目的研究旨在探讨在DASH饮食(终止高血压膳食疗法,Dietary Approaches to Stop Hypertension)模式下对中老年高血压患者的血清炎症因子和内皮标志相关指标的影响。方法研究分析了87例常规饮食患者和90例DASH饮食患者的临床资料。比较两...目的研究旨在探讨在DASH饮食(终止高血压膳食疗法,Dietary Approaches to Stop Hypertension)模式下对中老年高血压患者的血清炎症因子和内皮标志相关指标的影响。方法研究分析了87例常规饮食患者和90例DASH饮食患者的临床资料。比较两组营养摄入量、血清炎症因子(TNF-α、IL-6、CRP、IL-1β、MCP-1)和内皮标志物(内皮素-1、一氧化氮、VCAM-1、ICAM-1)。并对其进行相关性分析。结果与普通饮食组相比,DASH饮食组患者的总热量、总脂肪、饱和脂肪酸和钠摄入量较低,钾摄入量较高。DASH饮食组TNF-α和MCP-1水平较低,IL-6和IL-1β水平较高。内皮功能指标显示,DASH饮食组一氧化氮升高,内皮素-1水平降低,差异有统计学意义。相关分析显示饮食成分与炎症标志物和内皮功能指标之间存在关联。结论研究为血清炎症因子和内皮功能指标用于评价DASH饮食对中老年高血压患者的影响提供了强有力的证据。展开更多
The milk thistle plant is one of the famous plants that have been gaining popularity for its therapeutic potential for centuries. Milk thistle seed oil (MTSO) has been subjected to extensive research. The fixed oil wa...The milk thistle plant is one of the famous plants that have been gaining popularity for its therapeutic potential for centuries. Milk thistle seed oil (MTSO) has been subjected to extensive research. The fixed oil was extracted from the seeds of Silybum marianum (L.) using petroleum ether as a solvent by a soxhlet device. GC-MS was used to identify the chemical composition of the oil. The antioxidant activity of MTSO was tested by the ABTS method, which showed the ability to inhibit lipid peroxidation. In addition, antimicrobial and antifungal investigations were examined. It proved that MTSO has an inhibitory effect against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli), and antifungal effects (Candida albicans). MTSO has a slightly higher effectiveness against fungi than bacteria. Moreover, the cytotoxic activities of the oil on hepatocellular and colorectal carcinoma were examined. MTSO has shown a moderate cytotoxic effect on the HCT-116 cell line and a weak effect on HePG-2. Whereas;in vivo study has been done on five diagnosed patients who have impaired liver function, and were recruited for the study. Their weight ranged from 100 ± 30 kg, their age range was between 39 - 50 years. Each patient was given ten drops of MTSO daily and added to a little water for a four-week study period. MTSO has effects to improve the function of the injured liver. The present work aims to study Milk thistle seed oil, for estimating its pharmacological properties for the liver. This study focused on showing the importance of milk thistle seed oil in our lives as a source of antioxidants, anti-bacterial and anti-fungal, and as an anti-cancer of the liver and colon. It also sheds light on its importance as a treatment for impaired liver, function and fatty liver, due to its improvement in all liver function markers, so it can be hired as an effective human therapy.展开更多
Objectives: Over the past two decades, a large interest in cardiac marker elevations has developed in endurance sports events. The intense effort is not without risk. We aimed to see if the relatively cardiospecific b...Objectives: Over the past two decades, a large interest in cardiac marker elevations has developed in endurance sports events. The intense effort is not without risk. We aimed to see if the relatively cardiospecific biomarkers could show the damage on cardiac muscle cells. Methods: Fourteen cyclists were recruited for an international race (177 km). We studied different cardiac biomarkers, renal function markers and blood cytology. The subjects were submitted to three blood test: one before (T0), one just after (T1) and the last one 3 hours after the race (T3). Results: Blood cytology markers, namely erythrocytes, hemoglobin, hematocrit, and average hemoglobin concentration, were found to evolve in a similar way. Renal function markers, such as creatinin, cystatin C and uric acid, showed a post effort increase that might be related to renal blood flow depletion during exercise. Cardiac and muscular markers were all increased at T1. Conclusions: Physiological stress induced by an international cycling race certainly has consequences on cardiac muscle cells. Fortunately, those blood concentration variations are more representative of a transitional state, due to an imbalance created by an intense aerobic effort maintained during several hours, rather than an irreversible injury.展开更多
Study Objectives: Migraine is a complex neurovascular disease and is believed to be due to a mixture of genetic and environmental factors. Study design: This was a cross-sectional observational prospective hospital ba...Study Objectives: Migraine is a complex neurovascular disease and is believed to be due to a mixture of genetic and environmental factors. Study design: This was a cross-sectional observational prospective hospital based study conducted on 100 participants. They were divided into two groups;Group A: 50 migrainous patients according to the criteria of the International Classification of Headache Disorders and Group B: 50 healthy subjects both groups were age and sex matched. All subjects underwent a full neurological and psychiatric examination. Full headache evaluation sheet used in headache outpatient clinic in Ain Shams University Hospitals and HIT-6? Headache Impact Test was used. Assay of serum level of N-acetyl-aspartate (NAA) as mitochondrial function marker was done. Results: There was no significant difference between both groups regarding gender, age or age group, marital state, education, residence and special habits. However, there was a statistical significant difference as regards family history of migraine more in patient group. In this study, serum NAA levels in migraine patients were significantly lower than in healthy controls. Decreased NAA level is generally believed to be a sign of reduced neuronal and glial mitochondrial function. Also, migraine with aura patients showed lower NAA levels when compared to migraine without aura subtypes. However, there was no significant correlation was found between NAA serum levels, and gender, age at onset, age group, type of aura, duration of the illness, type of onset of pain, frequent site of pain, time to max severity, severity of attack, and daily functions (social life, work, psychological wellbeing, sleep and cognition). Conclusions: Findings of this study indicate that NAA in serum may be a marker for neuronal dysfunction predisposing to migraine, probably related to the reduced mitochondria function.展开更多
文摘目的研究旨在探讨在DASH饮食(终止高血压膳食疗法,Dietary Approaches to Stop Hypertension)模式下对中老年高血压患者的血清炎症因子和内皮标志相关指标的影响。方法研究分析了87例常规饮食患者和90例DASH饮食患者的临床资料。比较两组营养摄入量、血清炎症因子(TNF-α、IL-6、CRP、IL-1β、MCP-1)和内皮标志物(内皮素-1、一氧化氮、VCAM-1、ICAM-1)。并对其进行相关性分析。结果与普通饮食组相比,DASH饮食组患者的总热量、总脂肪、饱和脂肪酸和钠摄入量较低,钾摄入量较高。DASH饮食组TNF-α和MCP-1水平较低,IL-6和IL-1β水平较高。内皮功能指标显示,DASH饮食组一氧化氮升高,内皮素-1水平降低,差异有统计学意义。相关分析显示饮食成分与炎症标志物和内皮功能指标之间存在关联。结论研究为血清炎症因子和内皮功能指标用于评价DASH饮食对中老年高血压患者的影响提供了强有力的证据。
文摘The milk thistle plant is one of the famous plants that have been gaining popularity for its therapeutic potential for centuries. Milk thistle seed oil (MTSO) has been subjected to extensive research. The fixed oil was extracted from the seeds of Silybum marianum (L.) using petroleum ether as a solvent by a soxhlet device. GC-MS was used to identify the chemical composition of the oil. The antioxidant activity of MTSO was tested by the ABTS method, which showed the ability to inhibit lipid peroxidation. In addition, antimicrobial and antifungal investigations were examined. It proved that MTSO has an inhibitory effect against Gram-positive bacteria (Staphylococcus aureus), Gram-negative bacteria (Escherichia coli), and antifungal effects (Candida albicans). MTSO has a slightly higher effectiveness against fungi than bacteria. Moreover, the cytotoxic activities of the oil on hepatocellular and colorectal carcinoma were examined. MTSO has shown a moderate cytotoxic effect on the HCT-116 cell line and a weak effect on HePG-2. Whereas;in vivo study has been done on five diagnosed patients who have impaired liver function, and were recruited for the study. Their weight ranged from 100 ± 30 kg, their age range was between 39 - 50 years. Each patient was given ten drops of MTSO daily and added to a little water for a four-week study period. MTSO has effects to improve the function of the injured liver. The present work aims to study Milk thistle seed oil, for estimating its pharmacological properties for the liver. This study focused on showing the importance of milk thistle seed oil in our lives as a source of antioxidants, anti-bacterial and anti-fungal, and as an anti-cancer of the liver and colon. It also sheds light on its importance as a treatment for impaired liver, function and fatty liver, due to its improvement in all liver function markers, so it can be hired as an effective human therapy.
文摘Objectives: Over the past two decades, a large interest in cardiac marker elevations has developed in endurance sports events. The intense effort is not without risk. We aimed to see if the relatively cardiospecific biomarkers could show the damage on cardiac muscle cells. Methods: Fourteen cyclists were recruited for an international race (177 km). We studied different cardiac biomarkers, renal function markers and blood cytology. The subjects were submitted to three blood test: one before (T0), one just after (T1) and the last one 3 hours after the race (T3). Results: Blood cytology markers, namely erythrocytes, hemoglobin, hematocrit, and average hemoglobin concentration, were found to evolve in a similar way. Renal function markers, such as creatinin, cystatin C and uric acid, showed a post effort increase that might be related to renal blood flow depletion during exercise. Cardiac and muscular markers were all increased at T1. Conclusions: Physiological stress induced by an international cycling race certainly has consequences on cardiac muscle cells. Fortunately, those blood concentration variations are more representative of a transitional state, due to an imbalance created by an intense aerobic effort maintained during several hours, rather than an irreversible injury.
文摘Study Objectives: Migraine is a complex neurovascular disease and is believed to be due to a mixture of genetic and environmental factors. Study design: This was a cross-sectional observational prospective hospital based study conducted on 100 participants. They were divided into two groups;Group A: 50 migrainous patients according to the criteria of the International Classification of Headache Disorders and Group B: 50 healthy subjects both groups were age and sex matched. All subjects underwent a full neurological and psychiatric examination. Full headache evaluation sheet used in headache outpatient clinic in Ain Shams University Hospitals and HIT-6? Headache Impact Test was used. Assay of serum level of N-acetyl-aspartate (NAA) as mitochondrial function marker was done. Results: There was no significant difference between both groups regarding gender, age or age group, marital state, education, residence and special habits. However, there was a statistical significant difference as regards family history of migraine more in patient group. In this study, serum NAA levels in migraine patients were significantly lower than in healthy controls. Decreased NAA level is generally believed to be a sign of reduced neuronal and glial mitochondrial function. Also, migraine with aura patients showed lower NAA levels when compared to migraine without aura subtypes. However, there was no significant correlation was found between NAA serum levels, and gender, age at onset, age group, type of aura, duration of the illness, type of onset of pain, frequent site of pain, time to max severity, severity of attack, and daily functions (social life, work, psychological wellbeing, sleep and cognition). Conclusions: Findings of this study indicate that NAA in serum may be a marker for neuronal dysfunction predisposing to migraine, probably related to the reduced mitochondria function.
