Eelectrospun polyhydroxylbutyrate fibrous mats containing ciprofloxacin are prepared by electrospinning,and the surface morphology of the fibrous mats is investigated by scanning electron microscope.The efficiency of ...Eelectrospun polyhydroxylbutyrate fibrous mats containing ciprofloxacin are prepared by electrospinning,and the surface morphology of the fibrous mats is investigated by scanning electron microscope.The efficiency of encapsulation,drug release behavior in vitro,and anti-bacteria activity of the fibrous mats are studied.The results show that the entrapment efficiency of electrospun scaffolds nearly reached 100%;the drug release duration is about 25 days,and the drug release of about 57% can be observed in initial 24h.The conclusions are that the electrospun polyhydroxylbutyrate fibrous mats containing ciprofloxacin have good function of controlled release,and it can inhibit the growth of S.aureus very well.展开更多
文摘Eelectrospun polyhydroxylbutyrate fibrous mats containing ciprofloxacin are prepared by electrospinning,and the surface morphology of the fibrous mats is investigated by scanning electron microscope.The efficiency of encapsulation,drug release behavior in vitro,and anti-bacteria activity of the fibrous mats are studied.The results show that the entrapment efficiency of electrospun scaffolds nearly reached 100%;the drug release duration is about 25 days,and the drug release of about 57% can be observed in initial 24h.The conclusions are that the electrospun polyhydroxylbutyrate fibrous mats containing ciprofloxacin have good function of controlled release,and it can inhibit the growth of S.aureus very well.
