Glycolipids are lipid compounds,which are a type of amphiphilic molecules containing glycosyl ligands.This experiment studied the efficacy of glycolipids on acne skin care from the aspects of antibacterial,anti-inflam...Glycolipids are lipid compounds,which are a type of amphiphilic molecules containing glycosyl ligands.This experiment studied the efficacy of glycolipids on acne skin care from the aspects of antibacterial,anti-inflammatory,anti-allergic,oil-control,soothing and repair.Research results show that glycolipids have excellent antibacterial properties against P.acnes;when the dosage of glycolipids reaches 10μg/mL,the inhibition rate of glycolipids on lipid synthesis in SZ95 cells can reach 20%;glycolipids can induce LPS induction RAW264.7 cells have the inhibitory effect on the release of inflammatory factors IL-6 and NO;when the glycolipids concentration is 15 mg/mL,the inhibition rate of glycolipids on hyaluronidase reaches 45.8%;when the glycolipids concentration is 25μg/mL,the inhibition rate on calcium ion concentration reaches 45.3%;glycolipids have a significant promoting effect on wound healing.Furthermore,human efficacy evaluation shows that glycolipids products have comprehensive care effects on acne skin.This study will help further promote the application of glycolipids in cosmetic products,especially in skin care products for acne skin.展开更多
Gangliosides,sialic acid-containing sphingolipids,are major constituents of neuronal membranes.According to the number of sialic acids and the structure of the oligosaccharide chain,gangliosides can be classified as s...Gangliosides,sialic acid-containing sphingolipids,are major constituents of neuronal membranes.According to the number of sialic acids and the structure of the oligosaccharide chain,gangliosides can be classified as simple or complex and grouped in different ganglio-series.Hundreds of gangliosides have been identified in vertebrate cells,with different expression patterns during development and related to several physiological processes,especially in the nervous system.While GD3 and its O-acetylated form,9acGD3,are highly expressed in early developmental stages,GM1,GD1a,GD1b,and GT1b are the most abundant ganglioside species in the mature nervous system.Mutations in enzymes involved in ganglioside metabolism can lead to the accumulation of specific species,a condition termed gangliosidosis and usually marked by severe neurological impairment.Changes in ganglioside levels have also been described in several neurodegenerative diseases,such as Alzheimer’s and Parkinson’s.In this review,we summarized recent information about the roles of GD3,9acGD3,GM1,GD1a,GD1b,GT1b,and other ganglioside species in nervous system development and regeneration,as well as clinical trials evaluating possible therapeutic applications of these molecules.展开更多
The extraction and solvent fi＇actionation of red alga Symphyocladia latiuscula, and repeated column chromatography led to isolation of 17 compounds： cholesterol （1）, 313,5β-dihydroxy-B-norcholestan-6βcarboxaldeh...The extraction and solvent fi＇actionation of red alga Symphyocladia latiuscula, and repeated column chromatography led to isolation of 17 compounds： cholesterol （1）, 313,5β-dihydroxy-B-norcholestan-6βcarboxaldehyde （2）, 6β-hydroxy-cholest-4-ene- 3-one （3）, 1-O-myristoyl-3-O-（6＇-sulfo-α-D-quinovopyranosyl）glycerol （4）, 1-O-palmitoyl-3-O-（6＇-sulfo-u-19-quinovopyranosyl） glycerol （5）, 1-O-palmitoyl-3-O-[α-D-galactopyranosyl（1→6）β-D-galactopyranosyl] glycerol （6）, 1-O-palmitoyl-3-O-β-D- galactopyranosylglycerol （7）, methyl hexadecanoate （8）, methyl stearate （9）, hexadecanoic acid （10）, γ-n-butyl cis-aconiate （11）, α-n-Butyl cis-aconiate （12）, phenethylamine （13）, 3,5-dibromo-L-tyrosine （14）, 3-methylbutylamine （15）, methyl pyroglutamate （16）, n-butyl pyroglutamate （17）. The structures of these compounds were identified by NMR spectroscopy and mass spectrometry, and compared with those reported in the literature. All the compounds were isolated from Symphyocladia genus for the first time. These compounds were investigated for their inhibitory effects on human recombinant aldose reductase in vitro. Of the compounds, 1-O-palmitoyl-3-O-β-D-galactopyranosylglycerol （7） demonstrated moderate enzyme inhibition.展开更多
文摘Glycolipids are lipid compounds,which are a type of amphiphilic molecules containing glycosyl ligands.This experiment studied the efficacy of glycolipids on acne skin care from the aspects of antibacterial,anti-inflammatory,anti-allergic,oil-control,soothing and repair.Research results show that glycolipids have excellent antibacterial properties against P.acnes;when the dosage of glycolipids reaches 10μg/mL,the inhibition rate of glycolipids on lipid synthesis in SZ95 cells can reach 20%;glycolipids can induce LPS induction RAW264.7 cells have the inhibitory effect on the release of inflammatory factors IL-6 and NO;when the glycolipids concentration is 15 mg/mL,the inhibition rate of glycolipids on hyaluronidase reaches 45.8%;when the glycolipids concentration is 25μg/mL,the inhibition rate on calcium ion concentration reaches 45.3%;glycolipids have a significant promoting effect on wound healing.Furthermore,human efficacy evaluation shows that glycolipids products have comprehensive care effects on acne skin.This study will help further promote the application of glycolipids in cosmetic products,especially in skin care products for acne skin.
基金supported by grants and fellowships from the Departamento de Ciência e Tecnologia(DECIT/MS)do Ministério da Saúde,Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa,Fundação de AmparoàPesquisa do Estado do Rio de Janeiro(FAPERJ)(to RMO).
文摘Gangliosides,sialic acid-containing sphingolipids,are major constituents of neuronal membranes.According to the number of sialic acids and the structure of the oligosaccharide chain,gangliosides can be classified as simple or complex and grouped in different ganglio-series.Hundreds of gangliosides have been identified in vertebrate cells,with different expression patterns during development and related to several physiological processes,especially in the nervous system.While GD3 and its O-acetylated form,9acGD3,are highly expressed in early developmental stages,GM1,GD1a,GD1b,and GT1b are the most abundant ganglioside species in the mature nervous system.Mutations in enzymes involved in ganglioside metabolism can lead to the accumulation of specific species,a condition termed gangliosidosis and usually marked by severe neurological impairment.Changes in ganglioside levels have also been described in several neurodegenerative diseases,such as Alzheimer’s and Parkinson’s.In this review,we summarized recent information about the roles of GD3,9acGD3,GM1,GD1a,GD1b,GT1b,and other ganglioside species in nervous system development and regeneration,as well as clinical trials evaluating possible therapeutic applications of these molecules.
基金National Natural Sciences Foundation of China(Grant No.30672599)
文摘The extraction and solvent fi＇actionation of red alga Symphyocladia latiuscula, and repeated column chromatography led to isolation of 17 compounds： cholesterol （1）, 313,5β-dihydroxy-B-norcholestan-6βcarboxaldehyde （2）, 6β-hydroxy-cholest-4-ene- 3-one （3）, 1-O-myristoyl-3-O-（6＇-sulfo-α-D-quinovopyranosyl）glycerol （4）, 1-O-palmitoyl-3-O-（6＇-sulfo-u-19-quinovopyranosyl） glycerol （5）, 1-O-palmitoyl-3-O-[α-D-galactopyranosyl（1→6）β-D-galactopyranosyl] glycerol （6）, 1-O-palmitoyl-3-O-β-D- galactopyranosylglycerol （7）, methyl hexadecanoate （8）, methyl stearate （9）, hexadecanoic acid （10）, γ-n-butyl cis-aconiate （11）, α-n-Butyl cis-aconiate （12）, phenethylamine （13）, 3,5-dibromo-L-tyrosine （14）, 3-methylbutylamine （15）, methyl pyroglutamate （16）, n-butyl pyroglutamate （17）. The structures of these compounds were identified by NMR spectroscopy and mass spectrometry, and compared with those reported in the literature. All the compounds were isolated from Symphyocladia genus for the first time. These compounds were investigated for their inhibitory effects on human recombinant aldose reductase in vitro. Of the compounds, 1-O-palmitoyl-3-O-β-D-galactopyranosylglycerol （7） demonstrated moderate enzyme inhibition.
