BACKGROUND Ischemic stroke is an entity with high incidence,morbidity,and mortality rates.Carotid artery stenosis is an important and independent risk factor for ischemic stroke.The three current approaches for treati...BACKGROUND Ischemic stroke is an entity with high incidence,morbidity,and mortality rates.Carotid artery stenosis is an important and independent risk factor for ischemic stroke.The three current approaches for treating carotid artery stenosis are drug treatment,carotid endarterectomy(CEA),carotid angioplasty and stenting(CAS).The approach is chosen based on the degree of stenosis.CEA or CAS could have been chosen for the current patient,who had severe carotid stenosis and an iodinated contrast allergy.After thoroughly communicating with the patient,the patient chose CAS for treatment.Therefore,we performed ultrasound-guided CAS to avoid the use of iodinated contrast.CASE SUMMARY The main symptoms of the patient were numbness and weakness of the left limb.Computed tomography angiography of the head and neck at another hospital indicated multiple sites of stenosis in the arteries of the head and neck.The patient requested CAS for treatment but was allergic to iodinated contrast media.Thus,routine digital subtraction angiography(DSA)with iodinated contrast could not be used for the procedure.The diagnosis of this patient was as follows:(1)Right parietal lobe cerebral infarction;(2)multiple sites of stenosis in the arteries of the head and neck(severe stenosis of the right internal carotid artery,severe stenosis of the right subclavian artery);(3)right subclavian steal syndrome;and(4)hypertension(stage 3,high risk).The interventions included routine treatment for cerebral infarction,oral administration of clopidogrel(75 mg qd)and aspirin(100 mg qd),ultrasound-guided CAS,and postoperative follow-up.Postoperative color Doppler ultrasound and cerebrovascular magnetic resonance angiography of the carotid artery showed good vascular recovery,and the postoperative follow-up indicated a good prognosis.CONCLUSION This case study suggests that ultrasound-guided endovascular treatment is a potential option for patients with contraindications to the iodinated contrast agents used in DSA-guided surgery,although excellent surgic展开更多
Smart magnetic resonance imaging(MRI) contrast agent has the ability to increase or decrease the signal intensity through response to certain analyte. Among the growing class of responsive agent, imaging probes based ...Smart magnetic resonance imaging(MRI) contrast agent has the ability to increase or decrease the signal intensity through response to certain analyte. Among the growing class of responsive agent, imaging probes based on gadolinium ion are developing fast in the last decade since they play an important role in physiological and pathology process in living system. This minireview would highlight recent progress in metal responsive gadolinium-based MRI contrast agent.展开更多
Gadolinium(Ⅲ)-based T_(1) contrast agents have been widely used in clinical MRI.In this study,salicylic acid-gadolinium chelate was prepared via directly coordination reaction of gadolinium ion and salicylic acid.The...Gadolinium(Ⅲ)-based T_(1) contrast agents have been widely used in clinical MRI.In this study,salicylic acid-gadolinium chelate was prepared via directly coordination reaction of gadolinium ion and salicylic acid.Then,three polyethylene glycols with different molecular weight were modified on the surface of salicylic acid-gadolinium by simple chemical coupling to construct three core-shell structural Gd based composites.The scanning electron microscopy(SEM)and transmission electron microscopy(TEM)characterization results show that the composite is a spherical particle with a diameter of about 100-200 nm.The longitudinal relaxation rate r_(1) of the Gal-PEG-2000 is 11.097(mmol/L)^(-1)/s,and the ratio of r_(2)/r_(1) is as low as 2.53.The composite shows good liver and intestines MRI performances after being used in in vivo imaging,showing a good prospect of biological application.展开更多
Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of the...Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of these Gd (Ⅲ) complexes was chosen for the acute toxicity test and T_1-weighted imagingmeasurement. Preliminary results showed that. compared with Gd-DTPA. the neutral macromoleculargadolinium (Ⅲ) complexes provide higher T_1 relaxivity enhancement and longer function duration.展开更多
The relaxivities of two gadolinium heteropoly complexes β K 17 [(GdO) 3(SiW 9O 34 ) 2]·20H 2O and K 13 [Gd(GeW 11 O 39 ) 2]·20H 2O in aqueous solution have been measured. Their relaxivities are 16.27 and 16...The relaxivities of two gadolinium heteropoly complexes β K 17 [(GdO) 3(SiW 9O 34 ) 2]·20H 2O and K 13 [Gd(GeW 11 O 39 ) 2]·20H 2O in aqueous solution have been measured. Their relaxivities are 16.27 and 16.41 mmol -1 ·s -1 ·L, respectively. The results indicate that the two gadolinium heteropoly complexes may be potential contrast agents for MRI. [WT5HZ]展开更多
Synthesis and characterization of NMR T-1 relaxation properties of the title complexes and several transition metal-EDTA-bis[ tris(hydroxymethyl methylamide] complexes were performed for searching new contrast agents ...Synthesis and characterization of NMR T-1 relaxation properties of the title complexes and several transition metal-EDTA-bis[ tris(hydroxymethyl methylamide] complexes were performed for searching new contrast agents for magnetic resonance imaging(MRI). The ligands, abbr. to DTPA-BTris and EDTA-BTris, were obtained by modifying DTPA and EDTA with tris(hydroxymethyl) aminomethane. It was found that the relaxivities of solutions of the modified complexes in vitro are correspondingly greater than those of the parent complexes. For GdDTPA-BTris, MnEDTA-BTris, and FeEDTA-BTris, the relaxometry of lattice relaxation(R-1) is 5.4, 3.1, and 1.9 L.mmol(-1).s(-1) vs. 5.2, 2.8 and 1.7 L.mmol(-1).s(-1) for GdDTPA, MnEDTA, and FeEDTA, respectively. Additionally, the present complexes have the favorable properties such as high water solubility and chemical stability required of clinical useful contrast agent.展开更多
基金Supported by the Foundation of the Longhua District Health System Project Cooperation 2022(basic and clinical research in ischemic stroke).
文摘BACKGROUND Ischemic stroke is an entity with high incidence,morbidity,and mortality rates.Carotid artery stenosis is an important and independent risk factor for ischemic stroke.The three current approaches for treating carotid artery stenosis are drug treatment,carotid endarterectomy(CEA),carotid angioplasty and stenting(CAS).The approach is chosen based on the degree of stenosis.CEA or CAS could have been chosen for the current patient,who had severe carotid stenosis and an iodinated contrast allergy.After thoroughly communicating with the patient,the patient chose CAS for treatment.Therefore,we performed ultrasound-guided CAS to avoid the use of iodinated contrast.CASE SUMMARY The main symptoms of the patient were numbness and weakness of the left limb.Computed tomography angiography of the head and neck at another hospital indicated multiple sites of stenosis in the arteries of the head and neck.The patient requested CAS for treatment but was allergic to iodinated contrast media.Thus,routine digital subtraction angiography(DSA)with iodinated contrast could not be used for the procedure.The diagnosis of this patient was as follows:(1)Right parietal lobe cerebral infarction;(2)multiple sites of stenosis in the arteries of the head and neck(severe stenosis of the right internal carotid artery,severe stenosis of the right subclavian artery);(3)right subclavian steal syndrome;and(4)hypertension(stage 3,high risk).The interventions included routine treatment for cerebral infarction,oral administration of clopidogrel(75 mg qd)and aspirin(100 mg qd),ultrasound-guided CAS,and postoperative follow-up.Postoperative color Doppler ultrasound and cerebrovascular magnetic resonance angiography of the carotid artery showed good vascular recovery,and the postoperative follow-up indicated a good prognosis.CONCLUSION This case study suggests that ultrasound-guided endovascular treatment is a potential option for patients with contraindications to the iodinated contrast agents used in DSA-guided surgery,although excellent surgic
基金supported by the Scientific Instrument Developing Project of the Chinese Academy of Sciences(Grant No.ZDKYYQ20180001)the National Natural Science Foundation of China(Grant No.21704099)the CAS Pioneer Hundred Talents Program and the Open Funds of the State Key Laboratory of Rare Earth Resource Utilization(Grant No.RERUY2017009)
文摘Smart magnetic resonance imaging(MRI) contrast agent has the ability to increase or decrease the signal intensity through response to certain analyte. Among the growing class of responsive agent, imaging probes based on gadolinium ion are developing fast in the last decade since they play an important role in physiological and pathology process in living system. This minireview would highlight recent progress in metal responsive gadolinium-based MRI contrast agent.
基金Project supported by the Natural Science Foundation of Gansu Province(20JR10RA511,2019B-084)。
文摘Gadolinium(Ⅲ)-based T_(1) contrast agents have been widely used in clinical MRI.In this study,salicylic acid-gadolinium chelate was prepared via directly coordination reaction of gadolinium ion and salicylic acid.Then,three polyethylene glycols with different molecular weight were modified on the surface of salicylic acid-gadolinium by simple chemical coupling to construct three core-shell structural Gd based composites.The scanning electron microscopy(SEM)and transmission electron microscopy(TEM)characterization results show that the composite is a spherical particle with a diameter of about 100-200 nm.The longitudinal relaxation rate r_(1) of the Gal-PEG-2000 is 11.097(mmol/L)^(-1)/s,and the ratio of r_(2)/r_(1) is as low as 2.53.The composite shows good liver and intestines MRI performances after being used in in vivo imaging,showing a good prospect of biological application.
基金Project supported by the Chinese Academy of Sciences and the State Sciences and Technology Commission of China.
文摘Five neutral macromolecular polyester gadolinium (Ⅲ) complexes with pendant hydrophobic alkyland aromatic functional groups were prepared. The longitudinal relaxation rates of these complexes weremeasured. One of these Gd (Ⅲ) complexes was chosen for the acute toxicity test and T_1-weighted imagingmeasurement. Preliminary results showed that. compared with Gd-DTPA. the neutral macromoleculargadolinium (Ⅲ) complexes provide higher T_1 relaxivity enhancement and longer function duration.
文摘The relaxivities of two gadolinium heteropoly complexes β K 17 [(GdO) 3(SiW 9O 34 ) 2]·20H 2O and K 13 [Gd(GeW 11 O 39 ) 2]·20H 2O in aqueous solution have been measured. Their relaxivities are 16.27 and 16.41 mmol -1 ·s -1 ·L, respectively. The results indicate that the two gadolinium heteropoly complexes may be potential contrast agents for MRI. [WT5HZ]
文摘Synthesis and characterization of NMR T-1 relaxation properties of the title complexes and several transition metal-EDTA-bis[ tris(hydroxymethyl methylamide] complexes were performed for searching new contrast agents for magnetic resonance imaging(MRI). The ligands, abbr. to DTPA-BTris and EDTA-BTris, were obtained by modifying DTPA and EDTA with tris(hydroxymethyl) aminomethane. It was found that the relaxivities of solutions of the modified complexes in vitro are correspondingly greater than those of the parent complexes. For GdDTPA-BTris, MnEDTA-BTris, and FeEDTA-BTris, the relaxometry of lattice relaxation(R-1) is 5.4, 3.1, and 1.9 L.mmol(-1).s(-1) vs. 5.2, 2.8 and 1.7 L.mmol(-1).s(-1) for GdDTPA, MnEDTA, and FeEDTA, respectively. Additionally, the present complexes have the favorable properties such as high water solubility and chemical stability required of clinical useful contrast agent.
