AIM:To report our experience of gastrointestinal stromal tumors (GISTs) during the last 29 years. METHODS:Thirty two cases of GIST referred to our Institution from the 1st January 1981 to the 10th June 2010 were revie...AIM:To report our experience of gastrointestinal stromal tumors (GISTs) during the last 29 years. METHODS:Thirty two cases of GIST referred to our Institution from the 1st January 1981 to the 10th June 2010 were reviewed. Metastases,recurrence and survival data were collected in relation to age,history,clinical presentation,location,size,resection margins and cellular features. RESULTS:Mean age was 63.7 years (range,40-90) and incidence was slightly higher in males (56%). R0 resection was performed in 90.7% of cases,R1 in 6.2% (2 cases) and R2 in 3.1% (one case). Using Fletcher's classification 8/32 (25%) had high risk,9/32 (28%) intermediate and 15/32 (47%) low risk tumors. Follow-up varied from 1 mo to 29 years,with a median of 8 years; overall survival was 75% (24/32),disease-free survival was 72% and tumor-related mortality was 9.3%. Three patients with high risk GIST were treated with imatinib mesylate:one developed a recurrence after 36 mo,and 2 are free from disease at 41 mo. CONCLUSION:Surgical treatment remains the gold standard therapy for resectable GISTs. Pathological and biological features of the neoplasm represent the most important factors predicting the prognosis.展开更多
Prekallikrein deficiency is a disorder that often remains undiagnosed. Prekallikrein activates factor XII, which initiates the intrinsic coagulation pathway. Prekallikrein deficiency results in prolonged Partial Throm...Prekallikrein deficiency is a disorder that often remains undiagnosed. Prekallikrein activates factor XII, which initiates the intrinsic coagulation pathway. Prekallikrein deficiency results in prolonged Partial Thromboplastin Time and Activated Clotting Time in absence of anticoagulants or active bleeding. This case report describes the anesthesia management of a patient with Prekallikrein deficiency who underwent cardiac surgery with Cardiopulmonary Bypass for correction of a congenital cardiac malformation. We highlight the importance of understanding the different tests available for the diagnosis of coagulation factors deficiency during administration of heparin in the setting of cardiovascular procedures under general anesthesia.展开更多
In this paper we dicuss the convergence of the modified Broyden algorithms. We prove that the algorithms are globally convergent for the continuous differentiable function and the rate of convergence of the algorithms...In this paper we dicuss the convergence of the modified Broyden algorithms. We prove that the algorithms are globally convergent for the continuous differentiable function and the rate of convergence of the algorithms is one-step superlinear and n-step second-order for the uniformly convex objective function. From the discussion of this paper, we may get some convergence properties of the Broyden algorithms.展开更多
AIM To evaluate the efficacy of doubling time(DT) of gastrointestinal submucosal tumors(GIST).METHODS From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GI...AIM To evaluate the efficacy of doubling time(DT) of gastrointestinal submucosal tumors(GIST).METHODS From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GISTs on surgical resection or endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) in Kitasato University East Hospital or Kitasato University Hospital. We studied 53 of these patients(34 with resected tumors and 19 with unresected tumors) whose tumors could be measured on EUS on at least two successive occasions. The histopathological diagnosis was GIST in 34 patients, leiomyoma in 5, schwannoma in 3, ectopic pancreas in 1, hamartoma in 1, cyst in 1, Brunner's adenoma in 1, and spindle-cell tumor in 7. We retrospectively calculated the DT of GISTs on the basis of the time course of EUS findings to estimate the growth rate of such tumors.RESULTS The DT was 17.2 mo for GIST, as compared with 231.2 mo for leiomyoma, 104.7 mo for schwannoma, 274.9mo for ectopic pancreas, 61.2 mo for hamartoma, 49.0 mo for cyst, and 134.7 mo for Brunner's adenoma. The GISTs were divided into risk classes on the basis of tumor diameters and mitotic figures(Fletcher's classification). The classification was extremely low risk or low risk in 28 patients, intermediate risk in 3, and high risk in 3. DT of GIST according to risk was 24.0 mo for extremely low-risk plus low-risk GIST, 17.1 mo for intermediate-risk GIST, and 3.9 mo for high-risk GIST. DT of GIST was significantly shorter than that of leiomyoma plus schwannoma(P < 0.05), and DT of high-risk GIST was significantly shorter than that of extremely low-risk plus low-risk GIST(P < 0.05).CONCLUSION For GIST, a higher risk grade was associated with a significantly shorter DT. Small SMTs should initially be followed up within 6 mo after detection.展开更多
In this paper, a new approach to the optimal retrieval of the ocean color based on the variational method is developed by setting up a rational target functional combining with the Broydor Fletcher, Goldfarb, Shanno ...In this paper, a new approach to the optimal retrieval of the ocean color based on the variational method is developed by setting up a rational target functional combining with the Broydor Fletcher, Goldfarb, Shanno （BFGS） optimal algorithm. The numerical tests and the exemplary retrievals are carried out and compared with the statistical retrievals and the optimal retrievals based on the genetic algorithm. The results show that this approach enjoys a higher accuracy as compared to the statistical method and a higher efficiency as compared to the genetic algorithm. The optimal retrieval method presented in this paper provides a new idea for the ocean color inversion and could also be used as a reference for the direct assimilation of the satellite data into the ecological models.展开更多
This paper proposes a two-piece update of projected reduced Hessian algorithmwith nonmonotonic trust region strategy for solving nonlinear equality constrained optimizationproblems. In order to deal with large problem...This paper proposes a two-piece update of projected reduced Hessian algorithmwith nonmonotonic trust region strategy for solving nonlinear equality constrained optimizationproblems. In order to deal with large problems, a two-piece update of two-side projected reducedHessian is used to replace full Hessian matrix. By adopting the Fletcher's penalty function as themerit function, a nonmonotonic trust region strategy is suggested which does not require the meritfunction to reduce its value in every iteration. The two-piece update of projected reduced Hessianalgorithm which switches to nonmonotonic trust region technique possesses global convergence whilemaintaining a two-step Q-superlinear local convergence rate under some reasonable conditions.Furthermore, one step Q-superlinear local convergence rate can be obtained if at least one of theupdate formulas is updated at each iteration by an alternative update rule. The numerical experimentresults are reported to show the effectiveness of the proposed algorithm.展开更多
Calanoida copepod, Drepanopus bispinosus occurred in both saline lakes, Burton ( S=40) and Fletcher ( S = 56) in Vestfold Hills, Antarctica. Evident differences between two populations in biology and physiology were o...Calanoida copepod, Drepanopus bispinosus occurred in both saline lakes, Burton ( S=40) and Fletcher ( S = 56) in Vestfold Hills, Antarctica. Evident differences between two populations in biology and physiology were observed in September and December, 1984. The population in the Burton lake was denser with stronger body and more tolerant to temperature and salinity than that in the Fletcher Lake, reflecting their possible differences of genetic or nongenetic adaptation. The population in the Burton lake has been adaptated to the lake environment, and the population in the Flethcer Lake is in the acclimatization course in the lake habitat.展开更多
文摘AIM:To report our experience of gastrointestinal stromal tumors (GISTs) during the last 29 years. METHODS:Thirty two cases of GIST referred to our Institution from the 1st January 1981 to the 10th June 2010 were reviewed. Metastases,recurrence and survival data were collected in relation to age,history,clinical presentation,location,size,resection margins and cellular features. RESULTS:Mean age was 63.7 years (range,40-90) and incidence was slightly higher in males (56%). R0 resection was performed in 90.7% of cases,R1 in 6.2% (2 cases) and R2 in 3.1% (one case). Using Fletcher's classification 8/32 (25%) had high risk,9/32 (28%) intermediate and 15/32 (47%) low risk tumors. Follow-up varied from 1 mo to 29 years,with a median of 8 years; overall survival was 75% (24/32),disease-free survival was 72% and tumor-related mortality was 9.3%. Three patients with high risk GIST were treated with imatinib mesylate:one developed a recurrence after 36 mo,and 2 are free from disease at 41 mo. CONCLUSION:Surgical treatment remains the gold standard therapy for resectable GISTs. Pathological and biological features of the neoplasm represent the most important factors predicting the prognosis.
文摘Prekallikrein deficiency is a disorder that often remains undiagnosed. Prekallikrein activates factor XII, which initiates the intrinsic coagulation pathway. Prekallikrein deficiency results in prolonged Partial Thromboplastin Time and Activated Clotting Time in absence of anticoagulants or active bleeding. This case report describes the anesthesia management of a patient with Prekallikrein deficiency who underwent cardiac surgery with Cardiopulmonary Bypass for correction of a congenital cardiac malformation. We highlight the importance of understanding the different tests available for the diagnosis of coagulation factors deficiency during administration of heparin in the setting of cardiovascular procedures under general anesthesia.
文摘In this paper we dicuss the convergence of the modified Broyden algorithms. We prove that the algorithms are globally convergent for the continuous differentiable function and the rate of convergence of the algorithms is one-step superlinear and n-step second-order for the uniformly convex objective function. From the discussion of this paper, we may get some convergence properties of the Broyden algorithms.
文摘AIM To evaluate the efficacy of doubling time(DT) of gastrointestinal submucosal tumors(GIST).METHODS From April 1987 through November 2012, a total of 323 patients were given a final histopathological diagnosis of GISTs on surgical resection or endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) in Kitasato University East Hospital or Kitasato University Hospital. We studied 53 of these patients(34 with resected tumors and 19 with unresected tumors) whose tumors could be measured on EUS on at least two successive occasions. The histopathological diagnosis was GIST in 34 patients, leiomyoma in 5, schwannoma in 3, ectopic pancreas in 1, hamartoma in 1, cyst in 1, Brunner's adenoma in 1, and spindle-cell tumor in 7. We retrospectively calculated the DT of GISTs on the basis of the time course of EUS findings to estimate the growth rate of such tumors.RESULTS The DT was 17.2 mo for GIST, as compared with 231.2 mo for leiomyoma, 104.7 mo for schwannoma, 274.9mo for ectopic pancreas, 61.2 mo for hamartoma, 49.0 mo for cyst, and 134.7 mo for Brunner's adenoma. The GISTs were divided into risk classes on the basis of tumor diameters and mitotic figures(Fletcher's classification). The classification was extremely low risk or low risk in 28 patients, intermediate risk in 3, and high risk in 3. DT of GIST according to risk was 24.0 mo for extremely low-risk plus low-risk GIST, 17.1 mo for intermediate-risk GIST, and 3.9 mo for high-risk GIST. DT of GIST was significantly shorter than that of leiomyoma plus schwannoma(P < 0.05), and DT of high-risk GIST was significantly shorter than that of extremely low-risk plus low-risk GIST(P < 0.05).CONCLUSION For GIST, a higher risk grade was associated with a significantly shorter DT. Small SMTs should initially be followed up within 6 mo after detection.
基金Project supported by the National Natural Science Foundation of China(Grant No. 41105012)Startup Fund Scientific Research from the Institute of Meteorology, PLA University of Science and Technology(Grant No. 2009QX08)
文摘In this paper, a new approach to the optimal retrieval of the ocean color based on the variational method is developed by setting up a rational target functional combining with the Broydor Fletcher, Goldfarb, Shanno （BFGS） optimal algorithm. The numerical tests and the exemplary retrievals are carried out and compared with the statistical retrievals and the optimal retrievals based on the genetic algorithm. The results show that this approach enjoys a higher accuracy as compared to the statistical method and a higher efficiency as compared to the genetic algorithm. The optimal retrieval method presented in this paper provides a new idea for the ocean color inversion and could also be used as a reference for the direct assimilation of the satellite data into the ecological models.
基金the National Natural Science Foundation of China(31860095)Guizhou Science and Technology Foundation of China(QKHJC[2018]1193)Zhuhai Premier-Discipline Enhancement Scheme of Pharmacology,Zhuhai Campus of Zunyi Medical University
基金The author gratefully acknowledges the partial supports of the National Science Foundation of China Grant (10071050)Science Foundation of Shanghai Technical Sciences Committee Grant (02ZA14070) Science Foundation of Shanghai Education Committee Grant
文摘This paper proposes a two-piece update of projected reduced Hessian algorithmwith nonmonotonic trust region strategy for solving nonlinear equality constrained optimizationproblems. In order to deal with large problems, a two-piece update of two-side projected reducedHessian is used to replace full Hessian matrix. By adopting the Fletcher's penalty function as themerit function, a nonmonotonic trust region strategy is suggested which does not require the meritfunction to reduce its value in every iteration. The two-piece update of projected reduced Hessianalgorithm which switches to nonmonotonic trust region technique possesses global convergence whilemaintaining a two-step Q-superlinear local convergence rate under some reasonable conditions.Furthermore, one step Q-superlinear local convergence rate can be obtained if at least one of theupdate formulas is updated at each iteration by an alternative update rule. The numerical experimentresults are reported to show the effectiveness of the proposed algorithm.
文摘Calanoida copepod, Drepanopus bispinosus occurred in both saline lakes, Burton ( S=40) and Fletcher ( S = 56) in Vestfold Hills, Antarctica. Evident differences between two populations in biology and physiology were observed in September and December, 1984. The population in the Burton lake was denser with stronger body and more tolerant to temperature and salinity than that in the Fletcher Lake, reflecting their possible differences of genetic or nongenetic adaptation. The population in the Burton lake has been adaptated to the lake environment, and the population in the Flethcer Lake is in the acclimatization course in the lake habitat.
