OBJECTIVE: To investigate the effects of long-term exposure to moxa smoke on acupuncturists and to consider the association between physical symptoms and gender, age, secondhand smoke(SHS) exposure, and the duration o...OBJECTIVE: To investigate the effects of long-term exposure to moxa smoke on acupuncturists and to consider the association between physical symptoms and gender, age, secondhand smoke(SHS) exposure, and the duration of exposure.METHODS: A self-report, web-based questionnaire was used to evaluate the effects of moxa smoke onacupuncturists. Logistic regression was used to analyze the relationship between physical symptoms and possible correlative factors.RESULTS: A total of 858 questionnaires were analyzed. The data showed that 42.42% of acupuncturists had been exposed to moxa smoke for 5-10 years. The most frequent symptom was tearing(32.98%) and the least frequent symptom was asthma(5.24%). Logistic regression analysis showed that female acupuncturists were slightly more susceptible to cough and tearing than males(cough:OR: 1.583, 95% CI: 1.079, 2.321, P = 0.019; tearing:OR: 1.519, 95% CI: 1.094, 2.108, P = 0.013). Acupuncturists aged over 25 years reported a slightly lower incidence of eye itchiness than those aged under25 years(26-40 years: OR: 0.604, 95% CI: 0.379,0.965, P = 0.035; over 40 years: OR: 0.330, 95% CI:0.114, 0.958, P = 0.042). Ophthalmodynia occurred less in acupuncturists aged 26-40 years(OR: 0.591,95% CI: 0.359, 0.970, P = 0.038) than in those younger than 25 years. The only association between prevalence of symptoms and tobacco use and SHS exposure was that smokers had a lower occurrence of phlegm in the throat(OR: 0.579, 95% CI: 0.392,0.856, P = 0.006). Shortness of breath was less frequent in participants exposed to moxa smoke for more than 5 years(5-10 years: OR: 0.400, 95% CI:0.204, 0.785, P = 0.008; 11-20 years: OR: 0.392, 95%CI: 0.178, 0.864, P = 0.02), but a slightly higher incidence of eye itchiness was found in those with over20 years of moxa exposure(OR: 4.200, 95% CI:1.344, 3.128, P = 0.014).CONCLUSION: The most frequent symptom of moxa smoke exposure in acupuncturists was tear-ing. The association of symptoms with age and duration of exposure to moxa smoke were rather complicated; h展开更多
<strong>Objective:</strong> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">DNA copy number alterati...<strong>Objective:</strong> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">DNA copy number alterations and difference expression are frequently observed in ovarian cancer. The purpose of this way was to pinpoint gene expression change that w</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">as</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> associated with alterations in DNA copy number and could therefore enlighten some potential oncogenes and stability genes with functional roles in cancers, and investigated the bioinformatics significance for those correlated genes</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">. </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Method: </span></b></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">We obtained the DNA copy </span><span style="font-family:Verdana;">number and mRNA expression data from the Cancer Genomic Atlas and</span><span style="font-family:Verdana;"> identified the most statistically significant copy number alteration regions using the GISTIC. Then identified the significance genes between the tumor samples within the copy number alteration regions and analyzed the correlation using a binary matrix. The selected genes were subjected to bio</span><span><span style="font-family:Verdana;">informatics analysis using GSEA tool. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> GISTIC analysis results</span></span><span style="font-family:Verdana;"> showed there were 45 significance copy number amplification regions in the ovarian cancer, SAM and Fisher’s exact test found there have 40 genes can affect the expressi展开更多
Pitting corrosion and crevice corrosion behaviors of high nitrogen austenitic stainless steels （HNSS） were investigated by electrochemical and immersion testing methods in chloride solution, respectively. The chemic...Pitting corrosion and crevice corrosion behaviors of high nitrogen austenitic stainless steels （HNSS） were investigated by electrochemical and immersion testing methods in chloride solution, respectively. The chemical constitution and composition in the depth of passive films formed on HNSS were analyzed by X-ray photoelectron spectrum （XPS）. HNSS has excellent pitting and crevice corrosion resistance compared to 316L stainless steel. With increasing the nitrogen content in steels, pitting potentials and critical pitting temperature （CPT） increase, and the maximum, average pit depths and average weight loss decrease. The CPT of HNSS is correlated with the alloying element content through the measure of alloying for resistance to corrosion （MARC）. The MARC can be expressed as an equation of CPT=2.55MARC-29. XPS results show that HNSS exhibiting excellent corrosion resistance is attributed to the enrichment of nitrogen on the surface of passive films, which forms ammonium ions increasing the local pH value and facilitating repassivation, and the synergistic effects of molybdenum and nitrogen.展开更多
目的:构建复杂性肛瘘术后并发肛门失禁的风险预测模型并进行效果评价。方法:回顾性分析2020年1月至2021年5月福建中医药大学附属人民医院肛肠科收治的195例复杂性肛瘘患者资料。根据术后肛门失禁症状,将CCFIS评分≥2分划为肛门失禁组(42...目的:构建复杂性肛瘘术后并发肛门失禁的风险预测模型并进行效果评价。方法:回顾性分析2020年1月至2021年5月福建中医药大学附属人民医院肛肠科收治的195例复杂性肛瘘患者资料。根据术后肛门失禁症状,将CCFIS评分≥2分划为肛门失禁组(42例),CCFIS评分<2分划为功能正常组(153例)。结合患者一般情况、瘘管性质、肛门直肠压力测定结果、手术方式等变量进行单因素及logistic回归分析。结果:术后肛门失禁发生率为21.54%,CCFIS平均分为(3.40±1.170)分。logistic回归分析结果显示,瘘管类型为括约肌上瘘(OR=1.024,95%CI=0.405~2.585,P=0.025)、既往有1次以上的瘘管手术(OR=16.224,95%CI=3.291~29.977,P=0.001)、低静息压(OR=0.909,95%CI=0.869~0.952,P=0.000)、手术方式为切割挂线术(OR=1.389,95%CI=1.044~1.848,P=0.024)是复杂性肛瘘术后并发肛门失禁的独立危险因素(P<0.05)。根据筛选出的独立危险因素构建预测模型,绘制受试者工作特征(receiver operating characteristic,ROC)曲线,曲线下面积(area under the curve,AUC)为0.879(95%CI=0.818~0.939,P<0.001),提示该模型有较好的预测价值。结论:通过独立危险因素建立的预测模型准确度较高,为临床复杂性肛瘘治疗方案的制订提供较好的参考依据。展开更多
基金Supported by the National Basic Research Program of China(973 Program,No.2015CB554504)
文摘OBJECTIVE: To investigate the effects of long-term exposure to moxa smoke on acupuncturists and to consider the association between physical symptoms and gender, age, secondhand smoke(SHS) exposure, and the duration of exposure.METHODS: A self-report, web-based questionnaire was used to evaluate the effects of moxa smoke onacupuncturists. Logistic regression was used to analyze the relationship between physical symptoms and possible correlative factors.RESULTS: A total of 858 questionnaires were analyzed. The data showed that 42.42% of acupuncturists had been exposed to moxa smoke for 5-10 years. The most frequent symptom was tearing(32.98%) and the least frequent symptom was asthma(5.24%). Logistic regression analysis showed that female acupuncturists were slightly more susceptible to cough and tearing than males(cough:OR: 1.583, 95% CI: 1.079, 2.321, P = 0.019; tearing:OR: 1.519, 95% CI: 1.094, 2.108, P = 0.013). Acupuncturists aged over 25 years reported a slightly lower incidence of eye itchiness than those aged under25 years(26-40 years: OR: 0.604, 95% CI: 0.379,0.965, P = 0.035; over 40 years: OR: 0.330, 95% CI:0.114, 0.958, P = 0.042). Ophthalmodynia occurred less in acupuncturists aged 26-40 years(OR: 0.591,95% CI: 0.359, 0.970, P = 0.038) than in those younger than 25 years. The only association between prevalence of symptoms and tobacco use and SHS exposure was that smokers had a lower occurrence of phlegm in the throat(OR: 0.579, 95% CI: 0.392,0.856, P = 0.006). Shortness of breath was less frequent in participants exposed to moxa smoke for more than 5 years(5-10 years: OR: 0.400, 95% CI:0.204, 0.785, P = 0.008; 11-20 years: OR: 0.392, 95%CI: 0.178, 0.864, P = 0.02), but a slightly higher incidence of eye itchiness was found in those with over20 years of moxa exposure(OR: 4.200, 95% CI:1.344, 3.128, P = 0.014).CONCLUSION: The most frequent symptom of moxa smoke exposure in acupuncturists was tear-ing. The association of symptoms with age and duration of exposure to moxa smoke were rather complicated; h
文摘<strong>Objective:</strong> <span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">DNA copy number alterations and difference expression are frequently observed in ovarian cancer. The purpose of this way was to pinpoint gene expression change that w</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">as</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> associated with alterations in DNA copy number and could therefore enlighten some potential oncogenes and stability genes with functional roles in cancers, and investigated the bioinformatics significance for those correlated genes</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">. </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><b><span style="font-family:Verdana;">Method: </span></b></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">We obtained the DNA copy </span><span style="font-family:Verdana;">number and mRNA expression data from the Cancer Genomic Atlas and</span><span style="font-family:Verdana;"> identified the most statistically significant copy number alteration regions using the GISTIC. Then identified the significance genes between the tumor samples within the copy number alteration regions and analyzed the correlation using a binary matrix. The selected genes were subjected to bio</span><span><span style="font-family:Verdana;">informatics analysis using GSEA tool. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> GISTIC analysis results</span></span><span style="font-family:Verdana;"> showed there were 45 significance copy number amplification regions in the ovarian cancer, SAM and Fisher’s exact test found there have 40 genes can affect the expressi
基金supported by the National Natural Science Foundation of China and Baosteel Group Corporation (No.50534010)
文摘Pitting corrosion and crevice corrosion behaviors of high nitrogen austenitic stainless steels （HNSS） were investigated by electrochemical and immersion testing methods in chloride solution, respectively. The chemical constitution and composition in the depth of passive films formed on HNSS were analyzed by X-ray photoelectron spectrum （XPS）. HNSS has excellent pitting and crevice corrosion resistance compared to 316L stainless steel. With increasing the nitrogen content in steels, pitting potentials and critical pitting temperature （CPT） increase, and the maximum, average pit depths and average weight loss decrease. The CPT of HNSS is correlated with the alloying element content through the measure of alloying for resistance to corrosion （MARC）. The MARC can be expressed as an equation of CPT=2.55MARC-29. XPS results show that HNSS exhibiting excellent corrosion resistance is attributed to the enrichment of nitrogen on the surface of passive films, which forms ammonium ions increasing the local pH value and facilitating repassivation, and the synergistic effects of molybdenum and nitrogen.
文摘目的:构建复杂性肛瘘术后并发肛门失禁的风险预测模型并进行效果评价。方法:回顾性分析2020年1月至2021年5月福建中医药大学附属人民医院肛肠科收治的195例复杂性肛瘘患者资料。根据术后肛门失禁症状,将CCFIS评分≥2分划为肛门失禁组(42例),CCFIS评分<2分划为功能正常组(153例)。结合患者一般情况、瘘管性质、肛门直肠压力测定结果、手术方式等变量进行单因素及logistic回归分析。结果:术后肛门失禁发生率为21.54%,CCFIS平均分为(3.40±1.170)分。logistic回归分析结果显示,瘘管类型为括约肌上瘘(OR=1.024,95%CI=0.405~2.585,P=0.025)、既往有1次以上的瘘管手术(OR=16.224,95%CI=3.291~29.977,P=0.001)、低静息压(OR=0.909,95%CI=0.869~0.952,P=0.000)、手术方式为切割挂线术(OR=1.389,95%CI=1.044~1.848,P=0.024)是复杂性肛瘘术后并发肛门失禁的独立危险因素(P<0.05)。根据筛选出的独立危险因素构建预测模型,绘制受试者工作特征(receiver operating characteristic,ROC)曲线,曲线下面积(area under the curve,AUC)为0.879(95%CI=0.818~0.939,P<0.001),提示该模型有较好的预测价值。结论:通过独立危险因素建立的预测模型准确度较高,为临床复杂性肛瘘治疗方案的制订提供较好的参考依据。
