extensively demonstrated through a comprehensive series of direct numerical simulations.展开更多
At the beginning of the initial cholera outbreak in China,Wang Qingren(王清任),after years of clinical trials,became an early representative who discovered the infectious characteristics and observed the course of cho...At the beginning of the initial cholera outbreak in China,Wang Qingren(王清任),after years of clinical trials,became an early representative who discovered the infectious characteristics and observed the course of cholera in the field of traditional Chinesse medicine(TCM).Kou Langao(寇兰皋)and Xu Zimo(徐子默),both medical practitioners,constructed a diagnosis and treatment system for cholera with cold patterns under the theory of typhoid.They represented“School of Cholera with Cold Patterns”(SCCP).In the 1860s,with the influence of Wang Shixiong’s(王士雄)studies on the nature of cholera under the theory of epidemic febrile disease,the“School of Cholera with Heated Patterns”(SCHP)prevailed thereafter.The two schools complemented each other in theories and contributed to the integrity of TCM in cholera diagnosis and treatment.By reviewing previous literature,books,clinical cases,and historical materials in medical field,this article aims 1)to summarise the influence of TCM on the cognitive development towards cholera in the late Qing dynasty;2)to explore the origin of the controversy between SCCP and SCHP from historical evidence;3)to summarize the historical lessons from the debate over cholera in TCM based on the principle of treatment based on pattern identification,and offer suggestions for the current prevention and treatment of new diseases using TCM.展开更多
2023 will be the inaugural year of a new artificial intelligence(AI) development round. The rapid advancement and proliferation of AI technologies and applications send shock waves worldwide. However, the risks hidden...2023 will be the inaugural year of a new artificial intelligence(AI) development round. The rapid advancement and proliferation of AI technologies and applications send shock waves worldwide. However, the risks hidden behind AI's immense energy have sparked heated debate and controversy. Powered by AI technologies and applications, the intelligent era seems to have begun.展开更多
The application of Golay pulse coding technique in spontaneous Brillouin-based distributed temperature sensor based on self-heterodyne detection of Rayleigh and Brillouin scattering is theoretically and experimentally...The application of Golay pulse coding technique in spontaneous Brillouin-based distributed temperature sensor based on self-heterodyne detection of Rayleigh and Brillouin scattering is theoretically and experimentally analyzed. The enhancement of system signal to noise ratio(SNR) and reduction of temperature measurement error provided by coding are characterized. By using 16-bit Golay coding, SNR can be improved by about 2.77 d B, and temperature measurement error of the 100 m heated fiber is reduced from 1.4 °C to 0.5 °C with a spatial resolution of 13 m. The results are believed to be beneficial for the performance improvement of self-heterodyne detection Brillouin optical time domain reflectometer.展开更多
China is rich of oil shale as one of alternative fossil energy resources.The exploitation and utilization of oil shale are strategically important in alleviating the shortage of oil and gas resources in China.However,...China is rich of oil shale as one of alternative fossil energy resources.The exploitation and utilization of oil shale are strategically important in alleviating the shortage of oil and gas resources in China.However,low utilization rate of raw material,low oil yield,and high content of heavy components in the oil are the main problems in current Fushun type oil shale refinery technology.An indirectly heated moving bed is developed to de-bottleneck Fushun type technology.The oil shale refinery process with the indirectly heated moving bed is modeled and simulated in this work.Based on the simulation,a techno-economic analysis is performed and compared with the conventional Fushun oil shale refinery process.Results show that:for a shale refinery of 3.0 Mt/y scale,375 t/h oil shale retorting requires 149.6 MW of heat,in which 60%of the heat is produced by combustion of the oil shale pyrolysis gas,while remaining 40%from the coal gasified gas.In consideration of investment and operation,the cost of product shale oil of the new process is 2636 CNY/t,which is 12%lower than that of the conventional Fushun refinery process.This benefit comes from higher utilization of raw material and oil yield of the new process.The competitive crude oil price of the indirectly heated moving bed refinery process is about 51$/bbl,while that of the Fushun refinery process is 58$/bbl.During 2017 year,the crude oil price fluctuates at around 50$/bbl,thus the new indirectly heated moving bed refinery process shows better economic competitiveness.展开更多
基金partial financial support under grant FA9550-14-1-0279.
文摘Presently,liquid crystal displays(LCDs)and organic light-emitting diode(OLED)displays are two dominant flat panel display technologies.Recently,inorganic mini-LEDs(mLEDs)and micro-LEDs(μLEDs)have emerged by significantly enhancing the dynamic range of LCDs or as sunlight readable emissive displays.“mLED,OLED,orμLED:who wins?”is a heated debatable question.In this review,we conduct a comprehensive analysis on the material properties,device structures,and performance of mLED/μLED/OLED emissive displays and mLED backlit LCDs.We evaluate the power consumption and ambient contrast ratio of each display in depth and systematically compare the motion picture response time,dynamic range,and adaptability to flexible/transparent displays.The pros and cons of mLED,OLED,andμLED displays are analysed,and their future perspectives are discussed.
基金supported by National Basic Research Program of China(No.2013CB035701)the Fundamental Research Funds for the Central Universitiesthe National Program for Support of Top-notch Young Professionals
文摘Thermally sprayed coatings are essentially layered materials and contain large numbers of lamellar pores. It is thus quite necessary to clarify the formation mechanism of lamellar pores which significantly influence coating performances. In the present study, to elaborate the formation mechanism of lamellar pores, the yttria-stabilized zirconia(ZrO_2–7 wt% Y_2O_3, 7YSZ) splats, which have high fracture toughness and tetragonal phase stability, were employed. Interestingly, anomalous epitaxial growth occurred for all deposition temperatures in spite of the extremely high cooling rate,which clearly indicated chemical bonding and complete contact at splat/substrate interface before splat cooling. However, transverse spallation substantially occurred for all deposition temperatures in spite of the high fracture toughness of 7YSZ, which revealed that the lamellar pores were from transverse cracking/spallation due to the large stress during splat cooling. Additionally, fracture mechanics analysis was carried out, and it was found that the stress arose from the constraint effect of the shrinkage of the splat by locally heated substrate with the value about 1.97 GPa. This clearly demonstrated that the stress was indeed large enough to drive transverse cracking/spallation forming lamellar pores during splat cooling. All of these contribute to understanding the essential features of lamellar bonding and further tailoring the coating structures and performance.
基金support of this work by the National Natural Science Foundation of China (No.50776006)
文摘An experimental system of flat plate pulsating heat pipe was established and experimental research was carried out in this system to know the mechanism of heat transfer, start-up and operating characteristics. The factors, such as filling rate, heating power, heating method etc, which have great influence on the thermal performance of the plate pulsating heat pipe were discussed. The results indicate that heating power and filling rate are the important factors for the start-up of the plate pulsating heat pipe. The different start-up power is needed with different filling rate, and the start-up of the heat pipe in case of bottom heated is much easier than that of top heated. Increasing the heating power and enlarging the heating area can make the start-up easier. Heating power can also affect the start-up time of heat pipe under the condition of bottom heated, while it does not have some influence to the heat pipe of top heated. The thermal resistance of plate pulsating heat pipe is related with the heating power, and the higher the heating power is, the smaller the thermal resistance is. But the best filling rate which the heat pipe needs is different with different heating methods, and the performance of the heat pipe in the case of bottom heated is better than the others.
基金The financial supports provided by the National Natural Science Foundation of China(Grant Nos.41230636,41372265,41427801)National Basic Research Program of China(973 Project)(Grant No.2011CB710605)
文摘Moisture content is a fundamental physical index that quantifies soil property and is closely associatedwith the hydrological, ecological and engineering behaviors of soil. To measure in-situ soil moisturecontents, a distributed measurement system for in-situ soil moisture content （SM-DTS） is introduced.The system is based on carbon-fiber heated cable （CFHC） technology that has been developed to enhancethe measuring accuracy of in-situ soil moisture content. Using CFHC technique, a temperature characteristicvalue （Tt） can be defined from temperatureetime curves. A relationship among Tt, soil thermalimpedance coefficient and soil moisture content is then established in laboratory. The feasibility of theSM-DTS technology to provide distributed measurements of in-situ soil moisture content is verifiedthrough field tests. The research reported herein indicates that the proposed SM-DTS is capable ofmeasuring in-situ soil moisture content over long distances and large areas.
基金The financial supports provided by the National Natural Science Foundation of China(Grant Nos.41230636,41372265,41427801)National Basic Research Program of China(973 Project)(Grant No.2011CB710605)
文摘Distributed temperature sensing(DTS)using heated cables has been recently developed for distributed monitoring of in-situ soil moisture content.In this method,the thermal and electrical properties of heated cables have a significant influence on the measurement accuracy of soil moisture content.In this paper,the performances of two heated cables,i.e.the carbon-fiber heated cable(CFHC)and the metalnet heated cable(MNHC),are studied in the laboratory.Their structures,uniformity in the axial direction,measurement accuracy and suitability are evaluated.The test results indicate that the MNHC has a better uniformity in the axial direction than CFHC.Both CFHC and MNHC have high measurement accuracy.The CFHC is more suitable for short-distance measurement(500 m),while the MNHC can be used for longdistance measurement(>500 m).
基金Supported by Shanghai Special Foundation on Nanomaterials (0243nm305)
文摘A rapid and continuous method for production of LiFePO4/C nanoparticles in super heated water is described, wherein soluble starch was used as carbon precursor. The effects of pH, flow rate, temperature, and pressure on the formation of LiFePO4/C particles were investigated. Results showed that the pH value was the key factot on the formation of phase pure LiFePO4, which only formed at pH = 7; the LiFePO4/C-occurred as particles with about 70-200 nm size and LiFePO4 was covered by a thin carbon layer; higher flow rate, higher pressure, and lower temperature led to smaller particles of LiFePO4/C.
文摘目的:研究加温输液对剖宫产患者在手术期间体温的影响。方法:300例择期剖宫产患者,随机分为加温输液组(A组)和室温输液组(B组),每组各150例。手术期间A组使用加温输液器输入平衡盐溶液,B组则进行普通输液。比较两组手术情况,不同输液时间肛温的变化及术中发生寒战情况。结果:两组手术时间及输液时间差异均无统计学意义(P>0.05);B组开始输液后90、120 m in肛温较基础值和A组明显降低(P<0.05),A组寒战发生率(13%),明显低于B组(43%),差异有统计学意义(P<0.05)。结论:加温输液能有效防止剖宫产手术患者围手术期体温降低,并减少寒战的发生。
文摘Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival out-comes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limited. Recent ad-vances in multimodality treatment regimens have led to innovative ways to care for and treat patients with this disease burden. One of these advances has been to use neoadjuvant therapy to try and convert patients with positivecytologyorlow-volume PC to negative cytolo-gy with no evidence of active peritoneal disease.These strategies include the use of neoadjuvant systemic chemotherapy alone,using neoadjuvant laparoscopic heated intraper itoneal chemotherapy(NLHIPEC)after systemic chemotherapy,or using neoadjuvant intra-peritoneal and systemic chemother apy(NIPS)in a bi-dir ectional manner. For patients with higher volume PC,cytoreductive surgery (CRS) and hyperthermic intrape-ritoneal chemotherapy(HIPEC)have been mainstays of treatment. When used together, CRS and HIPEC can improve overall outcomes in properly selected patients,but overall survival outcomes remain unacceptably low.The extent of peritoneal disease, commonly measured by the peritoneal carcinomatosis index (PCI), and the com-pleteness of cytor eduction,has been shown to greatly impact outcomes in patients undergoing CRS and HIPEC.The uses of NLHIPEC and NLHIPEC plus NIPS have both been shown to decrease the PCI and thus increase the opportunity for complete cytoreduction. Newer therapies like pressurized intraperitoneal aerosol chemother apy and immunotherapy, such as catumaxomab, along with improved systemic chemotherapeutic regimens, are being explored with great interest.There is exciting progress being made in the management of PC from gastric can-cer and its’ treatment is no longer futile.
基金supported by the National Aeronauticaland Space Administration(NASA)(Grant NNX12AC21A)The support of the National Science Foundation(NSF)under award numbers of CBET-1064196,IIA-1064235 and CBET-1435590
文摘This review article reports the recent progress in the development of a new group of molecule-based flow diagnostic techniques, which include molecular tag- ging velocimetry （MTV） and molecular tagging thermometry （MTT）, for both qualitative flow visualization of thermally induced flow structures and quantitative whole-field mea- surements of flow velocity and temperature distributions. The MTV and MTT techniques can also be easily combined to result in a so-called molecular tagging velocimetry and ther- mometry （MTV＆T） technique, which is capble of achieving simultaneous measurements of flow velocity and temperature distribution in fluid flows. Instead of using tiny particles, the molecular tagging techniques （MTV, MTT, and MTV＆T） use phosphorescent molecules, which can be turned into long-lasting glowing marks upon excitation by photons of appropriate wavelength, as the tracers for the flow veloc- ity and temperature measurements. The unique attraction and implementation of the molecular tagging techniques are demonstrated by three application examples, which include： （1） to quantify the unsteady heat transfer process from a heated cylinder to the surrounding fluid flow in order to exam- ine the thermal effects on the wake instabilities behind the heated cylinder operating in mixed and forced heat convec- tion regimes, （2） to reveal the time evolution of unsteady heat transfer and phase changing process inside micro-sized, icing water droplets in order to elucidate the underlying physics pertinent to aircraft icing phenomena, and （3） to achievesimultaneous droplet size, velocity and temperature measure- ments of ＂in-flight＂ droplets to characterize the dynamic and thermodynamic behaviors of flying droplets in spray flows.
文摘Pseudomyxoma peritonei (PMP) is an uncommon "bor-derline malignancy" generally arising from a perforated appendiceal epithelial tumour. Optimal treatment involves a combination of cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC). Controversy persists regarding the pathological classification and its prognostic value. Computed tomography scanning is the optimal preoperative staging technique. Tumour marker elevations correlate with worse prognosis and increased recurrence rates. Following CRS with HIPEC, 5-year survival ranges from 62.5% to 100% for low grade, and 0%-65% for high grade disease. Treat-ment related morbidity and mortality ranges from 12 to 67.6%, and 0 to 9%, respectively. Surgery and HIPEC are the optimal treatment for PMP which is at best a "borderline" peritoneal malignancy.
基金This review paper is part of a project that has received funding from the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation program(Project“MEMS 4.0”,ERC-2016-ADG,grant agreement No.742685).
文摘Fundamental aspects and state-of-the-art results of thermal scanning probe lithography(t-SPL)are reviewed here.t-SPL is an emerging direct-write nanolithography method with many unique properties which enable original or improved nano-patterning in application fields ranging from quantum technologies to material science.In particular,ultrafast and highly localized thermal processing of surfaces can be achieved through the sharp heated tip in t-SPL to generate high-resolution patterns.We investigate t-SPL as a means of generating three types of material interaction:removal,conversion,and addition.Each of these categories is illustrated with process parameters and application examples,as well as their respective opportunities and challenges.Our intention is to provide a knowledge base of t-SPL capabilities and current limitations and to guide nanoengineers to the best-fitting approach of t-SPL for their challenges in nanofabrication or material science.Many potential applications of nanoscale modifications with thermal probes still wait to be explored,in particular when one can utilize the inherently ultrahigh heating and cooling rates.
基金supported by the National Natural Science Foundation of China(Grant Nos.92252202,92152301,12293000,12293002,12302320,and 12388101)the Fundamental Research Funds for the Central Universities.
文摘Convection driven by a spatially non-uniform internal heat source between two horizontal isothermal walls is studied by theoretical analysis and numerical simulation,in order to explore the bounds of the temperature and the vertical heat flux.Specifically,the rigorous lower bound of the weighted average temperature<QT>is derived analytically,by decomposing the temperature field into a background profile and a fluctuation part.This bound obtained for the first time to consider non-uniform heat sources is found to be compatible with the existing bound obtained in uniform internal heat convection.Of physical importance,an analytical relationship is derived as an inequality connecting<QT>and the average vertical heat flux<wT>,by employing the average heat flux on the bottom wall(qb)as an intermediary variable.It clarifies the intrinsic relation between the lower bound of<QT>and the upper bound of<wT>,namely,these two bounds are essentially equivalent providing an easy way to obtain one from another.Furthermore,the analytical bounds are extensively demonstrated through a comprehensive series of direct numerical simulations.
基金This study is financed by the grants from the Fundamental Research Funds for the Central Universities(No.23JNQMX48 and No.23JNSYS04)Major Project of the Key Research Bases of Humanities and Social Sciences of Ministry of Education(No.22JJD770054).
文摘At the beginning of the initial cholera outbreak in China,Wang Qingren(王清任),after years of clinical trials,became an early representative who discovered the infectious characteristics and observed the course of cholera in the field of traditional Chinesse medicine(TCM).Kou Langao(寇兰皋)and Xu Zimo(徐子默),both medical practitioners,constructed a diagnosis and treatment system for cholera with cold patterns under the theory of typhoid.They represented“School of Cholera with Cold Patterns”(SCCP).In the 1860s,with the influence of Wang Shixiong’s(王士雄)studies on the nature of cholera under the theory of epidemic febrile disease,the“School of Cholera with Heated Patterns”(SCHP)prevailed thereafter.The two schools complemented each other in theories and contributed to the integrity of TCM in cholera diagnosis and treatment.By reviewing previous literature,books,clinical cases,and historical materials in medical field,this article aims 1)to summarise the influence of TCM on the cognitive development towards cholera in the late Qing dynasty;2)to explore the origin of the controversy between SCCP and SCHP from historical evidence;3)to summarize the historical lessons from the debate over cholera in TCM based on the principle of treatment based on pattern identification,and offer suggestions for the current prevention and treatment of new diseases using TCM.
文摘2023 will be the inaugural year of a new artificial intelligence(AI) development round. The rapid advancement and proliferation of AI technologies and applications send shock waves worldwide. However, the risks hidden behind AI's immense energy have sparked heated debate and controversy. Powered by AI technologies and applications, the intelligent era seems to have begun.
基金supported by the National Natural Science Foundation of China(No.61377088)the Natural Science Foundation of Hebei Province of China(Nos.E2015502053 and F2014502098)
文摘The application of Golay pulse coding technique in spontaneous Brillouin-based distributed temperature sensor based on self-heterodyne detection of Rayleigh and Brillouin scattering is theoretically and experimentally analyzed. The enhancement of system signal to noise ratio(SNR) and reduction of temperature measurement error provided by coding are characterized. By using 16-bit Golay coding, SNR can be improved by about 2.77 d B, and temperature measurement error of the 100 m heated fiber is reduced from 1.4 °C to 0.5 °C with a spatial resolution of 13 m. The results are believed to be beneficial for the performance improvement of self-heterodyne detection Brillouin optical time domain reflectometer.
基金the National Basic Research Program(2014CB744306)the China NSF projects(21676101 and 21736004).
文摘China is rich of oil shale as one of alternative fossil energy resources.The exploitation and utilization of oil shale are strategically important in alleviating the shortage of oil and gas resources in China.However,low utilization rate of raw material,low oil yield,and high content of heavy components in the oil are the main problems in current Fushun type oil shale refinery technology.An indirectly heated moving bed is developed to de-bottleneck Fushun type technology.The oil shale refinery process with the indirectly heated moving bed is modeled and simulated in this work.Based on the simulation,a techno-economic analysis is performed and compared with the conventional Fushun oil shale refinery process.Results show that:for a shale refinery of 3.0 Mt/y scale,375 t/h oil shale retorting requires 149.6 MW of heat,in which 60%of the heat is produced by combustion of the oil shale pyrolysis gas,while remaining 40%from the coal gasified gas.In consideration of investment and operation,the cost of product shale oil of the new process is 2636 CNY/t,which is 12%lower than that of the conventional Fushun refinery process.This benefit comes from higher utilization of raw material and oil yield of the new process.The competitive crude oil price of the indirectly heated moving bed refinery process is about 51$/bbl,while that of the Fushun refinery process is 58$/bbl.During 2017 year,the crude oil price fluctuates at around 50$/bbl,thus the new indirectly heated moving bed refinery process shows better economic competitiveness.
