幽门螺杆菌(Helicobacter pylori,Hp)是引起慢性胃炎、消化性溃疡及胃癌的重要病因,几乎所有胃部 Hp 感染者均可引起不同程度胃部炎症改变,少数发展为慢性萎缩性胃炎(chronic atrophic gastritis,CAG),甚至胃癌.关于 Hp 感染导致 CAG ...幽门螺杆菌(Helicobacter pylori,Hp)是引起慢性胃炎、消化性溃疡及胃癌的重要病因,几乎所有胃部 Hp 感染者均可引起不同程度胃部炎症改变,少数发展为慢性萎缩性胃炎(chronic atrophic gastritis,CAG),甚至胃癌.关于 Hp 感染导致 CAG 的确切发病机制,目前仍不十分清楚.现就 CAG与 Hp 感染关系的研究现状作一综述.展开更多
Cell protection from stresses by heat shock protein (HSP) was previously attributed to its ability to prevent aggregation and to accelerate refolding of damaged proteins. It plays an important role in cell survival af...Cell protection from stresses by heat shock protein (HSP) was previously attributed to its ability to prevent aggregation and to accelerate refolding of damaged proteins. It plays an important role in cell survival after extremely harsh protein damaging treatment leading to necrotic cell death. On the other hand, protein repair function of HSP cannot explain how it protects cell from stresses which do not cause direct protein damage. These stresses kill cell through activation of apoptotic program. Recently it has been found that HSP can meditate suppression of a stress-activated protein kinase, JNK, an early component of stress-induced apoptotic signaling pathway.These observations can provide a basis for HSP’s function of anti-apoptosis.展开更多
文摘幽门螺杆菌(Helicobacter pylori,Hp)是引起慢性胃炎、消化性溃疡及胃癌的重要病因,几乎所有胃部 Hp 感染者均可引起不同程度胃部炎症改变,少数发展为慢性萎缩性胃炎(chronic atrophic gastritis,CAG),甚至胃癌.关于 Hp 感染导致 CAG 的确切发病机制,目前仍不十分清楚.现就 CAG与 Hp 感染关系的研究现状作一综述.
文摘Cell protection from stresses by heat shock protein (HSP) was previously attributed to its ability to prevent aggregation and to accelerate refolding of damaged proteins. It plays an important role in cell survival after extremely harsh protein damaging treatment leading to necrotic cell death. On the other hand, protein repair function of HSP cannot explain how it protects cell from stresses which do not cause direct protein damage. These stresses kill cell through activation of apoptotic program. Recently it has been found that HSP can meditate suppression of a stress-activated protein kinase, JNK, an early component of stress-induced apoptotic signaling pathway.These observations can provide a basis for HSP’s function of anti-apoptosis.
