目的研究抗生素氟氯西林钠的关键中间体3-(2′-氯-6′-氟苯基)-5-甲基-4-异噁唑甲酰氯的合成方法,使之适合工业化生产。方法以2-氯-6-氟苯甲醛为原料,经肟化、氯化、环合、水解、酰氯化等步骤制得目标化合物。结果合成产物的化学结构经I...目的研究抗生素氟氯西林钠的关键中间体3-(2′-氯-6′-氟苯基)-5-甲基-4-异噁唑甲酰氯的合成方法,使之适合工业化生产。方法以2-氯-6-氟苯甲醛为原料,经肟化、氯化、环合、水解、酰氯化等步骤制得目标化合物。结果合成产物的化学结构经IR,1H-NMR,13C-NMR and MS确证,总收率为60.2%。结论此方法收率高,成本低,适合工业化生产。展开更多
目的观察剖宫产患者术后口服氟氯西林预防感染的效果。方法将剖宫产患者566例分为治疗组301例和对照组265例。治疗组术前30 m in内静脉注射头孢曲松1.0 g,术后给予口服氟氯西林胶囊0.5 g,b id,共5 d;对照组术前30 m in内静脉注射头孢曲...目的观察剖宫产患者术后口服氟氯西林预防感染的效果。方法将剖宫产患者566例分为治疗组301例和对照组265例。治疗组术前30 m in内静脉注射头孢曲松1.0 g,术后给予口服氟氯西林胶囊0.5 g,b id,共5 d;对照组术前30 m in内静脉注射头孢曲松1.0 g,术后给予静脉注射头孢曲松1.0 g,qd,共3 d。其他处理两组相同。比较两组产褥感染的情况。结果治疗组和对照组产褥感染分别为34,19例,差异无显著性(P>0.05),且均无严重不良反应。结论无感染的剖宫产术后患者可口服氟氯西林预防感染,减少全身用药对母婴的影响,降低医疗费用。展开更多
Objective: To achieve optimal effect with beta-lactam antibiotics, regimens with frequent dosages have been found necessary. However, if compliance is negatively influenced by more frequent dosages, this might hamper ...Objective: To achieve optimal effect with beta-lactam antibiotics, regimens with frequent dosages have been found necessary. However, if compliance is negatively influenced by more frequent dosages, this might hamper the effect of the treatments. Therefore, we have studied whether the numbers of daily dosages influence the compliance with prescribed flucloxacillin regimens. Design: A prospective interview study of patients with different dosing regimens of flucloxacillin. Setting: In the study, 200 patients with different dosing regimens of flucloxacillin underwent structured telephone interviews in order to reveal their compliance with the medication. Of these, 13 were prescribed twice-daily doses, 163 three times daily and 24 patients four times daily regimens. Results: There were no statistically significant differences between missed doses and prescribed numbers of daily doses. There was, however, a significant difference in the number of daily doses and experiences associated with the medication. Conclusions: This study shows that patients comply well with regimens of up to four daily doses of flucloxacillin, despite experiencing increasing difficulties with regimens of more frequent dosages.展开更多
文摘目的研究抗生素氟氯西林钠的关键中间体3-(2′-氯-6′-氟苯基)-5-甲基-4-异噁唑甲酰氯的合成方法,使之适合工业化生产。方法以2-氯-6-氟苯甲醛为原料,经肟化、氯化、环合、水解、酰氯化等步骤制得目标化合物。结果合成产物的化学结构经IR,1H-NMR,13C-NMR and MS确证,总收率为60.2%。结论此方法收率高,成本低,适合工业化生产。
文摘Objective: To achieve optimal effect with beta-lactam antibiotics, regimens with frequent dosages have been found necessary. However, if compliance is negatively influenced by more frequent dosages, this might hamper the effect of the treatments. Therefore, we have studied whether the numbers of daily dosages influence the compliance with prescribed flucloxacillin regimens. Design: A prospective interview study of patients with different dosing regimens of flucloxacillin. Setting: In the study, 200 patients with different dosing regimens of flucloxacillin underwent structured telephone interviews in order to reveal their compliance with the medication. Of these, 13 were prescribed twice-daily doses, 163 three times daily and 24 patients four times daily regimens. Results: There were no statistically significant differences between missed doses and prescribed numbers of daily doses. There was, however, a significant difference in the number of daily doses and experiences associated with the medication. Conclusions: This study shows that patients comply well with regimens of up to four daily doses of flucloxacillin, despite experiencing increasing difficulties with regimens of more frequent dosages.
