Monosodium glutamate (MSG) was administrated to rats at doses of 0.6 and 1.6 mg/g body weight for 14 days. Body weight and relative liver and kidney weight of rats were significantly increased. On regard to liver func...Monosodium glutamate (MSG) was administrated to rats at doses of 0.6 and 1.6 mg/g body weight for 14 days. Body weight and relative liver and kidney weight of rats were significantly increased. On regard to liver functions, the activities of alanine aminotransferase (ALT) and γ glutamyle transferase (GGT) significantly increased in the serum, on MSG administration, meanwhile, serum total protein, albumin and serum total bilirubin significantly decreased. MSG had adverse effects on kidney functions as serum urea and serum creatinine were significantly increased. Vitamin C (0.3 mg/g body weight) and vitamin E (0.2 mg/g body weight) co-adminstrated with MSG, significantly restored the body weight and relative liver and kidney weights to control levels. In the presence of vitamin C and vitamin E the activities of ALT and GGT in the serum were also significantly reduced to become comparable with control trail. Consequently, serum total protein, albumin and serum total bilirubin were significantly increased in the serum, while serum urea and serum creatinine were significantly decreased after administration of each vitamin. The results showed that MSG at doses of 0.6 and 1.6 mg/g of body weight may cause an adverse effect on the hepatic and renal functions which might be due to oxidative stress induced by MSG on the liver and renal tissue. Supplementation of vitamin C and vitamin E was capable of ameliorating MSG-induced oxidative stress on hepatic and renal functions.展开更多
文摘目的观察陇中消肿止痛合剂对骨筋膜室综合征(OCS)患者视觉模拟评分法(VAS)评分及相关实验室指标的影响。方法采用随机数字表法将100例OCS患者分为对照组和治疗组各50例。对照组予20%甘露醇250 mL,七叶皂苷钠20 mg+生理盐水250 mL,均每日1次,静脉滴注。治疗组在对照组基础上予陇中消肿止痛合剂,每次50 mL,每日3次,口服。均1周为1个疗程,连续治疗2个疗程。比较2组治疗前及治疗3、7、14 d VAS评分及血清肌酸激酶(CK)、乳酸脱氢酶(LDH)、天冬氨酸氨基转移酶(AST)水平。结果与本组治疗前比较,2组治疗3、7、14 d VAS评分明显降低(P<0.05);2组治疗后比较,治疗组治疗3、7 d VAS评分明显低于对照组(P<0.05)。与本组治疗前比较,治疗3、7、14 d,2组血清CK、LDH、AST水平明显降低(P<0.01);2组治疗7、14 d比较,治疗组CK、LDH、AST水平改善明显优于对照组(P<0.05)。结论陇中消肿止痛合剂治疗OCS患者可有效止痛,降低患者血清CK、LDH、AST水平。
文摘Monosodium glutamate (MSG) was administrated to rats at doses of 0.6 and 1.6 mg/g body weight for 14 days. Body weight and relative liver and kidney weight of rats were significantly increased. On regard to liver functions, the activities of alanine aminotransferase (ALT) and γ glutamyle transferase (GGT) significantly increased in the serum, on MSG administration, meanwhile, serum total protein, albumin and serum total bilirubin significantly decreased. MSG had adverse effects on kidney functions as serum urea and serum creatinine were significantly increased. Vitamin C (0.3 mg/g body weight) and vitamin E (0.2 mg/g body weight) co-adminstrated with MSG, significantly restored the body weight and relative liver and kidney weights to control levels. In the presence of vitamin C and vitamin E the activities of ALT and GGT in the serum were also significantly reduced to become comparable with control trail. Consequently, serum total protein, albumin and serum total bilirubin were significantly increased in the serum, while serum urea and serum creatinine were significantly decreased after administration of each vitamin. The results showed that MSG at doses of 0.6 and 1.6 mg/g of body weight may cause an adverse effect on the hepatic and renal functions which might be due to oxidative stress induced by MSG on the liver and renal tissue. Supplementation of vitamin C and vitamin E was capable of ameliorating MSG-induced oxidative stress on hepatic and renal functions.
基金the National Natural Science Foundation of China(No.81571888)the Program on Key Basic Research Project of PLA Commission of Science and Technology and the Fund for Talent Training of Army Medical Center(No.2019CXJSB022)。
