A new fully automatic ^40Ar/^39Ar laboratory with a Thermo Scientific ARGUS VI mass spectrometer has been established in China University of Geosciences （Wuhan）. We designed and developed a mini efficient preparatio...A new fully automatic ^40Ar/^39Ar laboratory with a Thermo Scientific ARGUS VI mass spectrometer has been established in China University of Geosciences （Wuhan）. We designed and developed a mini efficient preparation system （80 mL）, a CO2 laser for heating samples, a crusher for extracting fluid inclusions within K-poor minerals and an air reservoir （31 L） and pipette （0.1 mL） system. The ARGUS VI mass spectrometer is operated by the Qtegra Noble Gas software, which can control the peripheral accessories, such as pneumatic valves, CO2 laser and crusher through a PeriCon （peripheral controller）. The experimental procedures of atmospheric argon ana- lyses, ^40Ar/^39Ar dating by laser stepwise heating and by progressive crushing in vacuo, can be fully automatically performed. The weighted mean of atmospheric ^40Ar/^36Ar ratios is 302.22＋0.03 （1σ, MSWD=0.74, n=200）, indicating that air reservoir and pipette system and the whole instrument sys- tem are very stable. This laboratory is a successful pioneer example in China to establish a new no- ble gas laboratory with self-made peripheral accessories expect for the mass spectrometer.展开更多
目的应用全自动三维超声右室定量软件(3D Auto RV)评估系统性红斑狼疮(SLE)患者右室收缩功能,分析其与红细胞分布宽度(RDW)的相关性。方法选取我院风湿免疫科诊断为SLE的患者70例,根据超声心动图测得的肺动脉收缩压(PASP)将其分为PASP≤...目的应用全自动三维超声右室定量软件(3D Auto RV)评估系统性红斑狼疮(SLE)患者右室收缩功能,分析其与红细胞分布宽度(RDW)的相关性。方法选取我院风湿免疫科诊断为SLE的患者70例,根据超声心动图测得的肺动脉收缩压(PASP)将其分为PASP≤30 mmHg(1 mmHg=0.133 kPa)者34例(Ⅰ组),30 mmHg<PASP<50 mmHg者20例(Ⅱ组)、PASP≥50 mmHg者16例(Ⅲ组);另选同期健康志愿者25例为对照组。各组均行二维超声心动图检查获取左室射血分数(LVEF)、右室面积变化率(RVFAC)、三尖瓣环收缩期平面位移(TAPSE)、三尖瓣环收缩期峰值速度(S’);3D Auto RV获取右室舒张末期容积指数(EDVi)、收缩末期容积指数(ESVi)、右室每搏量(RVSV)、右室射血分数(RVEF)、右室游离壁纵向应变(RVFWLS)、室间隔纵向应变(SLS);实验室检查获取RDW。比较各组上述检查结果的差异。采用Spearman相关分析法分析右室收缩功能与RDW的相关性;采用多元线性回归分析筛选SLE患者右室收缩功能受损的独立影响因子。结果与对照组和Ⅰ、Ⅱ组比较,Ⅲ组RVFAC减低,EDVi、ESVi均增高,差异均有统计学意义(均P<0.05);与对照组和Ⅰ组比较,Ⅱ、Ⅲ组RVEF、RVFWLS均减低,差异均有统计学意义(均P<0.05);与Ⅰ组比较,Ⅱ、Ⅲ组SLS均减低,差异均有统计学意义(均P<0.05)。Ⅰ~Ⅲ组RDW均高于对照组,差异均有统计学意义(均P<0.05)。Spearman相关性分析显示,EDVi、ESVi与RDW均呈正相关(r=0.211、0.251,均P<0.05),RVEF、RVFWLS、SLS与RDW均呈负相关(r=-0.284、-0.247、-0.251,均P<0.05)。多元线性回归分析显示,RDW、PASP均为SLE患者右室收缩功能受损的独立影响因子(β=-0.704、-0.190,均P<0.05)。结论3D Auto RV可准确评估SLE患者早期右室收缩功能,且其与RDW呈负相关;RDW和PASP均为SLE患者右室收缩功能受损的独立影响因子。展开更多
基金financially supported by the National Natural Science Foundation of China (Nos. 41503053, 41630315, 41688103, and 91128203)
文摘A new fully automatic ^40Ar/^39Ar laboratory with a Thermo Scientific ARGUS VI mass spectrometer has been established in China University of Geosciences （Wuhan）. We designed and developed a mini efficient preparation system （80 mL）, a CO2 laser for heating samples, a crusher for extracting fluid inclusions within K-poor minerals and an air reservoir （31 L） and pipette （0.1 mL） system. The ARGUS VI mass spectrometer is operated by the Qtegra Noble Gas software, which can control the peripheral accessories, such as pneumatic valves, CO2 laser and crusher through a PeriCon （peripheral controller）. The experimental procedures of atmospheric argon ana- lyses, ^40Ar/^39Ar dating by laser stepwise heating and by progressive crushing in vacuo, can be fully automatically performed. The weighted mean of atmospheric ^40Ar/^36Ar ratios is 302.22＋0.03 （1σ, MSWD=0.74, n=200）, indicating that air reservoir and pipette system and the whole instrument sys- tem are very stable. This laboratory is a successful pioneer example in China to establish a new no- ble gas laboratory with self-made peripheral accessories expect for the mass spectrometer.
文摘目的应用全自动三维超声右室定量软件(3D Auto RV)评估系统性红斑狼疮(SLE)患者右室收缩功能,分析其与红细胞分布宽度(RDW)的相关性。方法选取我院风湿免疫科诊断为SLE的患者70例,根据超声心动图测得的肺动脉收缩压(PASP)将其分为PASP≤30 mmHg(1 mmHg=0.133 kPa)者34例(Ⅰ组),30 mmHg<PASP<50 mmHg者20例(Ⅱ组)、PASP≥50 mmHg者16例(Ⅲ组);另选同期健康志愿者25例为对照组。各组均行二维超声心动图检查获取左室射血分数(LVEF)、右室面积变化率(RVFAC)、三尖瓣环收缩期平面位移(TAPSE)、三尖瓣环收缩期峰值速度(S’);3D Auto RV获取右室舒张末期容积指数(EDVi)、收缩末期容积指数(ESVi)、右室每搏量(RVSV)、右室射血分数(RVEF)、右室游离壁纵向应变(RVFWLS)、室间隔纵向应变(SLS);实验室检查获取RDW。比较各组上述检查结果的差异。采用Spearman相关分析法分析右室收缩功能与RDW的相关性;采用多元线性回归分析筛选SLE患者右室收缩功能受损的独立影响因子。结果与对照组和Ⅰ、Ⅱ组比较,Ⅲ组RVFAC减低,EDVi、ESVi均增高,差异均有统计学意义(均P<0.05);与对照组和Ⅰ组比较,Ⅱ、Ⅲ组RVEF、RVFWLS均减低,差异均有统计学意义(均P<0.05);与Ⅰ组比较,Ⅱ、Ⅲ组SLS均减低,差异均有统计学意义(均P<0.05)。Ⅰ~Ⅲ组RDW均高于对照组,差异均有统计学意义(均P<0.05)。Spearman相关性分析显示,EDVi、ESVi与RDW均呈正相关(r=0.211、0.251,均P<0.05),RVEF、RVFWLS、SLS与RDW均呈负相关(r=-0.284、-0.247、-0.251,均P<0.05)。多元线性回归分析显示,RDW、PASP均为SLE患者右室收缩功能受损的独立影响因子(β=-0.704、-0.190,均P<0.05)。结论3D Auto RV可准确评估SLE患者早期右室收缩功能,且其与RDW呈负相关;RDW和PASP均为SLE患者右室收缩功能受损的独立影响因子。
