Objective：To explore the effect of Tanreqing Injection（痰热清注射液,TRQI） on the treatment of acute exacerbation of chronic obstructive pulmonary disease（AECOPD） with Chinese medicine syndrome of retention of phl...Objective：To explore the effect of Tanreqing Injection（痰热清注射液,TRQI） on the treatment of acute exacerbation of chronic obstructive pulmonary disease（AECOPD） with Chinese medicine syndrome of retention of phlegm and heat in Fei（痰热阻肺证,RPHF）.Methods：In a prospective randomized controlled clinical trial,90 patients with AECOPD of RPHF syndrome were randomly assigned to 3 groups,TRQI and controls A and B,each with 30 cases.The TRQI group was administered with the intravenous injections of 20 mL TRQI once a day and conventional Western medicine treatment.Control group A was administered with the intravenous injection of 15 mg ambroxol hydrochloride twice a day and conventional Western medicine treatment,and control group B was administered with conventional Western medicine treatment only.The treatments were administered for 10 days.Chinese medical symptoms and signs were scored,and plasma concentrations of interleukin（IL）-8 and neutrophil elastase（NE） were recorded.Results：（1） The Chinese medical symptoms （cough,sputum amount,expectoration,dyspnea and fever） and signs（tongue and pulse） improved significantly in the TRQI group（P〈0.05 or P〈0.01）,and improvements in cough,sputum amount and expectoration were better in the TRQI group than control group B（P〈0.05）;there was no significant difference between the TRQI group and control group A（P〉0.05）.The sign of tongue was also improved significantly in the TRQI group （P〈0.05）.（2） The overall effects in the TRQI group and control group A were significantly better than in control group B（P〈0.05）,with no significant differences between the TRQI group and control group A（P〉0.05）.There was no significant difference in the total effective rate among the three groups（P〉0.05）.（3） After treatment, the plasma concentrations of IL-8 and NE decreased in the TRQI group and control group A（P〈0.05）,and the concentration of IL-8 in control group B decreased（P〈0.05）.The展开更多
Objective:To objectively evaluate the clinical effect of traditional Chinese medicine in treating children s respiratory syncytial viral pneumonia(RSVP) of phlegm-heat blocking Fei(肺) syndrome(PHBFS). Methods:A singl...Objective:To objectively evaluate the clinical effect of traditional Chinese medicine in treating children s respiratory syncytial viral pneumonia(RSVP) of phlegm-heat blocking Fei(肺) syndrome(PHBFS). Methods:A single-blinded multi-center,blocked,randomized and parallel-controlled method was adopted.The clinical study was carried out on 206 children with RSVP-PHBFS who were assigned to two groups,108 in the test group treated through intravenous dripping of Qingkailing Injection(清开灵注射液) in combination of or...展开更多
Background: Scientific procedures for addressing noseband fit and tightness, eliminating the risk of excessive and painful tightening, as well as quantitative measurements of pressures under the noseband while riding ...Background: Scientific procedures for addressing noseband fit and tightness, eliminating the risk of excessive and painful tightening, as well as quantitative measurements of pressures under the noseband while riding are either scarce or lacking. Purpose/Aim: To assess simple means of measuring pressure under different nosebands with a view to their adoption as scientific methodology. Method: Horses (n = 7) were fitted with five different bridles (A-E). Pressure distribution and intensity were measured using colour sensitive film (Fujifilm LLLW), assessing the level of pressure and distribution across the surface of the nosebands, as assessed and ranked by independent assessors. A CURO system was also used to measure pressure in real-time under nosebands whilst riding. Results: The colour-sensitive film for D & B were ranked 1st and 2nd, respectively. Regularity of pressure overall showed a statistical difference between nosebands (A & B significantly more unregular than the others). Pressure measurements revealed significantly different means (all P Conclusions: Pressures under nosebands can reach levels that appear capable of inflicting tissue damage, hence bridles and nosebands should be assessed using scientific methodology and not based on arbitrary and subjective criteria, as is currently the case.展开更多
Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain unclear.The objec...Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain unclear.The objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 treatment.Materials and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking studies.Results:In total,288 effective QDQF1 ingredients were identified.We identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related targets.Six key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network analyses.GO functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling pathways.Nine central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment analysis.Furthermore,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to remdesivir.Conclusions:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.展开更多
General Yue Fei has long been considered a symbol of loyalty and resistance in Chinese history. His legend has been circulating in various forms since the twelfth century. In the context of the emerging women-authored...General Yue Fei has long been considered a symbol of loyalty and resistance in Chinese history. His legend has been circulating in various forms since the twelfth century. In the context of the emerging women-authored tanci narratives and the political disorder of late 19th century China, this article examines how the gentry woman author Zhou Yingfang （1829-95） enriches the narratives of Yue Fei by inserting a number of domestic themes into her tanci adaptation. She redefines the virtues of both genders and expects transformed family dynamics. In considering scholarly interpretations of the tanci in the modem period, this article also argues that the May Fourth scholars tended to neglect and/or suppress Zhou Yingfang＇s gendered consciousness in her alternative imagination of history.展开更多
This article studies various means by which female characters determine their own marriages in the tanci 彈詞 , Feng shuang fei 風雙飛, authored by a female writer, Cheng Huiying 程蕙英. It centers on case studies of ...This article studies various means by which female characters determine their own marriages in the tanci 彈詞 , Feng shuang fei 風雙飛, authored by a female writer, Cheng Huiying 程蕙英. It centers on case studies of the concubines in the Guo and Zhang families. Zhen Daya, who marries Guo Lingyun, builds an individual identity as a chaste, talented and determined ＂career woman＂ through her pursuit of a self-determined marriage Zhen Xiaoya, Zhang Yishao＇s concubine, establishes her subjectivity by following the cult of chastity. By creating such a character, the female writer mocks the conventions of scholar-beauty romances and rethinks the contemporary tradition of romance and marriage. The last case is the author＇s strikingly sympathetic treatment of an unchaste girl, Bao Xiang＇er. Although the multiple layers of voices all agree that Xiang＇er is totally inappropriate and immoral according to traditional Confucian values, she, instead of being punished, still ends up being incorporated into Yishao＇s family and is granted a son. These cases allow us to reevaluate Cheng Huiying, a female writer, and her views of women＇s autonomy in determining their own marriages. They anticipate, either through fantasy or some level of reality, the concept of ＂free love＂ （ziyou lian ＇ai） so central to the May Fourth conceptions of modem women.展开更多
Objective： By applying moxibustion to the eight confluent points in different periods of time, to observe the changes in thermal pain threshold latency of acupoints based on Fei Teng Ba Fa. Methods： A total of 468 h...Objective： By applying moxibustion to the eight confluent points in different periods of time, to observe the changes in thermal pain threshold latency of acupoints based on Fei Teng Ba Fa. Methods： A total of 468 healthy college student volunteers received moxibustion at the eight confluent points in three different periods of time, i.e. Chen （7：00-9：00）, Wu （11：00-13：00） and Xu （19：00-21：00）. The thermal pain threshold latency was adopted to measure the changes in pain threshold of the eight confluent points under different conditions （different periods of time, different genders, different acupoints and different states of the acupoints） based on Fei Teng Ba Fa. Results： Finally, thirty subjects dropped out and 438 subjects were included. The comparison of thermal pain threshold latencies of the eight confluent points in the same opening or closing state based on Fei Teng Ba Fa： latencies of the closing points and adjunct points were significantly different in different periods of time （P〈0.05）, the latencies of the males were significantly longer than those of the females （P〈0.05）; there was no significant difference in the latency between the left and right sides （P〉0.05）; in the female group, there was a significant difference in the latency between the lower-limb points and the upper-limb points （P〈0.05）. The comparison of thermal point threshold latencies of the eight confluent points in different opening or closing state： in the period of Wu （11：00-13：00）, the latencies of the opening points were significantly longer than those of the closing points and adjunct points （P〈0.05）; for men, their opening and closing points had significantly longer thermal pain threshold latencies than their adjunct points （P〈0.05）; despite the gender, the latencies of the upper limb opening and closing points were significantly longer than the latency of the adjunct points （P〈0.05）; in the female group, the latencies of the lower-limb ope展开更多
According to Yue Fei＇s biography, when the legendary general was slandered and interrogated for treason, he tore the shirt off his body, exposing four characters tattooed on his back： ＂Exhaust one＇s loyalty in ser...According to Yue Fei＇s biography, when the legendary general was slandered and interrogated for treason, he tore the shirt off his body, exposing four characters tattooed on his back： ＂Exhaust one＇s loyalty in service of the state.＂ This study looks at two components of the Yue Fei story--patriotic tattoos, and tattooed generals--and examines their meaning in the broader stretch of Song dynasty history. Yue Eei was not the Song dynasty＇s only tattooed general who came to a tragic end. The Northern Song＇s Di Qing was a tattooed soldier whose military merit allowed him to rise to the highest levels of power in the empire. Di Qing＇s story makes it clear that tattooed generals were objects of suspicion and ridicule at court due to their military tattoos, a trait that linked them to the criminals and lower class men that manned the Song armies. Though military tattoos sometimes had a loyalist ring to them, they were carried out on a mass scale, and were a characteristic of coercion rather than fervent loyalism. This study shows that underneath the nationalist historical narrative of the Song dynasty, of which Yue Eel is a famous example, there lies a different story of social conflict within the Song state. Rather than a story of Chinese fighting non-Chinese and of traitorous and cowardly officials struggling with loyal patriots, this study offers a narrative of a social conflict between high-born clear-skinned officials and low-born tattooed military men.展开更多
Qing Fei Xiao Yan Wan had been incorporated into the existing “Chinese Pharmacopoeia”, protected by patents. The manufacturing process of it was scientific and its compatibility was reasonable. It was also shown by ...Qing Fei Xiao Yan Wan had been incorporated into the existing “Chinese Pharmacopoeia”, protected by patents. The manufacturing process of it was scientific and its compatibility was reasonable. It was also shown by clinical trials that the efficacy is exact. Clinical trials and experiment studies had confirmed the efficacy and some mechanism for the treatment of respiratory diseases, which were summaried in this paper. Combined with the experimental results (published in another paper), the other prospect application was further discussed.展开更多
基金Supported by Scientific and Technolohical Project of Sichuan Science and Technology Agency(No.2006Z08-009).
文摘Objective：To explore the effect of Tanreqing Injection（痰热清注射液,TRQI） on the treatment of acute exacerbation of chronic obstructive pulmonary disease（AECOPD） with Chinese medicine syndrome of retention of phlegm and heat in Fei（痰热阻肺证,RPHF）.Methods：In a prospective randomized controlled clinical trial,90 patients with AECOPD of RPHF syndrome were randomly assigned to 3 groups,TRQI and controls A and B,each with 30 cases.The TRQI group was administered with the intravenous injections of 20 mL TRQI once a day and conventional Western medicine treatment.Control group A was administered with the intravenous injection of 15 mg ambroxol hydrochloride twice a day and conventional Western medicine treatment,and control group B was administered with conventional Western medicine treatment only.The treatments were administered for 10 days.Chinese medical symptoms and signs were scored,and plasma concentrations of interleukin（IL）-8 and neutrophil elastase（NE） were recorded.Results：（1） The Chinese medical symptoms （cough,sputum amount,expectoration,dyspnea and fever） and signs（tongue and pulse） improved significantly in the TRQI group（P〈0.05 or P〈0.01）,and improvements in cough,sputum amount and expectoration were better in the TRQI group than control group B（P〈0.05）;there was no significant difference between the TRQI group and control group A（P〉0.05）.The sign of tongue was also improved significantly in the TRQI group （P〈0.05）.（2） The overall effects in the TRQI group and control group A were significantly better than in control group B（P〈0.05）,with no significant differences between the TRQI group and control group A（P〉0.05）.There was no significant difference in the total effective rate among the three groups（P〉0.05）.（3） After treatment, the plasma concentrations of IL-8 and NE decreased in the TRQI group and control group A（P〈0.05）,and the concentration of IL-8 in control group B decreased（P〈0.05）.The
基金Supported by the National Key Technologies Research and Development Program of China during the 10th Five-Year PlanPeriod(No.2004BA716B03)
文摘Objective:To objectively evaluate the clinical effect of traditional Chinese medicine in treating children s respiratory syncytial viral pneumonia(RSVP) of phlegm-heat blocking Fei(肺) syndrome(PHBFS). Methods:A single-blinded multi-center,blocked,randomized and parallel-controlled method was adopted.The clinical study was carried out on 206 children with RSVP-PHBFS who were assigned to two groups,108 in the test group treated through intravenous dripping of Qingkailing Injection(清开灵注射液) in combination of or...
文摘Background: Scientific procedures for addressing noseband fit and tightness, eliminating the risk of excessive and painful tightening, as well as quantitative measurements of pressures under the noseband while riding are either scarce or lacking. Purpose/Aim: To assess simple means of measuring pressure under different nosebands with a view to their adoption as scientific methodology. Method: Horses (n = 7) were fitted with five different bridles (A-E). Pressure distribution and intensity were measured using colour sensitive film (Fujifilm LLLW), assessing the level of pressure and distribution across the surface of the nosebands, as assessed and ranked by independent assessors. A CURO system was also used to measure pressure in real-time under nosebands whilst riding. Results: The colour-sensitive film for D & B were ranked 1st and 2nd, respectively. Regularity of pressure overall showed a statistical difference between nosebands (A & B significantly more unregular than the others). Pressure measurements revealed significantly different means (all P Conclusions: Pressures under nosebands can reach levels that appear capable of inflicting tissue damage, hence bridles and nosebands should be assessed using scientific methodology and not based on arbitrary and subjective criteria, as is currently the case.
基金funded by the National Natural Science Foundation of China(81973543)the Shanghai Sailing Program(No.22YF1449800),China。
文摘Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain unclear.The objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 treatment.Materials and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking studies.Results:In total,288 effective QDQF1 ingredients were identified.We identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related targets.Six key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network analyses.GO functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling pathways.Nine central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment analysis.Furthermore,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to remdesivir.Conclusions:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.
文摘General Yue Fei has long been considered a symbol of loyalty and resistance in Chinese history. His legend has been circulating in various forms since the twelfth century. In the context of the emerging women-authored tanci narratives and the political disorder of late 19th century China, this article examines how the gentry woman author Zhou Yingfang （1829-95） enriches the narratives of Yue Fei by inserting a number of domestic themes into her tanci adaptation. She redefines the virtues of both genders and expects transformed family dynamics. In considering scholarly interpretations of the tanci in the modem period, this article also argues that the May Fourth scholars tended to neglect and/or suppress Zhou Yingfang＇s gendered consciousness in her alternative imagination of history.
文摘This article studies various means by which female characters determine their own marriages in the tanci 彈詞 , Feng shuang fei 風雙飛, authored by a female writer, Cheng Huiying 程蕙英. It centers on case studies of the concubines in the Guo and Zhang families. Zhen Daya, who marries Guo Lingyun, builds an individual identity as a chaste, talented and determined ＂career woman＂ through her pursuit of a self-determined marriage Zhen Xiaoya, Zhang Yishao＇s concubine, establishes her subjectivity by following the cult of chastity. By creating such a character, the female writer mocks the conventions of scholar-beauty romances and rethinks the contemporary tradition of romance and marriage. The last case is the author＇s strikingly sympathetic treatment of an unchaste girl, Bao Xiang＇er. Although the multiple layers of voices all agree that Xiang＇er is totally inappropriate and immoral according to traditional Confucian values, she, instead of being punished, still ends up being incorporated into Yishao＇s family and is granted a son. These cases allow us to reevaluate Cheng Huiying, a female writer, and her views of women＇s autonomy in determining their own marriages. They anticipate, either through fantasy or some level of reality, the concept of ＂free love＂ （ziyou lian ＇ai） so central to the May Fourth conceptions of modem women.
文摘Objective： By applying moxibustion to the eight confluent points in different periods of time, to observe the changes in thermal pain threshold latency of acupoints based on Fei Teng Ba Fa. Methods： A total of 468 healthy college student volunteers received moxibustion at the eight confluent points in three different periods of time, i.e. Chen （7：00-9：00）, Wu （11：00-13：00） and Xu （19：00-21：00）. The thermal pain threshold latency was adopted to measure the changes in pain threshold of the eight confluent points under different conditions （different periods of time, different genders, different acupoints and different states of the acupoints） based on Fei Teng Ba Fa. Results： Finally, thirty subjects dropped out and 438 subjects were included. The comparison of thermal pain threshold latencies of the eight confluent points in the same opening or closing state based on Fei Teng Ba Fa： latencies of the closing points and adjunct points were significantly different in different periods of time （P〈0.05）, the latencies of the males were significantly longer than those of the females （P〈0.05）; there was no significant difference in the latency between the left and right sides （P〉0.05）; in the female group, there was a significant difference in the latency between the lower-limb points and the upper-limb points （P〈0.05）. The comparison of thermal point threshold latencies of the eight confluent points in different opening or closing state： in the period of Wu （11：00-13：00）, the latencies of the opening points were significantly longer than those of the closing points and adjunct points （P〈0.05）; for men, their opening and closing points had significantly longer thermal pain threshold latencies than their adjunct points （P〈0.05）; despite the gender, the latencies of the upper limb opening and closing points were significantly longer than the latency of the adjunct points （P〈0.05）; in the female group, the latencies of the lower-limb ope
文摘According to Yue Fei＇s biography, when the legendary general was slandered and interrogated for treason, he tore the shirt off his body, exposing four characters tattooed on his back： ＂Exhaust one＇s loyalty in service of the state.＂ This study looks at two components of the Yue Fei story--patriotic tattoos, and tattooed generals--and examines their meaning in the broader stretch of Song dynasty history. Yue Eei was not the Song dynasty＇s only tattooed general who came to a tragic end. The Northern Song＇s Di Qing was a tattooed soldier whose military merit allowed him to rise to the highest levels of power in the empire. Di Qing＇s story makes it clear that tattooed generals were objects of suspicion and ridicule at court due to their military tattoos, a trait that linked them to the criminals and lower class men that manned the Song armies. Though military tattoos sometimes had a loyalist ring to them, they were carried out on a mass scale, and were a characteristic of coercion rather than fervent loyalism. This study shows that underneath the nationalist historical narrative of the Song dynasty, of which Yue Eel is a famous example, there lies a different story of social conflict within the Song state. Rather than a story of Chinese fighting non-Chinese and of traitorous and cowardly officials struggling with loyal patriots, this study offers a narrative of a social conflict between high-born clear-skinned officials and low-born tattooed military men.
文摘Qing Fei Xiao Yan Wan had been incorporated into the existing “Chinese Pharmacopoeia”, protected by patents. The manufacturing process of it was scientific and its compatibility was reasonable. It was also shown by clinical trials that the efficacy is exact. Clinical trials and experiment studies had confirmed the efficacy and some mechanism for the treatment of respiratory diseases, which were summaried in this paper. Combined with the experimental results (published in another paper), the other prospect application was further discussed.
