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A method of characterizing land-cover swap changes in the arid zone of China
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作者 Yecheng YUAN Baolin LI +3 位作者 Xizhang GAO Haijiang LIU Lili XU Chenghu ZHOU 《Frontiers of Earth Science》 SCIE CAS CSCD 2016年第1期74-86,共13页
Net area change analysis can dramatically underestimate total change of land cover, even sometimes seriously misinterpret ecological processes of the ecosystem, especially in arid or semiarid zones. In this paper, a s... Net area change analysis can dramatically underestimate total change of land cover, even sometimes seriously misinterpret ecological processes of the ecosystem, especially in arid or semiarid zones. In this paper, a suite of indices are presented to characterize land-cover swaps that may seriously damage the ecosystem in arid or semiarid zones, based on swap-change areas extracted from remotely sensed images. First, swap percentage of total area and swap intensity of total changes were used to determine the status of land-cover swap change in an area. Then, dominated swap category and individual swap- change intensity for a land-cover category were used to determine flagged land-cover swap-change categories. Finally, swap-change mode and Pielou's index were used to determine the land-cover swap-change processes of dominant categories. A case study is conducted using this approach, based on two land-cover maps in the 1980s and 2000 in Naiman Qi, Tongliao City, Inner Mongolia, China. This study shows that the approach can clearly quantify the severity and flagged classes of land-cover swap-change and reveal their relationship with ecological processes of the ecosystem. These results indicate that the approach can give deep insights into swap change, which can be very valuable to land-cover policy making and management. 展开更多
关键词 land cover swap swap-change status flagged swap-change categories swap-change process arid/semiarid zone
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Upper bounds of Schubert polynomials
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作者 Neil Jiuyu Fan Peter Long Guo 《Science China Mathematics》 SCIE CSCD 2022年第6期1319-1330,共12页
Let w be a permutation of{1,2,...,n},and let D(w)be the Rothe diagram of w.The Schubert polynomial■w_(x)can be realized as the dual character of the flagged Weyl module associated with D(w).This implies the following... Let w be a permutation of{1,2,...,n},and let D(w)be the Rothe diagram of w.The Schubert polynomial■w_(x)can be realized as the dual character of the flagged Weyl module associated with D(w).This implies the following coefficient-wise inequality:Min_(x)≤■_(w)(x)≤Max_(w)xwhere both Min_(w)(x)and Max_(w)(x)are polynomials determined by D(w).Fink et al.(2018)found that■w_(x)equals the lower bound Min_(w)(x)if and only if w avoids twelve permutation patterns.In this paper,we show that■w_(x)reaches the upper bound Max_(w)(x)if and only if w avoids two permutation patterns 1432 and 1423.Similarly,for any given compositionα∈Z^(n)≥0,one can define a lower bound Min_(α)(x)and an upper bound Max_(α)(x)for the key polynomialκ_(α)(x).Hodges and Yong(2020)established thatκ_(α)(x)equals Min_(α)(x)if and only ifαavoids five composition patterns.We show thatκ_(α)(x)equals Max_(α)(x)if and only ifαavoids a single composition pattern(0,2).As an application,we obtain that whenαavoids(0,2),the key polynomialκ_(α)(x)is Lorentzian,partially verifying a conjecture of Huh et al.(2019). 展开更多
关键词 Schubert polynomial key polynomial flagged Weyl module upper bound Lorentzian polynomial
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DIRECT PROOF OF THE DETERMINANT EXPRESSION FOR FLAGGED SKEW TABLEAUX
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作者 初文昌 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 1992年第4期318-322,共5页
Flagged skew tableaux are generalizationa of Young tableaux in which each row (column)has an upper and lower bound on the entries. It has been shown that they are enumerated byflagged skew Schur functions. By introdu... Flagged skew tableaux are generalizationa of Young tableaux in which each row (column)has an upper and lower bound on the entries. It has been shown that they are enumerated byflagged skew Schur functions. By introducing the dominance technique, we preeent an alternateproof for this conclusion directly. 展开更多
关键词 DIRECT PROOF OF THE DETERMINANT EXPRESSION FOR flagged SKEW TABLEAUX
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标志前缀加法器的结构优化设计 被引量:2
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作者 许团辉 王玉艳 章建雄 《计算机工程》 CAS CSCD 北大核心 2010年第13期286-287,290,共3页
标志前缀加法器运算速度快但存在面积大的缺点。为满足实际应用中对浮点乘加单元面积的要求,对其进行结构优化得到基于Kogge-stone树结构的51位标志前缀加法器,采用模块级联减少运算单元个数,达到减小浮点乘加单元面积、降低功耗的目的... 标志前缀加法器运算速度快但存在面积大的缺点。为满足实际应用中对浮点乘加单元面积的要求,对其进行结构优化得到基于Kogge-stone树结构的51位标志前缀加法器,采用模块级联减少运算单元个数,达到减小浮点乘加单元面积、降低功耗的目的。在TMSC 0.18μm工艺下,该51位加法器的面积、总功耗、关键路径时延分别减少了10%,10.5%,6.4%。 展开更多
关键词 标志前缀加法器 浮点运算 结构优化
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WORLD
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《Beijing Review》 2019年第24期8-9,共2页
THE PHILIPPINES The MV Bavaria,a Liberian-flagged container ship,at the Subic Bay Freeport on May 30.It has been commissioned to take truckloads of garbage that Canada transported to the Philippines from 2013 back to ... THE PHILIPPINES The MV Bavaria,a Liberian-flagged container ship,at the Subic Bay Freeport on May 30.It has been commissioned to take truckloads of garbage that Canada transported to the Philippines from 2013 back to Canada. 展开更多
关键词 MV BAVARIA Liberian-flagged CONTAINER ship Subic BAY FREEPORT
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Three Australian leg-flagged Great Knots(Calidris tenuirostris) found on the islet coast of Jinmen(Quimoy) in Fujian,China
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作者 Chung-Wei YEN 《Zoological Research》 CAS CSCD 2015年第2期115-116,共2页
DEAR EDITOR On April 7, 2013, approximately 50 Great Knots (Calidris tenuirostris), Red Knots (C. canutus) and Bar-tailed Godwits (Limosa lapponica) were seen on the coast of Jinmen (Quimoy) (N24°26′; E... DEAR EDITOR On April 7, 2013, approximately 50 Great Knots (Calidris tenuirostris), Red Knots (C. canutus) and Bar-tailed Godwits (Limosa lapponica) were seen on the coast of Jinmen (Quimoy) (N24°26′; E118°18′) in Fujian, China. Among these birds, three Great Knots were banded with Australian yellow leg-flags (ENE, LCC and USP in Figures 1, 2 and 3, respectively), which are new to Jinmen. 展开更多
关键词 Bay in Fujian China Calidris tenuirostris Quimoy Three Australian leg-flagged Great Knots found on the islet coast of Jinmen
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Three Australian leg-flagged Roseate Terns found at Caiyu Archipelago of SE Fujian, China
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作者 林植 何芬奇 《Chinese Birds》 2012年第1期67-70,共4页
In undertaking regular surveys on those waterbirds appearing on Fujian coast and on offshore islands,people of Xiamen Bird-watching Society had observed,for five times during 2007-2009,three marked individuals of the ... In undertaking regular surveys on those waterbirds appearing on Fujian coast and on offshore islands,people of Xiamen Bird-watching Society had observed,for five times during 2007-2009,three marked individuals of the Roseate Tern (Sterna dougallii) on Caiyu Archipelago of south Fujian offshore; it is now quite certain that the leg-flags were marked on birds by people of the Australasian Wader Studies Group (AWSG) and at least one of those leg-flagged terns is already over six or seven years old by the time of re-sighting; this record might be useful and helpful for further estimating the life circle as well as the length of generation of those gulls and terns appearing and breeding along the SE Chinese coast,such as the Black-tailed Gull (Larus crassirostris),the Great Crested Tern (Sterna bergii),the Chinese Crested Tern (S.bernsteini),etc. 展开更多
关键词 Roseate Tern Sterna dougallii found banded and leg-flagged Caiyu Archipelago southeast Fujian coast of SE China
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美国海岸警备队实施港口国管理新方案之我见
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作者 叶光煌 《集美航海学院学报》 1997年第3期15-20,共6页
近年来,美国海岸警备队为了排除低标准船进出美国港口,加强对外国籍船的监督检查,出台并实施了港口国管理新方案.本文就新方案产生的背景、新方案的特点、实施新方案带来的影响以及外国籍船如何采取措施作了全面的探讨.
关键词 美国海岸警备队 港口国管理 新方案 外国籍船
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Studies on the Characteristics of Chlorophyll Fluorescence of Winter Wheat Flag Leaves at Different Developing Stages 被引量:28
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作者 卢庆陶 李卫华 +4 位作者 蒋高明 戈巧英 郝乃斌 孙家柱 郭仁峻 《Acta Botanica Sinica》 CSCD 2001年第8期801-804,共4页
The parameters of fluorescence induction kinetics and the maximal light-saturated net CO2 assimilation rate (P-sat) of the flag leaves of four cultivars of winter wheat (Triticum aestivum L.) were compared at three di... The parameters of fluorescence induction kinetics and the maximal light-saturated net CO2 assimilation rate (P-sat) of the flag leaves of four cultivars of winter wheat (Triticum aestivum L.) were compared at three different developing stages for the first time. From the blooming stage to the milky stage, the quantum efficiency of PS II photochemistry (F-v/F-m) declined slightly only at the milk stage. The photochemical quenching co-efficient (qP), actual quantum yield of photosystem II (PS II)electron transport (Phi (PSII)) and P-sat decreased substantially (> 15%), while the non-photochemical quenching co-efficient (qN) increased significantly (> 100%). There existed a linear correlation between the Phi (PSII) and the P-sat (r = 0.918). The results indicate that with the senescence of the flag leaves of winter wheat the photosynthetic efficiency including that of the energy transport and the CO2 assimilation significantly decreased. 展开更多
关键词 winter wheat flag leave fluorescence kinetics PHOTOSYNTHESIS
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菩萨引路:唐宋时期丧葬仪式中的引魂幡 被引量:26
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作者 王铭 《敦煌研究》 CSSCI 北大核心 2014年第1期37-45,共9页
晚唐五代敦煌出现引路菩萨接引亡者像,画面上引路菩萨手持引魂幡,具有接引亡魂往生的信仰意义。引路菩萨接引亡者像具有鲜明的宗教意涵,引魂幡无形中包含了神秘的信仰意味。这种带有明显佛教特点的引魂幡,是儒家旌旗制度在中古佛教影响... 晚唐五代敦煌出现引路菩萨接引亡者像,画面上引路菩萨手持引魂幡,具有接引亡魂往生的信仰意义。引路菩萨接引亡者像具有鲜明的宗教意涵,引魂幡无形中包含了神秘的信仰意味。这种带有明显佛教特点的引魂幡,是儒家旌旗制度在中古佛教影响下的一种变体。在唐宋时期,佛幡与儒家传统旌旗在丧葬仪式中的融合和创造,形成了引魂幡。 展开更多
关键词 旗帜 幢幡 引魂幡 引路菩萨 往生信仰
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JPEG图像数据格式简明分析 被引量:14
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作者 邢赛鹏 平西建 詹杰勇 《微计算机信息》 北大核心 2005年第12X期166-168,共3页
本文针对最常见的JPEG图像格式的压缩数据进行分析,描述了每一字节的数据所表示的含义,同时也介绍了JPEG图像格式中的大部分典型且必要的标记、参数等元素,这些都是对JPEG图像作进一步的研究的基础知识。
关键词 JPEG 静止图像 图像格式 标记
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复合水泥基-水玻璃双液注浆材料胶凝性能及抗压强度试验研究 被引量:14
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作者 巫茂寅 王起才 +3 位作者 张戎令 田鹤翔 张凯 王小龙 《硅酸盐通报》 CAS CSCD 北大核心 2016年第9期2741-2746,共6页
传统的水泥水玻璃双液注浆材料的优点在于凝胶时间短、早期的抗压强度大,所以在加固软弱地层或堵漏中被广泛的使用。本文在传统材料的基础上,加入了粉煤灰、矿粉等工业废渣,提出一种复合水泥基-水玻璃双液注浆材料,并对新型材料的胶凝... 传统的水泥水玻璃双液注浆材料的优点在于凝胶时间短、早期的抗压强度大,所以在加固软弱地层或堵漏中被广泛的使用。本文在传统材料的基础上,加入了粉煤灰、矿粉等工业废渣,提出一种复合水泥基-水玻璃双液注浆材料,并对新型材料的胶凝性能和28 d抗压强度进行研究,并通过改变水玻璃体积掺量、波美度和矿物掺合料比例来研究浆液凝胶时间及28 d抗压强度的变化规律;当水玻璃体积掺量为25%时,浆液硬化结石体强度最大,使用更大波美度的水玻璃或者配制合适比例的水泥、粉煤灰和矿粉的复合水泥基A液都可以提升双液注浆材料的抗压强度。 展开更多
关键词 双液注浆材料 水玻璃 粉煤灰 矿粉 胶凝性能
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Mapping Quantitative Trait Loci for Post-Anthesis Dry Matter Accumulation in Wheat 被引量:9
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作者 Jun-Ying Su Yi-Ping Tong +4 位作者 Quan-You Liu Bin Li Rui-Lian Jing Ji-Yun Li Zhen-Sheng Li 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2006年第8期938-944,共7页
Post-anthesis photoassimilation is very important for wheat (Triticum aestivum L.) grain filling. The aim of the present study was to map quantitative trait loci (QTL) for post-anthesis dry matter accumulation (... Post-anthesis photoassimilation is very important for wheat (Triticum aestivum L.) grain filling. The aim of the present study was to map quantitative trait loci (QTL) for post-anthesis dry matter accumulation (DMA). A set of 120 doubled haploid (DH) lines, derived from winter wheat varieties Hanxuan 10 and Lumai 14, was grown under field conditions in two consecutive growing seasons during 2002-2004 in Beijing. Post-anthesis DMA per culm and related traits, including flag leaf greenness (FLG) and flag leaf weight (FLW; dry weight per flag leaf) at flowering, and grain weight per ear (GWE) were investigated. All traits segregated continuously in the DH population in both trials. The DMA was significantly and positively correlated with GWE, with the correlation coefficients being 0.79 and 0.66 in the 2002-2003 and 2003-2004 growing seasons (both P〈0.01), suggesting the importance of DMA in grain filling. Further correlation analysis showed that FLW was more closely correlated with DMA and GWE than FLG in both growing seasons, indicating that FLW was more important than FLG in influencing DMA and GWE. In total, 30 QTLs for these four traits were mapped and distributed on 10 chromosomes. Phenotypic variations explained by an individual QTL were in the range 5.8%-21.3%, 5.9%-17.2%, 5.1%-18.1%, and 5.6%-16.2% for FLG, FLW, DMA, and GWE, respectively. Eight QTLs for DMA were detected, of which four (on chromosome arms 2AS, 4BL, 5AS, and 7AS) were linked with QTLs for GWE; two (on chromosome arms 5BL and 7BL) coincided with QTLs for FLW. These results may provide useful information for developing marker-assisted selection for the improvement of DMA. 展开更多
关键词 flag leaf greenness flag leaf weight grain filling post-anthesis dry matter accumulation quantitative trait loci(QTL) Triticum aestivum.
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Comparison study on water use efficiency of wheat flag leaf 被引量:11
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作者 Zhang, ZB Shan, L 《Chinese Science Bulletin》 SCIE EI CAS 1998年第14期1205-1211,共7页
wild species and cultivars were planted under irrigated and dryland field condition. LCA\|3 model photosynthesis apparatus was employed to measure flag leaf WUE. The results show that WUE of diploid and tetraploid inc... wild species and cultivars were planted under irrigated and dryland field condition. LCA\|3 model photosynthesis apparatus was employed to measure flag leaf WUE. The results show that WUE of diploid and tetraploid increases as the wild species became cultivated species. WUE of flag leaf increases as the chromosome ploid increases (2\%n\%→4\%n\%→6\%n\%) in the wheat evolution. Among modern cultivars, WUE of most irrigated varieties is higher than that of dryland varieties. 展开更多
关键词 WHEAT flag LEAF water USE efficiency.
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Sorcin高表达与胃癌细胞株SGC7901多药耐药的关系 被引量:9
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作者 何青春 张桂英 曹伟军 《癌症》 SCIE CAS CSCD 北大核心 2008年第4期337-342,共6页
背景与目的:长春新碱耐药胃癌细胞SGC7901/VCR是具有P-糖蛋白(P-gp)高表达的典型多药耐药细胞,但P-gp抑制剂维拉帕米(VRP)不能完全逆转其耐药,说明还存在其它耐药机制。我们运用差异蛋白质组学技术研究发现,可溶性耐药相关钙结合蛋白(So... 背景与目的:长春新碱耐药胃癌细胞SGC7901/VCR是具有P-糖蛋白(P-gp)高表达的典型多药耐药细胞,但P-gp抑制剂维拉帕米(VRP)不能完全逆转其耐药,说明还存在其它耐药机制。我们运用差异蛋白质组学技术研究发现,可溶性耐药相关钙结合蛋白(Sorcin)在SGC7901/VCR中表达较SGC7901细胞明显上调。为进一步阐明Sorcin与胃癌细胞耐药的关系,本研究构建了FLAG-Sorcin融合表达载体,探讨Sorcin在胃癌多药耐药中的作用。方法:采用逆转录聚合酶链反应法(reverse transcription-polymerase chain reaction,RT-PCR)扩增Sorcin cDNA片段编码区序列全长,DNA重组技术构建FLAG-Sorcin融合表达载体,经脂质体介导稳定转染SGC7901细胞,RT-PCR及Western blot分别检测转染细胞Sorcin mRNA表达的变化;噻唑蓝(MTT)法测定转染细胞及对照细胞对化疗药物的敏感性。用Sorcin反义核苷酸转染SGC7901-F-SOR细胞,RT-PCR检测Sorcin表达水平的变化,MTT法测定转染后细胞对VCR敏感性的变化。结果:RT-PCR法扩增出616bp全长Sorcin cDNA片段,成功构建了FLAG-Sorcin融合表达载体;RT-PCR及Western blot证实,Sorcin在SGC7901转染细胞中高表达;Sorcin高表达的SGC7901细胞对长春新碱(VCR)、阿霉素(ADM)、紫杉醇(Taxol)、氟尿嘧啶(5-FU)分别产生了8.87倍、6.13倍、6.67倍和2.80倍耐药。Sorcin反义核苷酸转染SGC7901-F-SOR细胞后,RT-PCR验证Sorcin表达被抑制,MTT结果显示细胞对VCR敏感性增加。结论:Sorcin高表达可致SGC7901细胞产生低倍数的多药耐药,说明Sorcin与SGC7901细胞多药耐药密切相关,有望成为逆转胃癌多药耐药的靶点。 展开更多
关键词 SORCIN flag 多药耐药 胃癌细胞株
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Contribution of the ear and the flag leaf to grainfilling in durum wheat inferred from the carbon isotope signature: Genotypic and growing conditions effects 被引量:10
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作者 Rut Sanchez-Bragado Abdelhalim Elazab +4 位作者 Bangwei Zhou Maria Dolors Serret Jordi Bort Maria Teresa Nieto-Taladriz José Luis Araus 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2014年第5期444-454,共11页
The ear, together with the flag leaf, is believed to play a major role as a source of assimilates during grain filling in C3cereals. However, the intrusive nature of most of the available methodologies prevents reachi... The ear, together with the flag leaf, is believed to play a major role as a source of assimilates during grain filling in C3cereals. However, the intrusive nature of most of the available methodologies prevents reaching conclusive results in this regard. This study compares the carbon isotope composition(d13C) in its natural abundance in the water‐soluble fractions of the flag leaf blade and the ear with the d13C of mature kernels to assess the relative contribution of both organs to grain filling in durum wheat(Triticum turgidum L. var.durum). The relative contribution of the ear was higher in landraces compared to modern cultivars, as well as in response to nitrogen fertilization and water stress. Such genotypic and environmentally driven differences were associated with changes in harvest index(HI), with the relative contribution of the ear being negatively associated with HI. In the case of the genotypic differences, the lower relative contribution of the ear in modern cultivars compared with landraces is probably associated with the appearance in the former of a certain amount of source limitation driven by a higher HI. In fact, the relative contribution of the ear was far more responsive to changes in HI in modern cultivars compared with landraces. 展开更多
关键词 Carbon isotope discrimination EAR flag leaf grain filling harvest index PHOTOSYNTHESIS
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无损压缩算法LZW前缀编码优化及应用 被引量:11
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作者 鄢海舟 胥布工 +1 位作者 石东江 郑伟德 《计算机工程》 CAS CSCD 北大核心 2017年第3期299-303,共5页
利用LZW算法进行数据压缩,当字典长度为l时,前缀在区间[0,l-1]中,因而只能通过「Ibl」bit对前缀进行编码,使区间[l,2^(「Ibl」)-1]内的数据不能被充分利用,造成冗余现象。针对该问题,提出一种前缀映射编码的改进压缩算法。对满足条件的... 利用LZW算法进行数据压缩,当字典长度为l时,前缀在区间[0,l-1]中,因而只能通过「Ibl」bit对前缀进行编码,使区间[l,2^(「Ibl」)-1]内的数据不能被充分利用,造成冗余现象。针对该问题,提出一种前缀映射编码的改进压缩算法。对满足条件的前缀不直接编码输出,而是将其映射到区间[l,2^(「Ibl」)-1],此时编码位数并未减少但却隐含一个标志位信息,标志下一个前缀编码用更少的比特位来编码。与原LZW算法相比,改进算法不增加计算量和存储空间,并且通用性好。英文文本数据压缩仿真和残差数据压缩应用结果均验证了该算法的有效性。 展开更多
关键词 LZW算法 前缀映射 编码 无损压缩 标志位 去冗余
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水稻孕穗期叶绿素含量的QTL定位 被引量:11
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作者 范淑秀 王嘉宇 +1 位作者 毛艇 徐正进 《华北农学报》 CSCD 北大核心 2010年第4期69-72,共4页
利用由籼稻品种七山占与粳稻品种秋光杂交构建的一个包含162个株系(F10)的重组自交系群体,及其相应的包含122个SSR标记的遗传图谱,采用区间定位方法,对控制水稻孕穗期剑叶叶绿素含量的QTL进行定位分析。共检测到22个与孕穗期叶绿素含量... 利用由籼稻品种七山占与粳稻品种秋光杂交构建的一个包含162个株系(F10)的重组自交系群体,及其相应的包含122个SSR标记的遗传图谱,采用区间定位方法,对控制水稻孕穗期剑叶叶绿素含量的QTL进行定位分析。共检测到22个与孕穗期叶绿素含量有关的QTL,分别位于第3、7、10和12染色体上,包括对6个叶绿素a含量QTL、5个叶绿素b含量QTL、5个类胡萝卜素含量QTL和6个总叶绿素含量QTL,单个QTL对性状表型贡献率为7.4%~14.6%。 展开更多
关键词 水稻 重组自交系 剑叶 叶绿素含量
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基于FPGA的异步FIFO缓存设计 被引量:9
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作者 肖静娴 戴亚文 《电子测量技术》 2009年第11期92-94,共3页
介绍了异步FIFO的类型以及工作原理,研究了使用用FPGA芯片内部的双口RAM来实现异步FIFO设计方案,重点阐述了如何判断空/满标志信号以及消除亚稳态的设计思路。针对多位跨时钟域的数据传输,可能出现亚稳态导致数据出现不可知的错误,讨论... 介绍了异步FIFO的类型以及工作原理,研究了使用用FPGA芯片内部的双口RAM来实现异步FIFO设计方案,重点阐述了如何判断空/满标志信号以及消除亚稳态的设计思路。针对多位跨时钟域的数据传输,可能出现亚稳态导致数据出现不可知的错误,讨论了通过格雷码对读写地址进行编码以用来减少亚稳态出现的概率,并给出了具体的程序流程图,进行了仿真验证。这种方法设计的异步FIFO具有高速,高可靠性,移植性强的特点。 展开更多
关键词 异步FIFO 亚稳态 格雷码 空/满标志
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FLAG和MEA方案治疗难治复发性急性髓系白血病的Meta分析 被引量:9
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作者 刘祥祥 张涛 +6 位作者 王健红 张娜 郝彩霞 鲁英娟 郭华燕 段晓晖 梁蓉 《现代肿瘤医学》 CAS 2019年第4期636-640,共5页
目的:系统评价氟达拉滨+阿糖胞苷+重组人粒细胞集落刺激因子(FLAG)和米托蒽醌+依托泊苷+阿糖胞苷(MEA)方案治疗难治复发性急性髓系白血病(RRAML)的疗效及不良反应。方法:计算机检索Pub Med、Cochrane Library、Web of Science、VIP、Wan... 目的:系统评价氟达拉滨+阿糖胞苷+重组人粒细胞集落刺激因子(FLAG)和米托蒽醌+依托泊苷+阿糖胞苷(MEA)方案治疗难治复发性急性髓系白血病(RRAML)的疗效及不良反应。方法:计算机检索Pub Med、Cochrane Library、Web of Science、VIP、Wan Fang Data、CNKI、CBM等数据库发表的关于FLAG和MEA方案治疗RRAML的随机对照试验(RCT)。由两位研究者独立进行文献筛选、资料提取和质量评价后,采用Rev Man 5. 0软件进行Meta分析。结果:共纳入6个研究,299例患者。Meta分析结果显示:FLAG方案和MEA方案治疗RRAML时,两者的CR[RR=1. 49,95%CI(0. 92,2. 43),P=0. 11]及PR[RR=1. 38,95%CI(0. 82,2. 32),P=0. 23]无明显差异,但FLAG方案治疗组的总有效率高于MEA方案治疗组,两组的差异有统计学意义[RR=1. 98,95%CI(1. 21,3. 24),P=0. 006],其真菌感染率亦高于MEA组,两组的差异有统计学意义[RR=2. 17,95%CI(1. 09,4. 31),P=0. 03]。结论:FLAG方案治疗RRAML的总有效率高于MEA方案,但其真菌感染率亦高。受纳入研究的数量及质量限制,本系统评价结论仍需进一步开展更多大样本、严格设计的随机对照试验加以验证。 展开更多
关键词 flag MEA 难治复发性急性髓系白血病 META分析 系统评价 随机对照试验
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