目的探讨立体脑电图(SEEG)电极介导的射频热凝(RFTC)治疗局灶性皮质发育不良(FCD)Ⅱ型药物难治性癫痫患者的疗效,并分析其病灶毁损程度与疗效的相关性.方法回顾性分析2017年10月至2021年11月广东三九脑科医院神经外科应用SEEG电极介导R...目的探讨立体脑电图(SEEG)电极介导的射频热凝(RFTC)治疗局灶性皮质发育不良(FCD)Ⅱ型药物难治性癫痫患者的疗效,并分析其病灶毁损程度与疗效的相关性.方法回顾性分析2017年10月至2021年11月广东三九脑科医院神经外科应用SEEG电极介导RFTC治疗的31例FCDⅡ型药物难治性癫痫患者的临床资料.31例患者的FCD病灶位于额叶13例,中央区17例,顶叶1例.观察毁损术后的并发症及改良Engel分级;癫痫控制疗效以癫痫发作减少程度评估.根据术前头颅MRI液体衰减反转恢复序列和术后头颅MRI 3D T1加权成像,运用MATLAB软件测量各病灶、毁损灶三维模块的体积.将术前FCD病灶与RFTC毁损灶在空间上的重叠部分的体积定义为病灶的有效毁损体积,其占术前FCD病灶的比率即为病灶毁损程度(%).根据病灶毁损程度是否≥40%将患者分为毁损充分组与毁损欠充分组,比较两组患者Engel分级Ⅰ级者的比例.采用Spearman法分析病灶毁损程度与癫痫控制疗效的相关性.结果31例患者的RFTC手术均顺利完成,毁损靶点数[M(Q_(1),Q_(3))]为20(14,26)个.8例病灶位于中央区的患者在RFTC治疗后出现暂时性手术对侧肢体肌力轻度下降.31例患者的随访时间[M(Q_(1),Q_(3))]为38(7,50)个月.至末次随访,Engle分级Ⅰ级17例(54.8%),Ⅱ级3例(9.7%),Ⅲ级6例(19.4%),Ⅳ级5例(16.1%);癫痫发作减少程度[M(Q_(1),Q_(3))]为100%(58%,100%).8例(25.8%)患者因疗效欠佳进一步行病灶及致痫区切除性手术,术后均未再出现癫痫发作.31例患者FCD病灶的体积[M(Q_(1),Q_(3))]为1735(1176,2857)mm^(3).31例患者的毁损灶体积[M(Q_(1),Q_(3))]为1436(1255,2607)mm^(3),有效毁损体积为591(410,932)mm^(3),病灶的毁损程度为37%(30%,57%).Spearman相关分析结果显示,病灶毁损程度与癫痫发作减少程度呈正相关(Spearman相关系数为0.61,P<0.001).与毁损欠充分组(18例)比较,毁损充分组(13例)Engle分级Ⅰ级者占比高(分别为12/13�展开更多
目的探讨不同级别前列腺癌中己糖激酶Ⅱ(hexokinaseⅡ,HKⅡ)和前列腺特异性抗原(prostate specific antigen,PSA)的表达。方法收集35例正常前列腺组织及189例前列腺癌手术标本,在HE染色下根据危险程度将前列腺癌分为低级别和高级别组,...目的探讨不同级别前列腺癌中己糖激酶Ⅱ(hexokinaseⅡ,HKⅡ)和前列腺特异性抗原(prostate specific antigen,PSA)的表达。方法收集35例正常前列腺组织及189例前列腺癌手术标本,在HE染色下根据危险程度将前列腺癌分为低级别和高级别组,应用免疫组化EnVision两步法染色检测HKⅡ和PSA在不同前列腺组织中的表达,并分析HKⅡ和PSA表达与前列腺癌临床病理学特征的关系及两者的相关性。结果HKⅡ在正常前列腺组织(14.3%)、低级别前列腺癌(52.7%)及高级别前列腺癌(74.0%)的高表达率逐渐升高(P<0.05);在189例前列腺癌中,HKⅡ表达与Gleason评分、组织学分级及分期有关(P<0.05)。与正常前列腺组织(37.1%)相比,PSA在前列腺癌中(96.3%)的高表达率明显升高(P<0.05)。前列腺癌中HKⅡ与PSA表达呈正相关(P=0.019)。结论HKⅡ和PSA在前列腺癌中高表达,随着前列腺癌的进展,HKⅡ的高表达率呈逐渐升高的趋势,且HKⅡ和PSA表达呈显著相关性,提示HKⅡ联合PSA检测有望成为前列腺癌预后评估的潜在生物学标志物,为前列腺癌患者的治疗提供新思路。展开更多
The physical trend of group-I/tellurides is unexpected and contrary to the conventional wisdom. The present firstprinciples calculations give fundamental insights into the extent to which group-Ⅱ telluride compounds ...The physical trend of group-I/tellurides is unexpected and contrary to the conventional wisdom. The present firstprinciples calculations give fundamental insights into the extent to which group-Ⅱ telluride compounds present special properties upon mixing the d valence character. Our results provide explanations for the unexpected experimental observations based on the abnormal binding ordering of metal d electrons and their strong perturbation to the band edge states. The insights into the binary tellurides are useful for the study and control of the structural and chemical perturbation in their ternary alloys and heterostructures.展开更多
Recently,a class of Type Ⅱ factors has been constructed,arising from holomorphic coverings of bounded planar domains.Those operators in Type Ⅱ factors act on the Bergman space.In this paper,we develop new techniques...Recently,a class of Type Ⅱ factors has been constructed,arising from holomorphic coverings of bounded planar domains.Those operators in Type Ⅱ factors act on the Bergman space.In this paper,we develop new techniques to generalize those results to the case of the weighted Bergman spaces.In addition,a class of group-like von Neumann algebras are constructed,which are shown to be-isomorphic to the group von Neumann algebras.展开更多
The crystal structure of the title complex, [Cu(C23H26N2)Cl2]2·2CH2Cl2, has been determined by single-crystal, X-ray diffraction techniques. The compound crystallizes as dark-green prisms in space group P21/c of ...The crystal structure of the title complex, [Cu(C23H26N2)Cl2]2·2CH2Cl2, has been determined by single-crystal, X-ray diffraction techniques. The compound crystallizes as dark-green prisms in space group P21/c of the monoclinic system, with Z=4 and unit cell dimensions a=1.710 9(7) nm, b=2.395 2(11) nm, c=1.348 9(6) nm and β=110.651(8)°. The complex consists of two similar but crystallographically independent dimers, of which Cu(Ⅱ) centers display five-coordinated trigonal-bipyramidal geometry with Cu-Cu separations in two centrosymmetric dimers are 0.345 1 and 0.347 8 nm, respectively, and in each dimer the two copper centers share a common edge formed by two bridging chloride ions, each being equatorial. Solvent molecules of CH2Cl2 are packed together in the crystal lattice. CCDC: 253299.展开更多
文摘目的探讨立体脑电图(SEEG)电极介导的射频热凝(RFTC)治疗局灶性皮质发育不良(FCD)Ⅱ型药物难治性癫痫患者的疗效,并分析其病灶毁损程度与疗效的相关性.方法回顾性分析2017年10月至2021年11月广东三九脑科医院神经外科应用SEEG电极介导RFTC治疗的31例FCDⅡ型药物难治性癫痫患者的临床资料.31例患者的FCD病灶位于额叶13例,中央区17例,顶叶1例.观察毁损术后的并发症及改良Engel分级;癫痫控制疗效以癫痫发作减少程度评估.根据术前头颅MRI液体衰减反转恢复序列和术后头颅MRI 3D T1加权成像,运用MATLAB软件测量各病灶、毁损灶三维模块的体积.将术前FCD病灶与RFTC毁损灶在空间上的重叠部分的体积定义为病灶的有效毁损体积,其占术前FCD病灶的比率即为病灶毁损程度(%).根据病灶毁损程度是否≥40%将患者分为毁损充分组与毁损欠充分组,比较两组患者Engel分级Ⅰ级者的比例.采用Spearman法分析病灶毁损程度与癫痫控制疗效的相关性.结果31例患者的RFTC手术均顺利完成,毁损靶点数[M(Q_(1),Q_(3))]为20(14,26)个.8例病灶位于中央区的患者在RFTC治疗后出现暂时性手术对侧肢体肌力轻度下降.31例患者的随访时间[M(Q_(1),Q_(3))]为38(7,50)个月.至末次随访,Engle分级Ⅰ级17例(54.8%),Ⅱ级3例(9.7%),Ⅲ级6例(19.4%),Ⅳ级5例(16.1%);癫痫发作减少程度[M(Q_(1),Q_(3))]为100%(58%,100%).8例(25.8%)患者因疗效欠佳进一步行病灶及致痫区切除性手术,术后均未再出现癫痫发作.31例患者FCD病灶的体积[M(Q_(1),Q_(3))]为1735(1176,2857)mm^(3).31例患者的毁损灶体积[M(Q_(1),Q_(3))]为1436(1255,2607)mm^(3),有效毁损体积为591(410,932)mm^(3),病灶的毁损程度为37%(30%,57%).Spearman相关分析结果显示,病灶毁损程度与癫痫发作减少程度呈正相关(Spearman相关系数为0.61,P<0.001).与毁损欠充分组(18例)比较,毁损充分组(13例)Engle分级Ⅰ级者占比高(分别为12/13�
文摘目的探讨不同级别前列腺癌中己糖激酶Ⅱ(hexokinaseⅡ,HKⅡ)和前列腺特异性抗原(prostate specific antigen,PSA)的表达。方法收集35例正常前列腺组织及189例前列腺癌手术标本,在HE染色下根据危险程度将前列腺癌分为低级别和高级别组,应用免疫组化EnVision两步法染色检测HKⅡ和PSA在不同前列腺组织中的表达,并分析HKⅡ和PSA表达与前列腺癌临床病理学特征的关系及两者的相关性。结果HKⅡ在正常前列腺组织(14.3%)、低级别前列腺癌(52.7%)及高级别前列腺癌(74.0%)的高表达率逐渐升高(P<0.05);在189例前列腺癌中,HKⅡ表达与Gleason评分、组织学分级及分期有关(P<0.05)。与正常前列腺组织(37.1%)相比,PSA在前列腺癌中(96.3%)的高表达率明显升高(P<0.05)。前列腺癌中HKⅡ与PSA表达呈正相关(P=0.019)。结论HKⅡ和PSA在前列腺癌中高表达,随着前列腺癌的进展,HKⅡ的高表达率呈逐渐升高的趋势,且HKⅡ和PSA表达呈显著相关性,提示HKⅡ联合PSA检测有望成为前列腺癌预后评估的潜在生物学标志物,为前列腺癌患者的治疗提供新思路。
基金supported by the National Natural Science Foundation of China (Grant Nos. 10847111 and 61006091)the Startup Project for Ph. D. of Guangdong University of Technology (Grant No. 083034)the Fundamental Research Funds for the Central Universities of South China University of Technology (Grant No. 2009ZM0022)
文摘The physical trend of group-I/tellurides is unexpected and contrary to the conventional wisdom. The present firstprinciples calculations give fundamental insights into the extent to which group-Ⅱ telluride compounds present special properties upon mixing the d valence character. Our results provide explanations for the unexpected experimental observations based on the abnormal binding ordering of metal d electrons and their strong perturbation to the band edge states. The insights into the binary tellurides are useful for the study and control of the structural and chemical perturbation in their ternary alloys and heterostructures.
基金supported by National Natural Science Foundation of China (Grant No.11001078)Shanghai Municipal Education Commission and Shanghai Education Development Foundation (GrantNo. 11CG30)
文摘Recently,a class of Type Ⅱ factors has been constructed,arising from holomorphic coverings of bounded planar domains.Those operators in Type Ⅱ factors act on the Bergman space.In this paper,we develop new techniques to generalize those results to the case of the weighted Bergman spaces.In addition,a class of group-like von Neumann algebras are constructed,which are shown to be-isomorphic to the group von Neumann algebras.
文摘The crystal structure of the title complex, [Cu(C23H26N2)Cl2]2·2CH2Cl2, has been determined by single-crystal, X-ray diffraction techniques. The compound crystallizes as dark-green prisms in space group P21/c of the monoclinic system, with Z=4 and unit cell dimensions a=1.710 9(7) nm, b=2.395 2(11) nm, c=1.348 9(6) nm and β=110.651(8)°. The complex consists of two similar but crystallographically independent dimers, of which Cu(Ⅱ) centers display five-coordinated trigonal-bipyramidal geometry with Cu-Cu separations in two centrosymmetric dimers are 0.345 1 and 0.347 8 nm, respectively, and in each dimer the two copper centers share a common edge formed by two bridging chloride ions, each being equatorial. Solvent molecules of CH2Cl2 are packed together in the crystal lattice. CCDC: 253299.
