适应新一代智能变电站对二次设备功能一体化的要求,对集成保护控制功能的智能变电站一体化智能终端进行研究。结合间隔层和过程层二次设备的工程配置,对一体化智能终端的接口标准化、功能整合、信息共享、整装置的即插即用、软硬件集成...适应新一代智能变电站对二次设备功能一体化的要求,对集成保护控制功能的智能变电站一体化智能终端进行研究。结合间隔层和过程层二次设备的工程配置,对一体化智能终端的接口标准化、功能整合、信息共享、整装置的即插即用、软硬件集成以及可靠性设计等进行研究。依托新一代智能变电站层次化保护系统体系架构,提出一种实现间隔功能自治的一体化装置设计方案。采用多CPU信息融合与高速交互技术,在一套装置中集成了合并单元、智能终端、测控和保护装置的功能。基于紧凑型设计原则开发了适用于220 k V线路间隔的智能变电站控制保护一体化智能终端样机。通过测试验证,表明方案能减少二次设备数量,简化智能变电站系统架构。展开更多
Background and Aims:Functional cure(FC)is characterized by the clearance of the hepatitis B surface antigen from the serum of patients with chronic hepatitis B(CHB).However,the level of intrahepatic covalently closed ...Background and Aims:Functional cure(FC)is characterized by the clearance of the hepatitis B surface antigen from the serum of patients with chronic hepatitis B(CHB).However,the level of intrahepatic covalently closed circular DNA(cccDNA)and hepatitis B virus(HBV)integration remains unclear.We conducted this study to determine them and reveal their value in the treatment of CHB.Methods:There were two sessions to elucidate the changes in intrahepatic cccDNA and HBV integration after antiviral therapy.In the first session,116 patients were enrolled and divided into FC,non-functional cure(NFC),and CHB groups,including 48 patients with functionally cured CHB,27 with CHB without functional cure after antiviral treatment,and 41 with treatment-naïve CHB.Patients were tested for both intrahepatic cccDNA and other viral markers.All patients in the FC group were followed up for at least 24 weeks to observe relapse.In the second session,another ten patients were included for in-depth whole-genome sequencing to analyze HBV integration.Results:Thirteen patients in the FC group were negative for intrahepatic cccDNA.Intrahepatic cccDNA was much higher in the CHB group compared with the FC group.Seven patients had HBsAg seroreversion,including two with virological relapse.Integration of HBV was detected in one(33.3%)functionally cured patients and in seven(100%)with CHB.28.0%of the HBV breakpoints were assigned in the 1,500 nt to 1,900 nt range of the HBV genome.Conclusions:After achieving an FC,the rate of intrahepatic cccDNA and HBV integration was significantly reduced in patients with CHB.For those patients who cleared intrahepatic cccDNA,the chances of developing virological relapse were even lower.展开更多
文摘适应新一代智能变电站对二次设备功能一体化的要求,对集成保护控制功能的智能变电站一体化智能终端进行研究。结合间隔层和过程层二次设备的工程配置,对一体化智能终端的接口标准化、功能整合、信息共享、整装置的即插即用、软硬件集成以及可靠性设计等进行研究。依托新一代智能变电站层次化保护系统体系架构,提出一种实现间隔功能自治的一体化装置设计方案。采用多CPU信息融合与高速交互技术,在一套装置中集成了合并单元、智能终端、测控和保护装置的功能。基于紧凑型设计原则开发了适用于220 k V线路间隔的智能变电站控制保护一体化智能终端样机。通过测试验证,表明方案能减少二次设备数量,简化智能变电站系统架构。
基金The National Science and Technology Major Project (2018ZX10302204-002)the National Natural Science Foundation of China (81672701).
文摘Background and Aims:Functional cure(FC)is characterized by the clearance of the hepatitis B surface antigen from the serum of patients with chronic hepatitis B(CHB).However,the level of intrahepatic covalently closed circular DNA(cccDNA)and hepatitis B virus(HBV)integration remains unclear.We conducted this study to determine them and reveal their value in the treatment of CHB.Methods:There were two sessions to elucidate the changes in intrahepatic cccDNA and HBV integration after antiviral therapy.In the first session,116 patients were enrolled and divided into FC,non-functional cure(NFC),and CHB groups,including 48 patients with functionally cured CHB,27 with CHB without functional cure after antiviral treatment,and 41 with treatment-naïve CHB.Patients were tested for both intrahepatic cccDNA and other viral markers.All patients in the FC group were followed up for at least 24 weeks to observe relapse.In the second session,another ten patients were included for in-depth whole-genome sequencing to analyze HBV integration.Results:Thirteen patients in the FC group were negative for intrahepatic cccDNA.Intrahepatic cccDNA was much higher in the CHB group compared with the FC group.Seven patients had HBsAg seroreversion,including two with virological relapse.Integration of HBV was detected in one(33.3%)functionally cured patients and in seven(100%)with CHB.28.0%of the HBV breakpoints were assigned in the 1,500 nt to 1,900 nt range of the HBV genome.Conclusions:After achieving an FC,the rate of intrahepatic cccDNA and HBV integration was significantly reduced in patients with CHB.For those patients who cleared intrahepatic cccDNA,the chances of developing virological relapse were even lower.
